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Cat. No.: HY-175506

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RyRs activator 6

RyRs activator 6 (compound C3) is a ryanodine receptor (RyRs) activator that activates calcium release in insect neurons. RyRs activator 6 has insecticidal activity.

For research use only. We do not sell to patients.

Formula: C₁₇H₁₄N₆O₄
Molecular Weight:366.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

RyRs activator 6 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

RyRs activator 6 (compound C3) is a ryanodine receptor (RyRs) activator that activates calcium release in insect neurons. RyRs activator 6 has insecticidal activity^[1].

All Parasite Isoforms :

All Calcium Channel Isoforms :

Chemical Information

Molecular Weight 366.33
Formula C₁₇H₁₄N₆O₄
SMILES

O=C(OC1=CC(C#N)=CN=C1)/C=C/C(N2C)=NC(N(C)C(N3C)=O)=C2C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Signal Pathway Related

Calcium Spark Assay
Calcium sparks are localized, transient increases in intracellular calcium concentration ([Ca²⁺]i) that occur in cardiac myocytes and represent elementary events underlying excitation-contraction coupling. These events are generated by the coordinated opening of clusters of ryanodine receptors (RyRs) on the sarcoplasmic reticulum membrane, leading to a brief release of Ca²⁺ into the cytosol. The detection and analysis of calcium sparks provide insights into the mechanisms of calcium handling and signaling in cardiac cells. Imaging techniques using fluorescent calcium indicators such as Fluo-3 are employed to visualize these subcellular calcium transients with high spatial and temporal resolution. The protocol is based on established methodologies described in primary literature for both experimental measurement and automated analysis of calcium sparks.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chang Y, et al. Studies on the Design, Synthesis, and Insecticidal Activity Evaluation of New Caffeine-Acrylate Derivatives as Potential Ryanodine Receptor Activators. J Agric Food Chem. 2025 Aug 13;73(32):19921-19934. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Protocols
Purity & Documentation
References

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RyRs activator 6

All Parasite Isoforms

All Calcium Channel Isoforms