SDH-IN-45
SDH-IN-45 is a succinate dehydrogenase BcSDH inhibitor and mycelial growth inhibitor targeting Botrytis cinerea, with an IC50 of 5.97 μg/mL against Botrytis cinerea. SDH-IN-45 inhibits succinate dehydrogenase, a component of the mitochondrial electron transport chain, via a unique binding mode, thereby regulating fungal energy metabolism. SDH-IN-45 causes morphological damage to Botrytis cinerea mycelia, leading to collapse and shrinkage of mycelial structures. SDH-IN-45 exhibits in vitro fungicidal activity against Botrytis cinerea. SDH-IN-45 can be used in research related to cucumber gray mold.
For research use only. We do not sell to patients.
- CAS No.: 3112883-32-3
- Formula: C21H16F3NO3
- Molecular Weight:387.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
SDH-IN-45 (compound 4i) (50 μg/mL) inhibits mycelial growth of multiple phytopathogenic fungi, with 75.0 ± 0.5% inhibition against Botrytis cinerea at 50 μg/mL[1].
SDH-IN-45 inhibits Botrytis cinerea succinate dehydrogenase with an IC50 of 5.97 μg/mL[1].
SDH-IN-45 (7 μg/mL; mycelial growth period) causes morphological damage, including collapse and wrinkling, to Botrytis cinerea mycelia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
Chemical Information
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CAS No. 3112883-32-3
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Molecular Weight 387.35
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Formula C21H16F3NO3
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SMILES
O=C(C1=CC=CC=C1C(F)(F)F)NOCC2=CC=CC=C2OC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Filamentous Fungal Mold Culture and Sporulation
Filamentous fungal mold culture and sporulation assays grow hyphae under defined nutritional and environmental conditions until asexual spores, commonly conidia, are produced; the main readouts are colony growth, sporulation onset, conidial yield, conidial morphology, viability, and, when relevant, downstream infectivity or stress phenotype.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SDH-IN-45 Related Classifications
HY-181610 Related Classifications
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