2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-162274
    Oxazepine 98%
    Oxazepine (compound 4a) has antimicrobial viability via binding OMPA/ exo-1,3-beta-glucanase proteins. Oxazepine is a hedgehog signaling inhibitor with antitumor viability.
    Oxazepine
  • HY-162279
    Insecticidal agent 8 98%
    Insecticidal agent 8 ((S)-4a-14) is an insecticidal agent that has significant selective biological against Aphis craccivora Koch and Plutella xylostella.
    Insecticidal agent 8
  • HY-162290
    Z2206320703 98%
    Z2206320703 is a potential lead candidate compound against IspC.
    Z2206320703
  • HY-162295
    SARS-CoV-2-IN-83 98%
    SARS-CoV-2-IN-83 (compound C6E) has excellent activity against SARS CoV-2 spike protein.
    SARS-CoV-2-IN-83
  • HY-162296
    Antibacterial agent 188 88312-54-3 98%
    Antibacterial agent 188 (compound 2d) is an antibacterial agent that inhibits dermatophyte activity.
    Antibacterial agent 188
  • HY-162313
    NIP-22c 2309384-85-6 98%
    NIP-22c is a novel coronavirus 3CLpro inhibitor. The EC50 for Verona, Calu3, Caco2 and HBTEC-ALI were 4.6, 1.1, 0.1 and 0.6 μM, respectively. NIP-22c has antiviral activity.
    NIP-22c
  • HY-162317
    AMPK-IN-5 98%
    AMPK-IN-5 (compound 7m) is a Osthole (HY-N0054) derivative, and blocks MAPK signal transduction by inhibiting the phosphorylation of JNK and p38, thereby inhibiting the release of inflammatory cytokines. AMPK-IN-5 reduce DSS-induced ulcerative colitis and LPS (HY-D1056)-induced acute lung injury.
    AMPK-IN-5
  • HY-162327
    PROTAC PAPD5 degrader 1 98%
    PROTAC PAPD5 degrader 1 (compound 12b) inhibits both hepatitis A (HAV) and hepatitis B virus (HBV) in vitro and in vivo, with IC50 and CC50 of 10.59 μM and ＞ 50 μM, respectively in Huh7 cells.
    PROTAC PAPD5 degrader 1
  • HY-162328
    Antibacterial agent 194 2157356-88-0 98%
    Antibacterial agent 194 (Compound 19) is an antibacterial agent. Antibacterial agent 194 has potent anti-Mycobacterium tuberculosis (anti-Mtb) activity (MIC = 1 μg/mL).
    Antibacterial agent 194
  • HY-162329
    Antibacterial agent 195 98%
    Antibacterial agent 195 (compound A20), a Matrine (HY-N0164) derivative, is a potent antibiotic. Antibacterial agent 195 shows antibacterial activity against Gram-positive bacterium (MICS.aureus=0.021 mg/mL; MICP.acnes=0.030 mg/mL), Gram-negative bacterium (MICE.coli=0.092 mg/mL; MICC.albicans=0.379 mg/mL) and Fungus (MIC=2.806 mg/mL).
    Antibacterial agent 195
  • HY-162346
    KN-17 98%
    KN-17 is a modified based on the structure of cecropin B (HY-P0092), can effectively interfere with bacterial growth and induce the migration of human bone marrow stromal cells (hBMSCs). KN-17 can significantly stimulate angiogenesis in vitro and in vivo.
    KN-17
  • HY-162358
    DHFR-IN-17 98%
    DHFR-IN-17 (compound j9) is an oral active SaDHFR inhibitor with the IC50 of 0.97 nM. DHFR-IN-17 shows antibacterial activity against S. aureus with the minimum inhibitory concentration of 0.031 μg/mL.
    DHFR-IN-17
  • HY-162370
    CYP51-IN-16 98%
    CYP51-IN-16 (compound C6) is a phenylpyrimidine CYP51 inhibitor, and shows antifungal activity in in vitro. CYP51-IN-16 inhibits tumor cell growth.
    CYP51-IN-16
  • HY-162371
    NRPSs-IN-1 98%
    NRPSs-IN-1 (Compound 7) is a cell-penetrating inhibitor of non-ribosomal peptide synthetase (NRPSs). NRPSs-IN-1 K inhibits gramicidin S synthetase A (GrsA) with a Kd value of 16.6 nM.
    NRPSs-IN-1
  • HY-162376
    T3SS-IN-4 2316760-41-3 98%
    T3SS-IN-4 (Compound Z-8) is a T3SS inhibitor that can inhibit the expression of Xanthomonas oryzae pv oryzae (Xoo) T3SS-related genes without affecting bacterial growth. T3SS-IN-4 can effectively reduce the hypersensitive response (HR) induced by Xoo in tobacco and lower the pathogenicity of Xoo in rice.
    T3SS-IN-4
  • HY-162400
    TMV-IN-8 3023856-56-3 98%
    TMV-IN-8 (compound 7 d) is an anti tobacco mosaic virus (TMV) agent with an antiviral EC50 of 157.6 μg/mL.TMV-IN-8 blocks the assembly of TMV by binding with coat protein (Kd = 0.7 μM) and suppressed TMV coat protein gene expression and biosynthesis process.
    TMV-IN-8
  • HY-162403
    Antiviral agent 53 98%
    Antiviral agent 53 (Compound (S)-4v) is an antiviral agent that can inhibit the activity of Potato virus Y (PVY) and exhibit excellent curative and protective effects against PVY with EC50 values of 328.6 and 256.1 μg/mL, respectively. Antiviral agent 53 can be used in the research and development of novel pesticides.
    Antiviral agent 53
  • HY-162414
    SARS-CoV-2-IN-84 214221-82-6 98%
    SARS-CoV-2-IN-84 (compound 20) is aSARS-CoV-2 inhibitor that targets the 3CL protease (3CL Pro) of SARS-CoV-2 (IC50: 369.5 nM ).
    SARS-CoV-2-IN-84
  • HY-162418
    Antibacterial agent 203 3034304-89-4 98%
    Antibacterial agent 203 (Compound 5h) has antibacterial and antifungal activity. Antibacterial agent 203 has potent antifungal activity against C. albicans, with a MIC of 3.90 μg/mL. Antibacterial agent 203 has antimicrobial activity on healthy mouse fibroblast cells (L929), with an IC50 of 75.96 μM.
    Antibacterial agent 203
  • HY-162429
    Antibacterial agent 205 98%
    Antibacterial agent 205 (Compound 10d) is a indolylacryloyl-derived oxacins, which exhibits broad antibacterial spectrum with MIC of 0.25-0.5 μg/mL. Antibacterial agent 205 reduces the exopolysaccharide, eliminates the biofilm, and thus attenuates the drug resistance. Antibacterial agent 205 exhibits antibacterial activity through destory of membrane integrity, accumulation of reactive oxygen species ROS, and inhibition of DNA replication.
    Antibacterial agent 205
Cat. No. Product Name / Synonyms Application Reactivity