2. TGF-beta/Smad
  3. TGF-β Receptor
  4. SLLK, Control Peptide for TSP1 Inhibitor

SLLK, Control Peptide for TSP1 Inhibitor 

Cat. No.: HY-P0301 Purity: 99.70%
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Handling Instructions Technical Support

SLLK, Control Peptide for TSP1 Inhibitor is a control peptide for LSKL (leucine-serine-lysine-leucine).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

SLLK, Control Peptide for TSP1 Inhibitor

SLLK, Control Peptide for TSP1 Inhibitor Chemical Structure

CAS No. : 2918768-29-1

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Other Forms of SLLK, Control Peptide for TSP1 Inhibitor:

SLLK, Control Peptide for TSP1 Inhibitor Related Antibodies

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  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

SLLK, Control Peptide for TSP1 Inhibitor is a control peptide for LSKL (leucine-serine-lysine-leucine).

In Vivo

TGF-β1 is significantly lower (0.10±0.01 pg/mL) in the plasma of mice receiving LSKL compared with that in plasma of mice receiving SLLK control peptide at day 42 (0.20±0.02 pg/mL; P=0.0001). mRNA expression is assessed in the suprarenal aortic lysates obtained from mice receiving SLLK and LSKL peptides[1]. Akita mice treated with 30 mg/kg LSKL have significantly increased nephrin expression, greater than twofold, compared with renal lysates from either saline controls or SLLK-treated mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

458.60

Formula

C21H42N6O5
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ser-Leu-Leu-Lys-NH2
Sequence Shortening

SLLK-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (109.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1805 mL 10.9027 mL 21.8055 mL
5 mM 0.4361 mL 2.1805 mL 4.3611 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
Animal Administration
[2]

Sterile solutions of LSKL or SLLK peptide are made in stock solutions of 3.0 mg/mL (high dose) or 0.3 mg/mL (low dose) in sterile saline. The i.p. injection of LSKL, SLLK, or saline began 2 weeks after uninephrectomy and continues thrice weekly for 15 weeks. For the low-dosage treatment regimen, each group of 20 mice receives 3 mg/kg body weight of peptide (LSKL or SLLK) per injection or saline (100 μL/10 g body weight per injection). For the high-dosage treatment regimen, Akita mice ae given i.p. injections of LSKL or SLLK peptide at 30 mg/kg body weight per injection or saline (100 μL/10 g body weight per injection).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1805 mL 10.9027 mL 21.8055 mL 54.5137 mL
5 mM 0.4361 mL 2.1805 mL 4.3611 mL 10.9027 mL
10 mM 0.2181 mL 1.0903 mL 2.1805 mL 5.4514 mL
15 mM 0.1454 mL 0.7268 mL 1.4537 mL 3.6342 mL
20 mM 0.1090 mL 0.5451 mL 1.0903 mL 2.7257 mL
25 mM 0.0872 mL 0.4361 mL 0.8722 mL 2.1805 mL
30 mM 0.0727 mL 0.3634 mL 0.7268 mL 1.8171 mL
40 mM 0.0545 mL 0.2726 mL 0.5451 mL 1.3628 mL
50 mM 0.0436 mL 0.2181 mL 0.4361 mL 1.0903 mL
60 mM 0.0363 mL 0.1817 mL 0.3634 mL 0.9086 mL
80 mM 0.0273 mL 0.1363 mL 0.2726 mL 0.6814 mL
100 mM 0.0218 mL 0.1090 mL 0.2181 mL 0.5451 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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SLLK, Control Peptide for TSP1 Inhibitor Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLLK, Control Peptide for TSP1 Inhibitor2918768-29-1TGF-β ReceptorTransforming growth factor beta receptorsInhibitorinhibitorinhibit

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