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Cat. No.: HY-175517

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PEX5-PEX14 PPI-IN-3

PEX5-PEX14 PPI-IN-3 (Compound 7) is an inhibitor of the PEX5-PEX14 protein-protein interaction (PPI) with an EC₅₀ of 95 μM. PEX5-PEX14 PPI-IN-3 has an EC₅₀ of 7.2 μM against Trypanosoma brucei (T. brucei). PEX5-PEX14 PPI-IN-3 exhibits low cytotoxicity towards HepG2 cells and possesses antiparasitic activity.

For research use only. We do not sell to patients.

Formula: C₂₄H₂₁FN₂O₂
Molecular Weight:388.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PEX5-PEX14 PPI-IN-3 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Parasite Isoforms :

Chemical Information

Molecular Weight 388.43
Formula C₂₄H₂₁FN₂O₂
SMILES

[H]N(C1=CC2=C(N(C(C3=CC=CC=C3C2)=O)CC)C=C1)C(CC4=CC=C(C=C4)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nowacki M, et al. Quantum mechanics-driven structure-activity relationship study of PEX5-PEX14 protein-protein interaction inhibitors based on a dibenzo [b, e] azepin-6 (6H)-one scaffold. European Journal of Medicinal Chemistry, 2025: 117979.

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Topics Protein-Protein Interaction: Therapeutic Target-Beyond Cancer
Protein-protein interactions (PPIs) constitute the molecular framework that organizes signaling networks, gene regulation, metabolism, immunity, and cellular homeostasis.

2026-06-18
Topics A Review of the Mechanisms and Applications of Protein-Protein Interactions (PPIs)
Protein-protein interactions (PPIs) are physical or functional connections formed by two or more proteins through specific interfaces, and they underlie signal transduction, transcriptional regulation, protein degradation, cell-cycle control, DNA repair, immune recognition, and cell death.

2026-06-18

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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