1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor

Saredutant (Synonyms: SR 48968; SR 48968C)

Cat. No.: HY-106910
Handling Instructions

Saredutant is a selective NK2 receptor antagonist.

For research use only. We do not sell to patients.

Saredutant Chemical Structure

Saredutant Chemical Structure

CAS No. : 142001-63-6

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Saredutant is a selective NK2 receptor antagonist.

IC50 & Target[1]

NK2

 

In Vivo

Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant has dose-dependent effects on swim test immobility, with the low dose of 1 mg/kg having no effect and the doses of 3 and 10 mg/kg significantly reducing immobility[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8099 mL 9.0493 mL 18.0986 mL
5 mM 0.3620 mL 1.8099 mL 3.6197 mL
10 mM 0.1810 mL 0.9049 mL 1.8099 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Rats[1]
In the first experiment the dose-related effects of Saredutant are investigated. The Flinders Sensitive Line (FSL) rats (n=8) are treated with one of the following: vehicle (carboxymethylcellulose-CMC) or 1, 3, or 10 mg/kg Saredutant, or 5 mg/kg Desipramine as a positive control. Saredutant is injected at 1 mL/kg. The Flinders Resistant Line (FRL) rats are given CMC or 3 mg/kg Saredutant. All injections are i.p. and are given for 14 consecutive days. Approximately 22 h after the last injections the rats are placed in the social interaction chamber with similarly treated rats for a 5-min recording. Then about 2 h later the rats are individually tested in the forced swim test for a single 5-min session[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

552.53

Formula

C₃₁H₃₅Cl₂N₃O₂

CAS No.

142001-63-6

SMILES

CC(NC1(C2=CC=CC=C2)CCN(CC[[email protected]@H](C3=CC(Cl)=C(Cl)C=C3)CN(C)C(C4=CC=CC=C4)=O)CC1)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Saredutant
Cat. No.:
HY-106910
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Saredutant

Cat. No.: HY-106910