1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Saredutant

Saredutant (Synonyms: SR 48968; SR 48968C)

Cat. No.: HY-106910 Purity: 99.30%
Handling Instructions

Saredutant is a selective NK2 receptor antagonist.

For research use only. We do not sell to patients.

Saredutant Chemical Structure

Saredutant Chemical Structure

CAS No. : 142001-63-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 425 In-stock
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Saredutant is a selective NK2 receptor antagonist.

IC50 & Target

NK2

 

In Vivo

Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant has dose-dependent effects on swim test immobility, with the low dose of 1 mg/kg having no effect and the doses of 3 and 10 mg/kg significantly reducing immobility[1].

Clinical Trial
Molecular Weight

552.53

Formula

C₃₁H₃₅Cl₂N₃O₂

CAS No.

142001-63-6

SMILES

CC(NC1(C2=CC=CC=C2)CCN(CC[[email protected]@H](C3=CC(Cl)=C(Cl)C=C3)CN(C)C(C4=CC=CC=C4)=O)CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (452.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8099 mL 9.0493 mL 18.0986 mL
5 mM 0.3620 mL 1.8099 mL 3.6197 mL
10 mM 0.1810 mL 0.9049 mL 1.8099 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.76 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.76 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Rats[1]
In the first experiment the dose-related effects of Saredutant are investigated. The Flinders Sensitive Line (FSL) rats (n=8) are treated with one of the following: vehicle (carboxymethylcellulose-CMC) or 1, 3, or 10 mg/kg Saredutant, or 5 mg/kg Desipramine as a positive control. Saredutant is injected at 1 mL/kg. The Flinders Resistant Line (FRL) rats are given CMC or 3 mg/kg Saredutant. All injections are i.p. and are given for 14 consecutive days. Approximately 22 h after the last injections the rats are placed in the social interaction chamber with similarly treated rats for a 5-min recording. Then about 2 h later the rats are individually tested in the forced swim test for a single 5-min session[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

SaredutantSR 48968 SR 48968CSR48968SR-48968Neurokinin ReceptorNK receptorInhibitorinhibitorinhibit

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Saredutant
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