Oxazepine
Oxazepine is an antifungal agent belonging to the class of seven-membered heterocyclic azepine derivatives. Oxazepine exerts inhibitory effects on Candida species as well as Gram-positive and Gram-negative bacteria, and exerts anti-inflammatory effects by stabilizing human erythrocyte membranes. Oxazepine can be used in research on infectious diseases.
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- Fòrmula: C37H27N3O2
- Peso molecular:545.63
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
33.04 μM
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Antiproliferative activity against human Caco-2 colorectal cancer cells assessed as viability reduction by MTT assay after 48 hrs incubation.
Antiproliferative activity against human Caco-2 colorectal cancer cells assessed as viability reduction by MTT assay after 48 hrs incubation.
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36493622 |
| PANC-1 | IC50 |
50.87 μM
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Antiproliferative activity against human PANC-1 pancreatic cancer cells assessed as viability reduction by MTT assay after 48 hrs incubation.
Antiproliferative activity against human PANC-1 pancreatic cancer cells assessed as viability reduction by MTT assay after 48 hrs incubation.
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36493622 |
| MCF7 | IC50 |
55.69 μM
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Antiproliferative activity against human MCF-7 breast cancer cells assessed as viability reduction by MTT assay after 48 hrs incubation.
Antiproliferative activity against human MCF-7 breast cancer cells assessed as viability reduction by MTT assay after 48 hrs incubation.
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36493622 |
| MDA-MB-231 | IC50 |
46.83 μM
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Antiproliferative activity against human MDA-MB-231 breast cancer cells assessed as viability reduction by MTT assay after 48 hrs incubation.
Antiproliferative activity against human MDA-MB-231 breast cancer cells assessed as viability reduction by MTT assay after 48 hrs incubation.
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36493622 |
| A549 | IC50 |
40.50 μM
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Antiproliferative activity against human A549 lung cancer cells assessed as viability reduction by MTT assay after 48 hrs incubation.
Antiproliferative activity against human A549 lung cancer cells assessed as viability reduction by MTT assay after 48 hrs incubation.
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36493622 |
| WISH | IC50 |
126 μM
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Cytotoxicity against human WISH normal amniotic cells assessed by MTT assay after 48 hrs incubation.
Cytotoxicity against human WISH normal amniotic cells assessed by MTT assay after 48 hrs incubation.
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36493622 |
In Vitro
Oxazepine (compound 7a) (0-200 μM; 48 h) inhibits the proliferation of Caco-2 colorectal cancer cells with an IC50 of 33.04 μM, while showing lower cytotoxicity against WISH normal cells with an IC50 of 126 μM[4].
Oxazepine upregulates TSC2, Bax, and p53 and downregulates Bcl-2 in Caco-2 colorectal cancer cells[4].
Oxazepine (48 h) inhibits the PI3K/Akt/mTOR signaling pathway in Caco-2 colorectal cancer cells by reducing the phosphorylation of PI3K, Akt, and mTOR[4].
Oxazepine (IC12.5-IC50; 48 h) induces dose-dependent apoptotic morphological changes in Caco-2 colorectal cancer cells[4].
Oxazepine (IC12.5-IC50; 48 h) arrests Caco-2 colorectal cancer cells in the sub-G0/G1 phase in a dose-dependent manner, reaching 34.3% at the IC50[4].
Oxazepine (48 h) induces oxidative stress in Caco-2 colorectal cancer cells by increasing MDA and decreasing GSH[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caco-2 colorectal cancer cells
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Concentration:IC12.5, IC25, IC50
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Incubation Time:48 h
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Result:Caco-2 cells showed visible morphological signs of apoptosis in a dose-dependent manner, including cytoplasmic condensation and cell detachment.
Control cells appeared normal, spindle-shaped, and confluent.
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Cell Line:Caco-2 colorectal cancer cells
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Concentration:IC12.5, IC25, IC50
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Incubation Time:48 h
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Result:Induced dose-dependent accumulation of Caco-2 cells in the sub-G0/G1 phase: 10.8%, 19.9%, and 34.3% at IC12.5, IC25, and IC50, respectively, compared with 2.1% in control cells.
Chemical Information
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Peso molecular 545.63
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Fòrmula C37H27N3O2
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SMILES
O=C1N(C2=CC=C(C3=NC4=CC=CC=C4OC(/C=C/C5=CC=CC=C5)C3)C=C2)C(C6=CC=CC=C6)=NC7=C1C=CC=C7
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Che J, et al. Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment. Journal of medicinal chemistry. 2023 Oct 12;66(19):13530-13555. [Content Brief]
[2]. Anaissi-Afonso L, et al. Fused oxazepine-naphthoquinones as novel cytotoxic agents with diverse modes of action in yeast. Heliyon. 2024 Dec 30;10(24):e41105. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oxazepine Related Classifications
HY-162274 Related Classifications
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