Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (2639)
Antibodies (1)
Related Compound Screening Libraries (1)

By Effects:	Inhibitors (2351)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-133216R

Bupirimate (Standard)	Inhibitor
Bupirimate (Standard) is the analytical standard of Bupirimate (HY-133216). This product is intended for research and analytical applications. Bupirimate is a systemic fungicide that inhibits adenosine deaminase (ADA). Bupirimate is widely used in the cultivation of fruit trees, vegetables, flowers, and other crops to control powdery mildew.

HY-173448

CDA-IN-4	Inhibitor
CDA-IN-4 (compound VS-24) is a chitin deacetylase (CDA) inhibitor. CDA-IN-4 shows a 61.2% protective effect against rice blast at a concentration of 100 μg/mL.

HY-N14582

Glomosporin	Inhibitor
Glomosporin is a cyclic ester peptide antifungal antibiotic, and it has moderate anti-Aspergillus flavus (including Aspergillus Niger and Aspergillus Niger), yeast activity (MIC is 16 μg/mL).

HY-N14434

Pradimicin B	Inhibitor
Pradimicin B is an antibiotic. Pradimicin B has strong antifungal and yeast activity.

HY-12396R

Aminothiazole (Standard)	Inhibitor
Aminothiazole (Standard) is the analytical standard of Aminothiazole. This product is intended for research and analytical applications. Aminothiazole (2-Aminothiazole), a typical heterocyclic amine, is a precursor for the synthesis of biologically active molecules including sulfur agents, biocides, fungicides, antibiotics, dyes and chemical reaction accelerators.

HY-N14991

Acrylamidine	Inhibitor
Acrylamidine has weak anti-mold and yeast activity.

HY-178051

Antifungal agent 135	Inhibitor
Antifungal agent 135 (Compound C2), an antifungal agent, is a Succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 1.99 μM. Antifungal agent 135 has potent antifungal activities against Valsa mali, Sclerotinia sclerotiorum and Phytophthora capsici with EC₅₀ s of 0.280, 1.11 and 0.130 mg/L, respectively. Antifungal agent 135 shows protective and curative activities against Phytophthora capsici and Valsa mali by effectively disrupting hyphal structural integrity and inhibiting mycelial growth.

HY-178346

SDH-IN-33	Inhibitor
SDH-IN-33 (Compound I-9) is a succinate dehydrogenase inhibitor. SDH-IN-33 exhibits excellent fungicidal activity with an EC₅₀ of 0.07 μg/mL. SDH-IN-33 inhibits R. solani succinate dehydrogenase (RsSDH) with an IC₅₀ 0.35 μg/mL. SDH-IN-33 can be used for the study of fungal infection.

HY-N8921

Methoxyanigorufone	Inhibitor
Methoxyanigorufone (compound 4) is a compound that can be isloated from Musa acuminata var. "Yangambi km 5".

HY-N15391

1-Hydroxy-2-nonyn-4-one	Inhibitor
1-hydroxynon-2-yn-4-one is an antibiotic. 1-Hydroxy-2-nonyn-4-one has anti-yeast, filamentous fungus, tumor and weak anti-Gram-positive bacteria and Gram-negative bacteria activity.

HY-N14877

Enactin Ia	Inhibitor
Enactin Ia is found in the strain of Streptomyces roseoviridis. Enactin Ia has only weak antifungal activity.

HY-B1119R

Triclosan (Standard)	Inhibitor
Triclosan (Standard) is the analytical standard of Triclosan. This product is intended for research and analytical applications. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.

HY-P5552

Melimine	Inhibitor
Melimine is a hybrid antimicrobial peptide of Melittin (HY-P0233) and Protamine. Melimine is active against P. aeruginosa and S. aureus. Melimine has broad spectrum activity against bacteria, fungi and protozoa.

HY-N14980

Dermostatin B	Inhibitor
Dermostatin B is a polyene antibiotic with antifungal activity that can be used in the study of fungal infections.

HY-N7116R

Lawsone methyl ether (Standard)	Inhibitor
Lawsone methyl ether (Standard) (2-Methoxy-1,4-naphthoquinone (Standard)) is the analytical standard of Lawsone methyl ether (HY-N7116). This product is intended for research and analytical applications. Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities.

HY-175647

Myosin-5-IN-2	Inhibitor
Myosin-5-IN-2 (Compound G19) is a Myosin-5 inhibitor. Myosin-5-IN-2 has an antifungal activity against Fusarium graminearum (Fg), Botrytis cinerea and Rhizoctonia solani with an EC₅₀ s of 0.326 μg/mL for Fg. Myosin-5-IN-2 has effective protective and curative control efficiency for wheat leaves. Myosin-5-IN-2 severely damages the surface integrity of mycelial cells and induces cytoplasmic leakage. Myosin-5-IN-2 can be used for fungal infections like fusarium head blight (FHB) research.

HY-W013780S1

Fmoc-Pro-OH-¹³C₅,¹⁵N	Inhibitor
Fmoc-Pro-OH-¹³C₅,¹⁵N is a ¹⁵N-labeled and ¹³C-labled Fmoc-Pro-OH (HY-W013780). Fmoc-Pro-OH is a proline derivative.

HY-N2789

(9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol	Inhibitor
(9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a nature product that could be isolated from the ethyl acetate extract of Cassonia barteri (Araliaceae) leaves. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol has antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-123002

Pyrifenox	Inhibitor
Pyrifenox is a fungicide, which is used in fruits, ornamentals, and vegetables. Pyrifenox can be utilized as one of the assessment criteria for environmental and food safety.

HY-181610

SDH-IN-45	Inhibitor
SDH-IN-45 is a succinate dehydrogenase BcSDH inhibitor and mycelial growth inhibitor targeting Botrytis cinerea, with an IC₅₀ of 5.97 μg/mL against Botrytis cinerea. SDH-IN-45 inhibits succinate dehydrogenase, a component of the mitochondrial electron transport chain, via a unique binding mode, thereby regulating fungal energy metabolism. SDH-IN-45 causes morphological damage to Botrytis cinerea mycelia, leading to collapse and shrinkage of mycelial structures. SDH-IN-45 exhibits in vitro fungicidal activity against Botrytis cinerea. SDH-IN-45 can be used in research related to cucumber gray mold.

Antifungal Compound Library

Compound library containing all kinds of molecules with anti-fungal activity.

545compounds HY-L048

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Fungal

Fungal

Fungal Related Products (2639)

Antibodies (1)

Related Compound Screening Libraries (1)

Fungal Related Products (2639):