2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14905
    α-Prumycin hydrochloride
    		Inhibitor
    α-Prumycin hydrochloride is a carbohydrate antibiotic. α-Prumycin hydrochloride has anti-fungal activity and weak anti-individual bacterial activity.
    α-Prumycin hydrochloride
  • HY-B0576R
    Sulfacetamide sodium (Standard)
    		Inhibitor
    Sulfacetamide (Standard) (Sulphacetamide (Standard)) sodium is the analytical standard of Sulfacetamide sodium (HY-B0576). This product is intended for research and analytical applications. Sulfacetamide sodium is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide sodium has antifungal and antibacterial activities.
    Sulfacetamide sodium (Standard)
  • HY-Y0598R
    trans-Chalcone (Standard)
    		Inhibitor
    trans-Chalcone (Standard) is the analytical standard of trans-Chalcone (HY-Y0598). This product is intended for research and analytical applications. trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity.
    trans-Chalcone (Standard)
  • HY-N5204
    Clavalanine
    		Inhibitor
    Clavalanine (Ro 22-5417) inhibits a variety of bacteria and fungi.
    Clavalanine
  • HY-N14839
    Neoenactin B2
    		Inhibitor
    Neoenactin B2 has strong anti-yeastlike and filamentous fungal effects.
    Neoenactin B2
  • HY-163693
    Antifungal agent 104
    		Inhibitor
    Antifungal agent 104 (Compound 5e) exhibits antifungal activity against Sclerotinia sclerotiorum, Rhizoctonia solani and Botrytis cinerea, with EC50 of 1.52 μg/mL, 0.06 μg/mL and 15.69 μg/mL, respectively. Antifungal agent 104 exhibits low cytotoxicity to human renal cell 239A (6.28-100 mM).
    Antifungal agent 104
  • HY-N14809
    Neobulgarone C
    		Inhibitor
    Neobulgarone C is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone C can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone C
  • HY-W705651
    Econazole nitrate-d6
    		Inhibitor
    Econazole nitrate-d6 is deuterium labeled Econazole (nitrate). Econazole nitrate is an imidazole class antifungal medication. Econazole nitrate also has antibacterial activity.
    Econazole nitrate-d<sub>6</sub>
  • HY-N14833
    Naphthoquinomycin B
    		Inhibitor
    Naphthoquinomycin B is an Ansa antibiotic with anti-Gram-positive bacteria and fungi activity, and can inhibit the synthesis of E. coli fatty acids.
    Naphthoquinomycin B
  • HY-183091
    Antifungal agent 159
    		Inhibitor
    Antifungal agent 159 is an antifungal agent with broad-spectrum activity against phytopathogenic fungi. Antifungal agent 159 binds tightly to the active sites of exo-β-(1,3)-glucanase, topoisomerase II-DNA-nucleotide, dihydrofolate reductase, sterol 14-α demethylase and chitin synthase. Antifungal agent 159 can be used in studies related to phytopathogenic fungal infections.
    Antifungal agent 159
  • HY-105267
    LY 121019
    		Inhibitor
    LY 121019 is a semi-synthetic antifungal antibiotic with strong anticandida activity with MIC50 value of 0.625 μg/mL.
    LY 121019
  • HY-169684
    Vaccarin C
    		Inhibitor
    Vaccarin C (Compound VIII) is a cycloheptapeptide with good antifungal activity against pathogenic fungi and dermatophytes M. audouinii and T. mentagrophytes with MIC values of 6 µg/mL. Vaccarin C also has high cytotoxicity against Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines with IC50 values of 3.35 and 5.72 μM, respectively.
    Vaccarin C
  • HY-N13996
    Clavamycin B
    		Inhibitor
    Clavamycin B has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase.
    Clavamycin B
  • HY-N14789
    Amidomycin
    		Inhibitor
    Amidomycin is an antibiotic active primarily against yeast.
    Amidomycin
  • HY-N14254
    Hypelcin A-Ⅰ
    		Inhibitor
    Hypelcin A-I has anti-Gram-negative bacterial and fungal activity.
    Hypelcin A-Ⅰ
  • HY-N0756AR
    (-)-Bornyl acetate (Standard)
    		Inhibitor
    (-)-Bornyl acetate (Standard) is the analytical standard of (-)-Bornyl acetate. This product is intended for research and analytical applications. (-)-Bornyl acetate (L-(-)-Bornyl acetate), isolated from hyssop oil, is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate possesses antifungal activity.
    (-)-Bornyl acetate (Standard)
  • HY-N14027
    Chondramide B
    		Inhibitor
    Chondramide B has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities.
    Chondramide B
  • HY-N7093R
    Furaneol (Standard)
    		Inhibitor
    Furaneol (Standard) is the analytical standard of Furaneol. This product is intended for research and analytical applications. Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines.
    Furaneol (Standard)
  • HY-N7107R
    Fenchyl alcohol (Standard)
    		Inhibitor
    Fenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candida albicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer.
    Fenchyl alcohol (Standard)
  • HY-W714837
    5-Phenyllevulinic acid
    		Inhibitor
    5-Phenyllevulinic acid (4-Oxo-5-phenylpentanoic acid) is an endogenous fungal metabolite with inhibitory activity against the bacterium B. megaterium, the plant pathogenic fungus S. tritici, and the alga C. fusca. 5-Phenyllevulinic acid is also an intermediate in the synthesis of σ receptor ligands. 5-Phenyllevulinic acid holds potential for research in the field of anti-infection studies .
    5-Phenyllevulinic acid
Cat. No. Product Name / Synonyms Application Reactivity