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  2. LPL Receptor
  3. TY-52156

TY-52156 

Cat. No.: HY-19736 Purity: 99.96%
Handling Instructions

TY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM.

For research use only. We do not sell to patients.

TY-52156 Chemical Structure

TY-52156 Chemical Structure

CAS No. : 934369-14-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
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10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 468 In-stock
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100 mg USD 804 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    TY-52156 purchased from MCE. Usage Cited in: Oncogene. 2017 Jun 29;36(26):3760-3771.

    G-MDSCs are stimulated with S1P (5 nM), S1pr3 agonist (CYM5541, 10 μM) or S1pr1 agonist (SEW2871, 10 μM) in the presence or absence of S1pr3 antagonist (TY-52156, 10 μM) for 10 h, respectively. GM-CSF mRNA expression is detected by real-time RT–PCR.
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    Description

    TY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM[1].

    IC50 & Target

    Ki: 110 nM (S1P3)[1]

    In Vitro

    TY-52156 inhibits the S1P3 receptor-dependent increase in [Ca2+]i[1].
    TY-52156 shows submicromolar potency and a high degree of selectivity for S1P3 receptor[1].
    TY-52156 (10 μM; 10 min) inhibits S1P-induced p44/p42 MAPK phosphorylation[1].

    Western Blot Analysis[1]

    Cell Line: Chinese hamster ovary K1 cells
    Concentration: 10 μM
    Incubation Time: 10 min
    Result: Inhibited S1P-induced p44/p42 MAPK phosphorylation.
    In Vivo

    TY-52156 (10 mg/kg, 30 mg/kg; p.o.) suppresses S1P3 receptor-induced bradycardia after oral administration in vivo[1].

    Animal Model: Male SD rats (290–340 g)[1]
    Dosage: 10 mg/kg, 30 mg/kg
    Administration: Oral administration
    Result: Inhibited S1P3 receptor-induced bradycardia after oral administration in vivo.
    Molecular Weight

    364.27

    Formula

    C₁₈H₁₉Cl₂N₃O

    CAS No.

    934369-14-9

    SMILES

    ClC1=CC=C(/N=C(NNC2=CC=C(Cl)C=C2)/C(C(C)(C)C)=O)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (274.52 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7452 mL 13.7261 mL 27.4522 mL
    5 mM 0.5490 mL 2.7452 mL 5.4904 mL
    10 mM 0.2745 mL 1.3726 mL 2.7452 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Product Name:
    TY-52156
    Cat. No.:
    HY-19736
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