2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-173206
    Antifungal agent 128
    		Inhibitor
    Antifungal agent 128 (Compound 3ja) is an antifungal agent. When used in combination with Fluconazole (HY-B0101), the MIC range against C. albicans strains is 0.5-4 μg/mL. Antifungal agent 128 can be used in the research of the anti-infection field.
    Antifungal agent 128
  • HY-180272
    TMV-IN-15
    		Inhibitor
    MV-IN-15 (compound 4AF) is a potent antiviral and antifungal agent. TMV-IN-15 suppresses viral particle assembly by binding to the TMV-CP, inducing prominent aggregation and structural fusion. TMV-IN-15 exhibits inhibitory activity against Physalospora piricola and Rhizoctonia cereal. TMV-IN-15 can be used for pesticides research.
    TMV-IN-15
  • HY-185177
    Antifungal agent 156
    		Inhibitor
    Antifungal agent 156 (Ex.1-123) is a heterocyclic pyridazine compound and a phytopathogenic fungal control agent, which can be used in studies related to phytopathogenic fungal infection.
    Antifungal agent 156
  • HY-B2058
    Triticonazole
    		Inhibitor
    Triticonazole is an orally active triazole fungicide and androgen receptor antagonist. Triticonazole inhibits testosterone-induced androgen receptor activation and reduces basal testosterone secretion. Prenatal exposure to Triticonazole causes shortened anogenital distance in male rat fetuses and induces organ-specific histopathological changes in pigs. Triticonazole can be used for detoxification of seeds contaminated with fungal pathogens, but there is a risk of animal poisoning if the treated seeds are used as animal feed.
    Triticonazole
  • HY-178778
    SDH-IN-38
    		Inhibitor
    SDH-IN-38 (Compound IIIe) is a Succinate dehydrogenase inhibitor. SDH-IN-38 is an antifungal agent, with an EC50 value of 0.009 μg/mL against R. solani mycelia. SDH-IN-38 inhibits mycelial growth by affecting mycelial respiration. SDH-IN-38 induces cellular senescenc and reduces mitochondrial membrane potential in mycelia.
    SDH-IN-38
  • HY-173528
    Antimicrobial agent-40
    		Inhibitor
    Antimicrobial agent-40 (Compound 5a) has antimicrobial activity against fungi, Gram-negative and Gram-positive bacteria. Antimicrobial agent-40 has good cytotoxicity against MCF-7 cells (IC50: 33.52 μM) and exhibits anticancer activity.
    Antimicrobial agent-40
  • HY-N15042
    9-Hydroxyoudemansin A
    		Inhibitor
    9-Hydroxyoudemansin A is an antibiotic. 9-Hydroxyoudemansin A has antifungal activity, has an MIC of 12.5 μg/mL against ochre-like yeast, and is resistant to fungi such as Candida albicans, Crimson Yeast, Penicillium and Streptomyces with MICs are all> 50 μg/mL. No anti-bacterial effect.
    9-Hydroxyoudemansin A
  • HY-W020043R
    Pyribencarb (Standard)
    		Inhibitor
    Pyribencarb (Standard) is the analytical standard of Pyribencarb. This product is intended for research and analytical applications. Pyribencarb is a benzylcarbamate-type fungicide, which is active against a wide range of plant pathogenic fungi. Pyribencarb is a potent Qo inhibitor of cytochrome b. Pyribencarb is especially active against Botrytis cinerea and Sclerotinia sclerotirum.
    Pyribencarb (Standard)
  • HY-N14282
    Ezomycin B2
    		Inhibitor
    Ezomycin B2 is an antibiotic with antifungal activity.
    Ezomycin B2
  • HY-N16672
    SMTP-0
    		Inhibitor
    SMTP-0 (ent-Stachybotrin B) is an enantiomer of Stachybotrin B isolated from Stachybotrys microspora. SMTP-0 is the simple homologues of the SMTP nonlysine-analog plasminogen modulator family but shows no plasminogen modulator activity. SMTP-0 exhibits antibacterial and antifungal effects. SMTP-0 can be used for the research of infection.
