1. GPCR/G Protein
  2. LPL Receptor

TY-52156 

Cat. No.: HY-19736 Purity: 99.68%
Handling Instructions

TY-52156 is a potent S1P3 receptor antagonist in a competitive manner, and the Ki value is estimated to be 110 nM for S1P3 receptor.

For research use only. We do not sell to patients.

TY-52156 Chemical Structure

TY-52156 Chemical Structure

CAS No. : 934369-14-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg USD 468 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 804 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

    TY-52156 purchased from MCE. Usage Cited in: Oncogene. 2017 Jun 29;36(26):3760-3771.

    G-MDSCs are stimulated with S1P (5 nM), S1pr3 agonist (CYM5541, 10 μM) or S1pr1 agonist (SEW2871, 10 μM) in the presence or absence of S1pr3 antagonist (TY-52156, 10 μM) for 10 h, respectively. GM-CSF mRNA expression is detected by real-time RT–PCR.
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    TY-52156 is a potent S1P3 receptor antagonist in a competitive manner, and the Ki value is estimated to be 110 nM for S1P3 receptor. IC50 value: 110 nM (Ki) Target: S1P3 in vitro: TY-52156 shows submicromolar potency and a high degree of selectivity for S1P3 receptor. TY-52156 is both sensitive and useful as an S1P3 receptor-specific antagonist and reveal that S1P induces vasoconstriction by directly activating S1P3 receptor and through a subsequent increase in [Ca2+]i and Rho activation in vascular smooth muscle cells. TY-52156 has a selective antagonistic effect toward S1P3 receptor. [1] in vivo: TY-52156 Suppresses S1P3 Receptor-Induced Bradycardia In Vivo. the oral administration of TY-52156 inhibits S1P3 receptor-dependent bradycardia. [1]

    References
    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 2.7452 mL 13.7261 mL 27.4522 mL
    5 mM 0.5490 mL 2.7452 mL 5.4904 mL
    10 mM 0.2745 mL 1.3726 mL 2.7452 mL
    Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    364.27

    Formula

    C₁₈H₁₉Cl₂N₃O

    CAS No.

    934369-14-9

    SMILES

    ClC1=CC=C(/N=C(NNC2=CC=C(Cl)C=C2)/C(C(C)(C)C)=O)C=C1

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Product Name:
    TY-52156
    Cat. No.:
    HY-19736
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