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Cat. No.: HY-172349

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JNJ-2901

JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. JNJ-2901 reduces bacterial load in the acute/chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 can be used in tuberculosis (TB) research.

For research use only. We do not sell to patients.

CAS No.: 2059985-55-4
Formula: C₂₄H₂₄ClF₃N₄O₃S
Molecular Weight:540.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

JNJ-2901 Chemical Structure

CAS No.: 2059985-55-4

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

JNJ-2901 (0.005 µM-5 mM, 5 d) inhibits the growth of M. tuberculosis H37Rv-ΔcydAB in 7H9 medium (MIC₅₀: 2.5 nM)^[1].
JNJ-2901 inhibits oxygen consumption by the wild-type strain (IC₅₀: 89 nM) and the cytochrome bd knockout strain (ΔcydAB) (IC₅₀: 60 nM) of M. smegmatis, but has no significant effect on the cytochrome bc knockout strain (ΔqcrCAB)^[1].
JNJ-2901 inhibits oxygen consumption by M. smegmatis cytochrome bc^Mtb-like (IC₅₀: 17.4 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

JNJ-2901 (10 mg/kg, s.c., 12 d/8 weeks) reduces bacterial load (3.6-log/4.0-log) in 6-8 week old female Balb/cBy mice in the acute/chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Acute/chronic mouse model infected with M. tuberculosis H37Rv-ΔcydAB, 6-8 weeks old female Balb/cBy mice^[1].
Dosage:

10 mg/kg
Administration:

Subcutaneous injection (s.c.), 12 d for acute infection and 8 weeks for chronic infection
Result:

Reduced bacterial load in an acute infection model in mice (3.6-log) and in a chronic infection model (4.0-log).

Chemical Information

CAS No. 2059985-55-4
Molecular Weight 540.99
Formula C₂₄H₂₄ClF₃N₄O₃S
SMILES

CCC1=C(N2C=C(C=CC2=N1)Cl)C(NCC3=CC=C(C=C3)C4CC5(CN(C5)S(=O)(C(F)(F)F)=O)C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Verma AK, et al. Structural and mechanistic study of a novel inhibitor analogue of M. tuberculosis cytochrome bc1:aa3. NPJ Drug Discov. 2025;2(1):6. doi: 10.1038/s44386-025-00008-3. Epub 2025 Apr 2. PMID: 40191462; PMCID: PMC11964921. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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