    SMTP-0
  • HY-100069R
    Fluazinam impurity 1 (Standard)
    		Inhibitor
    Fluazinam impurity 1 (Standard) is the analytical standard of Fluazinam impurity 1. This product is intended for research and analytical applications. Fluazinam impurity 1 is an impurity of Fluazinam with antifungal activity. Fluazinam impurity 1 is active against Sphaerotheca fuliginea, Pyricularia oryzae and Rhizoctonia solani.
    Fluazinam impurity 1 (Standard)
  • HY-76200C
    (R,R)-Voriconazole
    		Inhibitor
    (R,R)-Voriconazole ((R,R)-UK-109496) is an enantiomer of Voriconazole (HY-76200). Voriconazole (UK-109496) is a second-generation broad-spectrum triazole antifungal compound that inhibits the biosynthesis of fungal ergosterol. Voriconazole exerts its antifungal activity by inhibiting the 14-α-lanosterol demethylation mediated by fungal cytochrome P450 enzymes. Voriconazole exhibits blood-brain barrier permeability.
    (R,R)-Voriconazole
  • HY-B1858R
    Isoprothiolane (Standard)
    		Inhibitor
    Isoprothiolane (Standard) is the analytical standard of Isoprothiolane (HY-B1858). This product is intended for research and analytical applications. Isoprothiolane is a blast fungicide with antifungal, anti-inflammatory and insecticidal activities. Isoprothiolane primarily acts on fungi during the penetration and growth stages of infecting hyphae. Isoprothiolane can be used as an insecticide, pesticide, etc. In addition, Isoprothiolane can reduce serum phospholipid and total lipid concentrations, regulating lipid metabolism. Isoprothiolane is also used in the research of fatty liver.
    Isoprothiolane (Standard)
  • HY-120734R
    Quinoxyfen (Standard)
    		Inhibitor
    Quinoxyfen (Standard) is the analytical standard of Quinoxyfen. This product is intended for research and analytical applications. Quinoxyfen (DE-795) is a powdery mildew fungicide.
    Quinoxyfen (Standard)
  • HY-N14023
    Glidobactin G
    		Inhibitor
    Glidobactin G is an anti-tumor antibiotic. Glidobactin G has the activity against pathogenic fungi and yeast. Glidobactin G also extends the survival of mice inoculated with leukemia P388 cells.
    Glidobactin G
  • HY-105477
    Maniwamycin A
    		Inhibitor
    Maniwamycin A ((-)-Maniwamycin A) has anti-fungal effect.
    Maniwamycin A
  • HY-B0518AS
    Naftifine-d3 hydrochloride
    		Inhibitor
    Naftifine-d3 (hydrochloride) is the deuterium labeled Naftifine hydrochloride. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition.
    Naftifine-d<sub>3</sub> hydrochloride
  • HY-N13282
    Glyceocarpin
    		Inhibitor
    Glyceocarpin is a phytoalexin and antibacterial agent naturally occurring in Glycine max, with weak antifungal activity. Glyceocarpin serves as the biosynthetic precursor of Glyceollins II (HY-N18032) and Glyceollins III. Glyceocarpin can be biosynthesized by the prenyltransferase and subsequent modification by cytochrome P450 enzymes. Glyceocarpin can be used for the study of soybean root and stem rot caused by Phytophthora sojae.
    Glyceocarpin
  • HY-17395S1
    Terbinafine-d5 hydrochloride
    		Inhibitor
    Terbinafine-d5 (TDT 067-d5) hydrochloride is deuterium-labeled Terbinafine hydrochloride (HY-17395).
    Terbinafine-d<sub>5</sub> hydrochloride
  • HY-N14213
    Polyoxin H
    		Inhibitor
    Polyoxin H is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin H
Cat. No. Product Name / Synonyms Application Reactivity