SDH-IN-45 

SDH-IN-45 is a succinate dehydrogenase BcSDH inhibitor and mycelial growth inhibitor targeting Botrytis cinerea, with an IC₅₀ of 5.97 μg/mL against Botrytis cinerea. SDH-IN-45 inhibits succinate dehydrogenase, a component of the mitochondrial electron transport chain, via a unique binding mode, thereby regulating fungal energy metabolism. SDH-IN-45 causes morphological damage to Botrytis cinerea mycelia, leading to collapse and shrinkage of mycelial structures. SDH-IN-45 exhibits in vitro fungicidal activity against Botrytis cinerea. SDH-IN-45 can be used in research related to cucumber gray mold^[1].

SDH-IN-45 (compound 4i) (50 μg/mL) inhibits mycelial growth of multiple phytopathogenic fungi, with 75.0 ± 0.5% inhibition against Botrytis cinerea at 50 μg/mL^[1].
SDH-IN-45 inhibits Botrytis cinerea succinate dehydrogenase with an IC₅₀ of 5.97 μg/mL^[1].
SDH-IN-45 (7 μg/mL; mycelial growth period) causes morphological damage, including collapse and wrinkling, to Botrytis cinerea mycelia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SDH-IN-45 (compound 4i) (200 μg/mL) shows lower in vivo fungicidal activity against multiple crop fungal pathogens^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

387.35

C₂₁H₁₆F₃NO₃

3112883-32-3

O=C(C1=CC=CC=C1C(F)(F)F)NOCC2=CC=CC=C2OC3=CC=CC=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sun Y, et al. Scaffold Hopping Combined with 3D-QSAR for the Discovery of Succinate Dehydrogenase Inhibitors Containing N-Benzyloxyformamide. J Agric Food Chem. 2026;74(5):4273-4281.  [Content Brief]