2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-129566R
    Withanolide B (Standard) 56973-41-2
    Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects.
    Withanolide B (Standard)
  • HY-129764A
    (17E)-Prostaglandin F3α 211100-24-2 98%
    (17E)-Prostaglandin F3α (17-trans-PGF3α) is a double bond isomer of Prostaglandin F3α (HY-129764) and a potential metabolite of trans dietary fatty acids. (17E)-Prostaglandin F3α has anti-inflammatory activity.
    (17E)-Prostaglandin F3α
  • HY-129853A
    Doxpicomine 62904-71-6 98%
    Doxpicomine is an analgesic with potent activity, effective in treating severe postoperative pain.
    Doxpicomine
  • HY-129953B
    15(R)-Prostaglandin F2α 37658-84-7 98%
    15(R)-Prostaglandin F2α is the isomer of 9α,11β-Prostaglandin F2α (HY-129953). 9α,11β-Prostaglandin F2α is an endogenous metabolite present in Urine that can be used for the research of Asthma.
    15(R)-Prostaglandin F2α
  • HY-129953S
    9α,11β-Prostaglandin F2α-d4 98%
    9α,11β-Prostaglandin F2α-d4 is a deuterated labeled 9α,11β-Prostaglandin F2α. 9α,11β-Prostaglandin F2α is an endogenous metabolite present in Urine that can be used for the research of Asthma.
    9α,11β-Prostaglandin F2α-d4
  • HY-130138A
    (5S,6R)-DiHETE 82948-88-7 98%
    (5S,6R)-DiHETE is an enantiomer of (5,6)-DiHETEs. (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC50 of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists.
    (5S,6R)-DiHETE
  • HY-130138B
    (5S,6R)-DiHETEs 129263-59-8 98%
    (5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE (HY-130138A). (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC50 of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists.
    (5S,6R)-DiHETEs
  • HY-130320B
    Monophosphoryl lipid A Triethylamine 98%
    Monophosphoryl lipid A (Triethylamine) is a toll-like receptor 4 agonist. Monophosphoryl lipid A (Triethylamine) is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A (Triethylamine) can be used for the research of immunization and vaccine.
    Monophosphoryl lipid A Triethylamine
  • HY-131002A
    DPTIP hydrochloride 2361799-64-4 98%
    DPTIP hydrochloride is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM.
    DPTIP hydrochloride
  • HY-131103R
    Phenylethanolamine A (Standard) 1346746-81-3
    Phenylethanolamine A (Standard) is the analytical standard of Phenylethanolamine A. This product is intended for research and analytical applications. Phenylethanolamine A acts as a β-adrenergic agonist. Phenylethanolamine A is a byproduct during the Ractopamine synthesis process.
    Phenylethanolamine A (Standard)
  • HY-131103S
    Phenylethanolamine A-d3 2507994-61-6
    Phenylethanolamine A-d3 is a deuterium labeled Phenylethanolamine A. Phenylethanolamine A acts as a β-adrenergic agonist. Phenylethanolamine A is a byproduct during the Ractopamine synthesis process.
    Phenylethanolamine A-d3
  • HY-131515R
    Tri-Salicylic acid (Standard) 85531-17-5
    Tri-Salicylic acid (Standard) is the analytical standard of Tri-Salicylic acid (HY-131515). This product is intended for research and analytical applications. Tri-Salicylic acid (Compound III) is a compound with similar properties to salicylic acid. Tri-Salicylic acid can be used in the research of inflammation, obesity, diabetes, and cardiovascular disease.
    Tri-Salicylic acid (Standard)
  • HY-131579R
    Deschloro Cetirizine dihydrochloride (Standard) 83881-54-3
    Pyrocatechuic acid (Standard) is the analytical standard of Pyrocatechuic acid. This product is intended for research and analytical applications. Pyrocatechuic acid is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion.
    Deschloro Cetirizine dihydrochloride (Standard)
  • HY-131688R
    2-Chlorohexadecanoic acid (Standard) 19117-92-1
    Neomycin (sulfate) (Standard) is the analytical standard of Neomycin (sulfate). This product is intended for research and analytical applications. Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis.
    2-Chlorohexadecanoic acid (Standard)
  • HY-131910A
    (R)-IHMT-PI3Kδ-372 2429889-62-1 99.75%
    (R)-IHMT-PI3Kδ-372 (R-18) is a potent and selective PI3Kδ inhibitor with an IC50 of 19 nM. (R)-IHMT-PI3Kδ-372 (R-18) can be used in chronic obstructive pulmonary disease (COPD) research.
    (R)-IHMT-PI3Kδ-372
  • HY-131914B
    EST64454 maleate 2088272-67-5 98%
    EST64454 maleate is a highly soluble σ1 receptor antagonist, demonstrating potent antinociceptive properties for pain treatment. EST64454 maleate exhibits excellent metabolic stability across various species and possesses an adequate pharmacokinetic profile in rodents. EST64454 maleate has been identified as a promising clinical candidate due to its favorable aqueous solubility and high permeability in Caco-2 cells.
    EST64454 maleate
  • HY-132187S
    Sphingosylphosphorylcholine-d9 2315262-28-1 99.0%
    Sphingosylphosphorylcholine-d9 is deuterium labeled Sphingosylphosphorylcholine.
    Sphingosylphosphorylcholine-d9
  • HY-132269S
    Isoflupredone-d5 98%
    Isoflupredone-d5 is deuterium-labeled Isoflupredone (HY-132269).
    Isoflupredone-d5
  • HY-132280R
    Tirilazad (Standard) 110101-66-1
    Tirilazad (U 74006F free base) Standard is the analytical standard of Tirilazad (HY-132280). This product is intended for research and analytical applications. Tirilazad (U 74006F free base) is a neuroprotective agent. Tirilazad can also bind tightly to the main protease of the COVID-19 virus and exert anti-SARS-CoV-2 activity. Tirilazad scavenges hydroxyl and lipid peroxyl free radicals and maintains the levels of endogenous antioxidants. Tirilazad reduces cerebral infarct volume and improves neurobehavioral scores in animal models of focal ischemia. Tirilazad can be used in research related to ischemic stroke and subarachnoid hemorrhage.
    Tirilazad (Standard)
  • HY-132304A
    (1S,4R)-CC-90005 99.95%
    (1S,4R)-CC-90005 is the (1S,4R)-enantiomer of CC-90005 (HY-132304). CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50 = 4440 nM). CC-90005 can inhibit T cell activation by inhibiting IL-2 expression.
    (1S,4R)-CC-90005
Cat. No. Product Name / Synonyms Application Reactivity