2. Neurological Disease

Neurological Disease (神経疾患)

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

製品番号 製品名 CAS 番号 純度 構造式
  • HY-W721517
    Gabapentin-d10 1126623-20-8 98%
    Gabapentin-d10 is the deuterium labeled Gabapentin (HY-A0057). Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain.
    Gabapentin-d10
  • HY-W721681
    Dehydro nicardipine 59875-58-0 98%
    Dehydro nicardipine is a dihydropyridine metabolite of Nicardipine (HY-12515) and belongs to the dihydropyridine class of compounds. Dehydro nicardipine can selectively inhibit the aggregation of Aβ monomers, specifically regulate the extension and binding of Aβ soluble aggregates, change the morphology of Aβ aggregates, and inhibit the growth of aggregate length. Dehydro nicardipine can be used in the study of Alzheimer's disease (AD).
    Dehydro nicardipine
  • HY-W722128
    Olivetolic acid-d9 2417095-97-5 98%
    Olivetolic acid-d9 is the deuterium labeled Olivetolic acid (HY-W090292). Olivetolic acid is a biosynthetic precursor of cannabinol acid (CBGA). Olivetolic acid has anticonvulsant activity.
    Olivetolic acid-d9
  • HY-W724128
    Cariprazine N-oxide 1084891-96-2 98%
    Cariprazine N-oxide (Compound DP-3) is the mono-oxidative degradation product of Cariprazine hydrochloride (HY-14763A). Cariprazine hydrochloride exhibits antipsychotic activity.
    Cariprazine N-oxide
  • HY-W724221
    3-Methoxyeticyclidine hydrochloride 98%
    3-Methoxyeticyclidine hydrochloride is a phencyclidine-type compound that has binding affinity for the N-methyl-D-aspartate receptor. 3-Methoxyeticyclidine hydrochloride has a certain degree of toxicity.
    3-Methoxyeticyclidine hydrochloride
  • HY-W725182
    3,4-Dichloro-α-pyrrolidinoisohexanophenone hydrochloride 98%
    3,4-Dichloro-α-pyrrolidinoisohexanophenone (3,4-Dichloro-α-PiHP) hydrochloride is an analogue of a psychoactive substance.
    3,4-Dichloro-α-pyrrolidinoisohexanophenone hydrochloride
  • HY-W725194
    4-Fluoro deschloroketamine hydrochloride 3048183-53-2 98%
    4-Fluoro deschloroketamine (4-FDCK) hydrochloride (Page 145) is an amine cyclohexane compound, with its (R)-configuration being Blixeprodil (HY-172419) (an NMDA receptor antagonist). 4-Fluoro deschloroketamine hydrochloride can be used for the study of depression.
    4-Fluoro deschloroketamine hydrochloride
  • HY-W725496
    D-Fructose 6-phosphate dipotassium 103213-47-4 98%
    D-Fructose 6-phosphate dipotassium is an endogenous metabolite in saliva that affects cell growth and autophagy; it can be hydrolyzed by Fructose-1,6-bisphosphatase (FBPase). D-Fructose 6-phosphate dipotassium can be converted into D-glucose 6-phosphate (HY-112537) by the action of phosphoglucose isomerase. D-Fructose 6-phosphate dipotassium is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose 6-phosphate dipotassium can be used to study Lewy body dementia.
    D-Fructose 6-phosphate dipotassium
  • HY-W725737
    BrP-LPA 944313-05-7 98%
    BrP-LPA is a LPA antagonist/ATX inhibitor. BrP-LPA shows pan-antagonist activity towards LPA1-4 GPCRs. BrP-LPA decreases blood vessel density. BrP-LPA dose-dependently inhibits Lysophosphatidic acid-induced head-dip counts. BrP-LPA exhibits anticancer activity against breast cancer, colon cancer, and lung cancer. BrP-LPA inhibits anxiety-like behavior.
    BrP-LPA
  • HY-W727031
    2-Methylamino-1-phenylbutane hydrochloride 84952-63-6 99.28%
