2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-175468
    RNA polymerase-IN-3 98%
    RNA polymerase-IN-3 (Compound 28) is a bacterial RNA polymerase (RNAP) inhibitor with antibacterial activity. RNA polymerase-IN-3 inhibits RNA synthesis by competitively blocking the binding of UTP to RNAP (IC50= 0.28 μM). RNA polymerase-IN-3 is promising for research of bacterial infections.
    RNA polymerase-IN-3
  • HY-175475
    MolPort-010-778-422 1223950-00-2
    MolPort-010-778-422 is a high-affinity inhibitor targeting the ACE2 receptor of SARS-CoV-2 virus. MolPort-010-778-422 demonstrates excellent antiviral activity (IC50=8.9 nM). MolPort-010-778-422 is promising for research of SARS-CoV-2.
    MolPort-010-778-422
  • HY-175485
    GaSal-2
    GaSal-2 is a water-soluble anti-pseudomonal agent that targets the extracellular hemocyte HasAp. It binds tightly to HasAp, blocks the transcriptional activation of the bacterial cell surface signaling cascade, and inhibits the growth of Pseudomonas aeruginosa.
    GaSal-2
  • HY-175488
    RPX 7546 98%
    RPX 7546 is a potent inhibitor of metallo-𝛽-lactamases (MBLs) with IC50 values of 1.4 and 48 μM for IMP-1 and IMP-78, respectively. RPX 7546 has antibacterial activity.
    RPX 7546
  • HY-175489
    D-CS319 1770826-25-9
    D-CS319 is a potent inhibitor of metallo-𝛽-lactamases (MBLs) with IC50 values of 2.0 and 3.0 μM for IMP-1 and IMP-78, respectively. D-CS319 has antibacterial activity.
    D-CS319
  • HY-175491
    HIV-1-IN-85 98%
    HIV-1-IN-85 is an orally active HIV-1 inhibitor (IC50 = 72 nM). HIV-1-IN-85 exhibits strong inhibitory activity against wild-type (WT) HIV-1 and NNRTI-resistant single mutant strains (L100I, K103N, Y181C, Y188L, E138K) and moderate efficacy against double mutant strains (F227L+V106A, RES056). HIV-1-IN-85 shows good in vivo safety in ICR mice. HIV-1-IN-85 can be used for the study of HIV-1 infection.
    HIV-1-IN-85
  • HY-175493
    CRT-IN-1
    CRT-IN-1 (compound 6x) is a potent chloroquine resistance transporter (CRT) inhibitor with an IC50 of 0.33 μM. CRT-IN-1 has activity.
    CRT-IN-1
  • HY-175495
    NDM-1-IN-9
    NDM-1-IN-9 (compound M7) is an orally active NDM-1 inhibitor with a Ki value of 3.95 nM.
    NDM-1-IN-9
  • HY-175499
    SARS-CoV-2-IN-118 98%
    SARS-CoV-2-IN-118 (compound A.13) is an inhibitor that targets the SARS-CoV-2 RNA translation initiation element SL1.
    SARS-CoV-2-IN-118
  • HY-175501
    Succinate dehydrogenase-IN-11 98%
    Succinate dehydrogenase-IN-11 (Compound A12) is a succinate dehydrogenase inhibitor with an IC50 value of 3.58 μM. Succinate dehydrogenase-IN-11 exhibits antifungal activity. Succinate dehydrogenase-IN-11 shows activity against fungi such as R. solani, B. cinerea, F. graminearum, and S. sclerotiorum in vitro. Succinate dehydrogenase-IN-11 also exerts a controlling effect on R. solani, P. pachyrhizi, and P. sorghi in vivo. Succinate dehydrogenase-IN-11 can be used in research related to antifungal applications.
    Succinate dehydrogenase-IN-11
  • HY-175503
    LysRs-IN-4 2973324-63-7
    LysRS-IN-4 (Compound 49) is an orally active Mycobacterium tuberculosis LysRS (lysyl-tRNA synthetase) inhibitor. LysRS-IN-4 is promising for research of tuberculosis.
    LysRs-IN-4
  • HY-175506
    RyRs activator 6
    RyRs activator 6 (compound C3) is a ryanodine receptor (RyRs) activator that activates calcium release in insect neurons. RyRs activator 6 has insecticidal activity.
    RyRs activator 6
  • HY-175507
    TRPMPZQ-IN-1 98%
    TRPMPZQ-IN-1 (Compound 52) is a TRPMPZQ inhibitor, with an EC50 of 0.38 μM against TRPMPZQ from Spirometra erinaceieuropaei. TRPMPZQ-IN-1 exhibits antiparasitic activity, showing an EC50 of 4.3 μM against Echinococcus multilocularis. TRPMPZQ-IN-1 can be used in antiparasitic research.
    TRPMPZQ-IN-1
  • HY-175517
    PEX5-PEX14 PPI-IN-3
    PEX5-PEX14 PPI-IN-3 (Compound 7) is an inhibitor of the PEX5-PEX14 protein-protein interaction (PPI) with an EC50 of 95 μM. PEX5-PEX14 PPI-IN-3 has an EC50 of 7.2 μM against Trypanosoma brucei (T. brucei). PEX5-PEX14 PPI-IN-3 exhibits low cytotoxicity towards HepG2 cells and possesses antiparasitic activity.
    PEX5-PEX14 PPI-IN-3
  • HY-175519
    NNRT-IN-11 98%
    NNRT-IN-11 (14l) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor with EC50 values of 6.50 to 52.9 nM against WT and a panel of HIV-1 mutants. NNRT-IN-11 has antiviral activity.
    NNRT-IN-11
  • HY-175534
    SRI-45949 98%
    SRI-45949 is an allosteric modulator of the HIV-DAT-Tat interaction. SRI-45949 has IC50 values of 9.56 μM and 9.34 μM for [3H]DA uptake and [3H]WIN35,428 binding, respectively. SRI-45949 can be used in research related to HIV-associated neurocognitive disorders.
    SRI-45949
  • HY-175535
    SRI-32743 1940118-42-2
    SRI-32743 is an allosteric human dopamine transporter (hDAT) modulator (IC50=9.86 μM). SRI-32743 is promising for research of HIV-Tat-induced neurotoxicity.
    SRI-32743
  • HY-175536
    AAK1-IN-11
    AAK1-IN-11 is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2 nM. AAK1-IN-11 has antiviral activity.
    AAK1-IN-11
  • HY-175539
    DNA gyrase/Topo IV-IN-2 98%
    DNA gyrase/Topo IV-IN-2 (Compound AK19) is an antibacterial agent with IC50 values of 0.783 μM and 7.136 μM against E. coli DNA gyrase and topoisomerase IV, respectively. DNA gyrase/Topo IV-IN-2 exhibits broad-spectrum antibacterial efficacy against both Gram-positive and Gram-negative pathogens. DNA gyrase/Topo IV-IN-2 can inhibit the biofilms of B. subtilis and MRSA, with an MIC of 1.9 μM against both B. subtilis and MRSA. DNA gyrase/Topo IV-IN-2 can be used in research related to anti-drug-resistant bacterial drugs.
    DNA gyrase/Topo IV-IN-2
  • HY-175550
    HIV-1-IN-86 2801703-64-8
    HIV-1-IN-86 (compound 6m) is a HIV-1 inhibitor with an EC50 of 0.77 μM. HIV-1-IN-86 has antiviral activity.
    HIV-1-IN-86
Cat. No. Product Name / Synonyms Application Reactivity