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Cat. No.: HY-181610

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SDH-IN-45

SDH-IN-45 is a succinate dehydrogenase BcSDH inhibitor and mycelial growth inhibitor targeting Botrytis cinerea, with an IC₅₀ of 5.97 μg/mL against Botrytis cinerea. SDH-IN-45 inhibits succinate dehydrogenase, a component of the mitochondrial electron transport chain, via a unique binding mode, thereby regulating fungal energy metabolism. SDH-IN-45 causes morphological damage to Botrytis cinerea mycelia, leading to collapse and shrinkage of mycelial structures. SDH-IN-45 exhibits in vitro fungicidal activity against Botrytis cinerea. SDH-IN-45 can be used in research related to cucumber gray mold.

For research use only. We do not sell to patients.

CAS No.: 3112883-32-3
Formula: C₂₁H₁₆F₃NO₃
Molecular Weight:387.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SDH-IN-45 Chemical Structure

CAS No.: 3112883-32-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

SDH-IN-45 (compound 4i) (50 μg/mL) inhibits mycelial growth of multiple phytopathogenic fungi, with 75.0% inhibition against Botrytis cinerea at 50 μg/mL^[1].
SDH-IN-45 inhibits Botrytis cinerea mycelial growth with an EC₅₀ of 6.64 μg/mL^[1].
SDH-IN-45 inhibits Botrytis cinerea succinate dehydrogenase with an IC₅₀ of 5.97 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SDH-IN-45 (compound 4i) (200 μg/mL) shows lower in vivo fungicidal activity against multiple crop fungal pathogens^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Filamentous Fungal Mold Culture and Sporulation

Chemical Information

CAS No. 3112883-32-3
Molecular Weight 387.35
Formula C₂₁H₁₆F₃NO₃
SMILES

O=C(C1=CC=CC=C1C(F)(F)F)NOCC2=CC=CC=C2OC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun Y, et al. Scaffold Hopping Combined with 3D-QSAR for the Discovery of Succinate Dehydrogenase Inhibitors Containing N-Benzyloxyformamide. J Agric Food Chem. 2026;74(5):4273-4281. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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