(R,S,S,S)-Orlistat
(R,S,S,S)-Orlistat is a stereogenic derivative of orlistat (tetrahydrolipstatin; THL) (HY-B0218). (R,S,S,S)-Orlistat inhibits three Mycobacterium tuberculosis lipid esterases, Ag85C (KI: 16.43 μM), Rv3802 (EC50: 16.2 nM), and Pks13-TE.
For research use only. We do not sell to patients.
- CAS No.: 104872-28-8
- Formula: C29H53NO5
- Molecular Weight:495.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | IC50 |
5 μM
Compound: 2
|
Inhibition of human recombinant DAGL-alpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey COS7 cell membrane by scintillation counting
Inhibition of human recombinant DAGL-alpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey COS7 cell membrane by scintillation counting
|
[PMID: 18831576] |
| MCF7 | IC50 |
>1 x 105 nM
Compound: 2; 2'-epi-THL
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 29541373] |
| MCF7 | IC50 |
>100 μM
Compound: 2; 2'-epi-THL
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 29541373] |
| MDA-MB-231 | IC50 |
>1 x 105 nM
Compound: 2; 2'-epi-THL
|
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 29541373] |
| MDA-MB-231 | IC50 |
>100 μM
Compound: 2; 2'-epi-THL
|
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 29541373] |
| NCI-H460 | IC50 |
>1 x 105 nM
Compound: 2; 2'-epi-THL
|
Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 29541373] |
| NCI-H460 | IC50 |
>100 μM
Compound: 2; 2'-epi-THL
|
Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 29541373] |
Chemical Information
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CAS No. 104872-28-8
-
Molecular Weight 495.73
-
Formula C29H53NO5
-
SMILES
CC(C)C[C@@H](NC=O)C(O[C@@H](CCCCCCCCCCC)C[C@H]1[C@@H](C(O1)=O)CCCCCC)=O
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Synonyms
(R,S,S,S)-Tetrahydrolipstatin; (R,S,S,S)-Ro-18-0647
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)