    2-Methylamino-1-phenylbutane hydrochloride is a metabolite of stimulant agents in blood.
    2-Methylamino-1-phenylbutane hydrochloride
  • HY-W728451
    URB694 904672-77-1 98%
    URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH.
    URB694
  • HY-W736861
    N-Phthaloylglutamic acid 3227-01-8 98%
    N-Phthaloylglutamic acid is a partial agonist NMDA receptor with a Ki of 13 μM targeting Glu binding-site.
    N-Phthaloylglutamic acid
  • HY-W738587
    Threo-dihydrobupropion-d9 hydrochloride 2747918-83-6 98%
    rac-threo-Dihydro Bupropion Hydrochloride-d9 is the deuterium labeled Threo-dihydrobupropion hydrochloride (HY-131479). Threo-dihydrobupropion hydrochloride is a primary metabolite of Bupropion. Threo-dihydrobupropion hydrochloride can be used for the research of the depression, behavioral, and biochemistry.
    Threo-dihydrobupropion-d9 hydrochloride
  • HY-W739289
    Californidine perchlorate 17939-31-0 98%
    Californidine perchlorate is an orally active γ-aminobutyric acid (GABA) receptor and serotonin receptor modulator. Californidine perchlorate enhances GABA-mediated chloride influx and inhibits cytochrome P450 enzymes. Californidine perchlorate is promising for research of anxiety.
    Californidine perchlorate
  • HY-W740123
    8-Hydroxy mianserin 57257-81-5 98%
    8-Hydroxy mianserin is a synthetic metabolite of Mianserin (HY-B0188). 8-Hydroxy mianserin serves as a precursor for the chemical synthesis of mianserin metabolite derivatives.
    8-Hydroxy mianserin
  • HY-W740977
    4-Methyl-1-pentanol-d7 1246819-30-6 98%
    4-Methyl-1-pentanol-d7 (Isohexanol-d7) is the deuterium labeled 4-Methyl-1-pentanol (HY-W007511). 4-Methyl-1-pentanol is a volatile aroma component of red wine, which is often used in the production and blending of wine. 4-Methyl-1-pentanol can also be used as an alcohol antagonist to antagonize the effects of ethanol and 1-butanol on cell-cell adhesion, and is used in the study of fetal alcohol syndrome.
    4-Methyl-1-pentanol-d7
  • HY-W741434
    Acetophenazine dimaleate-d4 1331636-00-0 98%
    Acetophenazine dimaleate-d4 is the deuterium labeled Acetophenazine (dimaleate) (HY-B1262). Acetophenazine dimaleate, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine dimaleate primarily blocks dopamine D2 receptors in the brain. Acetophenazine dimaleate can be used for researching psychotic disorders such as schizophrenia and anxious depression.
    Acetophenazine dimaleate-d4
  • HY-W742404
    Bopindolol-d9 1794891-82-9 98%
    Bopindolol-d9 ((±)-Bopindolol-d9) is the deuterium labeled Bopindolol (HY-B1562). Bopindolol ((±)-Bopindolol) is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is a proagent of Pindolol (HY-B0982). Bopindolol can be used for essential and renovascular hypertension research.
    Bopindolol-d9
  • HY-W742532
    ETH-LAD 65527-62-0 98%
    ETH-LAD (N-Ethyl-nor-LSD) is an activator for 5-HT2A receptor with Ki of 5.1 nM. ETH-LAD exhibits affinity for dopamine receptor D1 and dopamine receptor D2 with Ki of 22.1 nM and 4.4 nM. ETH-LAD acts as psychoactive substance in rat model.
    ETH-LAD
  • HY-W742955
    Pargeverine hydrochloride 2765-97-1 98%
    Pargeverine hydrochloride is an antispasmodic opioid alkaloid. Pargeverine hydrochloride has a moderate and non-selective blockade of muscarinic cholinergic fibers. Pargeverine hydrochloride can be used in the research of painful spasms.
    Pargeverine hydrochloride
製品番号 製品名 / Synonyms Application Reactivity