Infection

Related Products

Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Infection Related Products (17952)
Antibodies (22)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-172222

Antifungal agent 127	3070364-24-5	98%
Antifungal agent 127 (Compound 6c) is an antifungal agent. Antifungal agent 127 exhibits strong inhibitory activity against Botrytis cinerea, Rhizoctonia solani, and other fungi.

HY-172243

Xeruborbactam isoboxil	2708983-65-5	98%
Xeruborbactam isoboxil is a beta-lactamase inhibitor.

HY-172263

KU13	3066104-44-4	98%
KU13 is an inhibitor of nontuberculous mycobacteria (NTM). The minimum inhibitory concentrations (MIC) of KU13 against Mycobacterium and E. coli are 0.032-8 μg/mL and 2 μg/mL, respectively. KU13 can be used for research in the field of anti-infection .

HY-172264

XT17		98%
XT17 is an anthrone compound with broad-spectrum antibacterial activity. It exerts its antibacterial effect by disrupting the cell wall and inhibiting DNA synthesis. XT17 exhibits weak hemolytic activity, low cytotoxicity against mammalian cell lines, and a low frequency of drug resistance. Meanwhile, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies have confirmed that XT17 can form a stable complex with bacterial gyrase. XT17 can be used in the research of the anti - infection field.

HY-172279

DSPE-PEG1000-TAT		98%
DSPE-PEG1000-TAT is a PEG compound which composed of DSPE and a cell-penetrating peptide (TAT) (HY-P0281). DSPE-PEG1000-TAT can be used for drug delivery.

HY-172298

(R,S,S,S)-Orlistat	104872-28-8	98%
(R,S,S,S)-Orlistat is a stereogenic derivative of orlistat (tetrahydrolipstatin; THL) (HY-B0218). (R,S,S,S)-Orlistat inhibits three Mycobacterium tuberculosis lipid esterases, Ag85C (KI: 16.43 μM), Rv3802 (EC50: 16.2 nM), and Pks13-TE.

HY-172349

JNJ-2901	2059985-55-4	98%
JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. JNJ-2901 reduces bacterial load in the acute/chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 can be used in tuberculosis (TB) research.

HY-172350

WEHI-P8		98%
WEHI-P8 is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC₅₀ of 12 nM and a K_d of 9.0 nM. WEHI-P8 reduces viral load, body weight loss, pulmonary inflammation, immune cell infiltration and pro-inflammatory mediator levels in SARS-CoV-2-infected mice. WEHI-P8 prevents pulmonary hemorrhage, immune cell infiltration, fibrotic remodeling and neuroinflammation, and improves cognitive function in a mouse model of post-acute sequelae of SARS-CoV-2 infection (PASC). WEHI-P8 is applicable for the research of COVID-19 and PASC.

HY-172362

SDH-IN-22		98%
SDH-IN-22 (Compound SEZC7) is the inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 16.6 μM. SDH-IN-22 exhibits antifungal activity that inhibits Magnaporthe grisea with an EC₅₀ of 0.5 mg/L.

HY-172363

Succinate dehydrogenase-IN-6		98%
Succinate dehydrogenase-IN-6 (Compound E23) is the inhibitor for succinate dehydrogenase that inhibits SDH in Rhizoctonia solani with an IC₅₀ of 11.76 μM. Succinate dehydrogenase-IN-6 disrupts fungal cell membrane, exhibits board-spectrum antifungal activity that inhibits R. solani, V. dahliae, A. solani and C. gloeosporioides with EC₅₀s of 0.41, 0.27, 1.15, 0.27 μg/mL, respectively. Succinate dehydrogenase-IN-6 exhibits no significant toxicity in rice and zebrafish (LC₅₀ > 12.5 μg/mL).

HY-172428

Encofosbuvir	2232134-77-7	98%
Encofosbuvir is the inhibitor for HCV NS5B polymerase that inhibits GT1b, GT2a and GT3a with EC₅₀ of 102.4, 82.51 and 46.91 nM. Encofosbuvir inhibits HCV replication and can be used for reseearchs of hepatitis C in mammals.

HY-172456

JSF-4898		98%
JSF-4898 is an orally active inhibitor of the MenG enzyme in Mycobacterium tuberculosis. JSF-4898 has MIC of 0.78 μM against Mycobacterium tuberculosis H37Rv. JSF-4898 can enhance the efficacy of Rifampicin (HY-B0272) in a subacute model of Mycobacterium tuberculosis infection in mice.

HY-172523

CDA-IN-3	932889-57-1	98%
CDA-IN-3 (NCDI) is an inhibitor of chitin deacetylase (CDA) with anti-parasitic activity. CDA-IN-3 disrupts the chitin metabolism of nematodes, leading to an increase in the level of ROS in nematodes and causing cell damage. CDA-IN-3 has a significant inhibitory effect on all developmental stages of Caenorhabditis elegans. CDA-IN-3 can be used in the research of the anti-infection field .

HY-172553

AS-0017445		98%
AS-0017445 is an inhibitor targeting the main protease of both the current coronavirus and the virus that caused the Middle East Respiratory Syndrome (MERS) outbreak. AS-0017445 inhibits the viral protein processing in host cells and thus prevents viral replication.

HY-172606

NagZ-IN-1		98%
NagZ-IN-1 (Compound 11h) is an inhibitor of β-N-acetylglucosaminidase with a K_i of 3.3 μM. NagZ-IN-1 can be used in the field of antibacterial research, especially for studies related to Pseudomonas aeruginosa infections.

HY-172607

Carbonic anhydrase inhibitor 30		98%
Carbonic anhydrase inhibitor 30 (compound 17) is an inhibitor of carbonic anhydrase with K_i values of 2.13 μM and 0.161 nM for hCA I and hCA II, respectively^{[1]^.}

HY-172661

Kylo-0603	2661053-09-2	98%
KYLO-0603 is an orally active, selective THR-β agonist (EC₅₀ : 31.07 nM). KYLO-0603 has significant activity in lowering serum cholesterol and low-density lipoprotein cholesterol. KYLO-0603 upregulates the expression of THR-regulated genes (including iodothyronine deiodinase 1 (Dio1), malic enzyme 1 (Me1), and thyroid hormone response (Thrsp) gene) and inhibits the expression of inflammatory and fibrotic genes (low-density lipoprotein receptor (LDL-R) gene) by activating THR-β receptors. KYLO-0603 can be used to treat metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis research.

HY-172713

DSPE-PEG1000-MPG		98%
DSPE-PEG1000-MPG is a PEG compound which composed of DSPE and a peptide vector (MPG). MPG is derived from both the nuclear localisation sequence (NLS) of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. MPG could deliver short oligonucleotides into cells efficiently and independently of the endosomal pathway.

HY-172714

DSPE-PEG2000-MPG		98%
DSPE-PEG2000-MPG is a PEG compound which composed of DSPE and a peptide vector (MPG). MPG is derived from both the nuclear localisation sequence (NLS) of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. MPG could deliver short oligonucleotides into cells efficiently and independently of the endosomal pathway.

HY-172715

DSPE-PEG5000-MPG		98%
DSPE-PEG5000-MPG is a PEG compound which composed of DSPE and a peptide vector (MPG). MPG is derived from both the nuclear localisation sequence (NLS) of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. MPG could deliver short oligonucleotides into cells efficiently and independently of the endosomal pathway.

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Infection

Infection

Infection Related Products (17952)

Antibodies (22)

Infection Related Products (17952):