2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-169919
    HDM-IN-1
    		Inhibitor
    HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model.
    HDM-IN-1
  • HY-N15453
    Asperenone
    		Inhibitor
    Asperenone is an inhibitor of 15-lipoxygenase (15-LOX) with an IC50 value of 0.3 mM. It is also an inhibitor of platelet aggregation, with an IC50 value of 0.23 mM. Additionally, Asperenone has antifungal activity and can inhibit the growth of pathogenic fungi Ophiostoma crassivaginatum and O. piliferum. Asperenone can be used in the research of cardiovascular diseases and anti-infection fields.
    Asperenone
  • HY-126724
    Flutianil
    		Inhibitor
    Flutianil is a fungicide, which specifically inhibits the powdery mildew species. Flutianil inhibits the haustorium formation and subsequent mycelia growth.
    Flutianil
  • HY-N12808
    (E)-4-Methyl-5-styrylbenzene-1,3-diol
    		Inhibitor
    (E)-4-Methyl-5-styrylbenzene-1,3-diol (Compound III) is an antifungal agent and can be extracted from Dracaena cochinchinensis (Lour.) S. C. Chen.
    (E)-4-Methyl-5-styrylbenzene-1,3-diol
  • HY-146024
    Antifungal agent 28
    		Inhibitor
    Antifungal agent 28 (compound 18) is a potent and selective antifungal agent. Antifungal agent 28 inhibits pathogenic strains of C. albicans and non-albicans species including fluconazole-resistant strains. Antifungal agent 28 inhibits Cryptococcus and Aspergillus strains. Antifungal agent 28 disrupts mature Candida biofilm.
    Antifungal agent 28
  • HY-N6687R
    Calcimycin (Standard)
    		Inhibitor
    Calcimycin (Standard) is the analytical standard of Calcimycin. This product is used for research and analytical applications. Calcimycin is an antibiotic and a unique divalent cation ionophore, such as calcium ions and magnesium ions. Calcimycin induces Ca2+ -dependent cell death by increasing the intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi, and also inhibits the activity of ATPase and uncouples the oxidative phosphorylation (OXPHOS) of mammalian cells, inducing apoptosis and autophagy.
    Calcimycin (Standard)
  • HY-157459
    SDH-IN-11
    		Inhibitor
    SDH-IN-11 (compound A7) is a SDH inhibitor, and shows inhibitory effect on nematode feeding, reproductive ability, and egg hatching. SDH-IN-11 promotes the oxidative stress of nematodes and causes intestinal damage to nematodes. SDH-IN-11 inhibits the activity of succinate dehydrogenase (SDH) in nematodes.
    SDH-IN-11
  • HY-N14179
    Cytovaricin
    		Inhibitor
    Cytovaricin has the activity of inhibiting Yoshida sarcoma cells and has weak anti-phytopathogenic fungi and chlorella activity.
    Cytovaricin
  • HY-126484
    Eremofortin B
    		Inhibitor
    Eremofortin B is a sesquiterpenoid compound synthesized by penicillium roqueforti PR Toxin (PRT).
    Eremofortin B
  • HY-N14524
    Gladiolic acid
    		Inhibitor
    Gladiolic acid has the antifungal activity of Absidia glauca Hagem, garlic spores, Byssochlamys fulva, Trichophyton mentagrophytes, Corpuscular falciparum.
    Gladiolic acid
  • HY-N14211
    Polyoxin F
    		Inhibitor
    Polyoxin F is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin F
  • HY-180672
    Antifungal agent 145
    		Inhibitor
    Antifungal agent 145 (Compound 14') is a highly effective fungicide. Antifungal agent 145 exhibits MICs against Candida albicans, Candida tropicalis, and Cryptococcus neoformans of 4, 8, and 8 μg/mL respectively. Antifungal agent 145 exerts a potent and rapid bactericidal effect by disrupting the fungal cell membrane, and can effectively inhibit and destroy biofilms. Antifungal agent 145 has improved safety and can be used in antifungal research.
    Antifungal agent 145
  • HY-166670S
    Ketoconazole carbonyl-13C
    		Inhibitor
    Ketoconazole carbonyl-13C (Ketoconazol-13C) is 13C labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
    Ketoconazole carbonyl-<sup>13</sup>C
  • HY-135422
    Nidulin
    		Inhibitor
    Nidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candida albicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp.
    Nidulin
  • HY-N15024
    Eupenoxide
    		Inhibitor
    Eupenoxide is an antibiotic with antifungal activity that can be found by fungi of the genus Eupenicillium.
    Eupenoxide
  • HY-N9754
    Cyclosporin L
    		Inhibitor
    Cyclosporin L is a cyclosporin that can be found in Tolypocladium inflatum, with moderate immunosuppressive and antifungal activities.
    Cyclosporin L
  • HY-Y1667R
    2,6-Dibromophenol (Standard)
    		Inhibitor
    2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca2+ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC50 of 2.78 mg/L for Daphnia magna and a 96 h EC50 of 9.90 mg/L for algae (Scenedesmus quadricauda).
    2,6-Dibromophenol (Standard)
  • HY-N0672R
    Pseudolaric Acid C (Standard)
    		Inhibitor
    Pseudolaric Acid C (Standard) is the analytical standard of Pseudolaric Acid C. This product is intended for research and analytical applications. Pseudolaric C is a diterpenoid isolated from the root bark of Pseudolarix amabilis, has antifungal activity.
    Pseudolaric Acid C (Standard)
  • HY-N10318
    Erigeside II
    		Inhibitor
    Erigeside II is a sesquiterpene glycoside found in the root bark of Dictamnus dasycarpus. Erigeside II stimulates the proliferation of T-cells.
    Erigeside II
  • HY-101424
    2-Chloro-N-(2-methyl-4-bromophenyl)acetamide
    		Inhibitor
    2-Chloro-N-(2-methyl-4-bromophenyl)acetamide is an antifungal compound.
    2-Chloro-N-(2-methyl-4-bromophenyl)acetamide
Cat. No. Product Name / Synonyms Application Reactivity