2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156195
    BHBM
    		Inhibitor
    BHBM (compound 1) is an aromatic acylhydrazone antifungal agent with high bactericidal activity against Cryptococcus neoformans.
    BHBM
  • HY-163634
    YZK-C22
    		Inhibitor
    YZK-C22, containing a 1,2,3-thiadiazol-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole skeleton, is a fungicide lead compound with broad-spectrum fungicidal activity.
    YZK-C22
  • HY-N14817
    Neocopiamycin B
    		Inhibitor
    Neocopiamycin B is found in the strain of Str. hygroscopicus var. crystallogenes. Neocopiamycin B has antifungal activity.
    Neocopiamycin B
  • HY-W715372
    Pyraoxystrobin
    		Inhibitor
    Pyraoxystrobin is a QoI fungicide, with an EC50 of 0.0094 μg/mL for M. oryzae isolates. Pyraoxystrobin can be used for the research of M. oryzae in rice fields.
    Pyraoxystrobin
  • HY-170885
    Group II intron-IN-1
    		Inhibitor
    Group II intron-IN-1 (Compound 1) is an inhibitor of fungal Group II introns, with an IC50 of 3 μM. Group II intron-IN-1 can be used for research on infections caused by fungi such as Candida.
    Group II intron-IN-1
  • HY-W326159
    Giparmen
    		Inhibitor
    Giparmen is an anti-tubercular agent. Giparmen is promising for research of fungal infections, particularly Candida.
    Giparmen
  • HY-W175598
    Bis(4-morpholinyl)methane
    		Inhibitor
    Bis(4-morpholinyl)methane (N,N'-Methylene-bis-morpholine) is a broad-spectrum, slow-release formaldehyde-based fungicide. Bis(4-morpholinyl)methane inhibits the growth and reproduction of microorganisms, and prevents spoilage and odor generation in humid environments. Bis(4-morpholinyl)methane serves as a preservative for natural rubber latex.
    Bis(4-morpholinyl)methane
  • HY-161049
    Antifungal agent 89
    		Inhibitor
    Antifungal agent 89 (compound 28) is a antifungal agent against Cryptococcus neoformans with minimum inhibitory concentration value ranging from 0.8 to 52.17 μM.
    Antifungal agent 89
  • HY-N14220
    Epoformin
    		Inhibitor
    Epoformin, is a fungal cyclohexene epoxide that can be isolated from Diplodia quercivora. Epoformin is an antibiotic and exhibits weak inhibitory activity against rye seedling sheath growth. Epoformin exhibits antifungal activity, inhibits Phytophthora cinnamomi and Phytophthora plurivora.
    Epoformin
  • HY-179139
    SDH-IN-40
    		Inhibitor
    SDH-IN-40 (compound A7) is a succinate dehydrogenase inhibitor (SDHI). SDH-IN-40 exhibits strong inhibitory effects on F. graminearum (IC50 = 34.33 μM). SDH-IN-40 can be used for research on fungal infections.
    SDH-IN-40
  • HY-N14155
    Epelmycin A
    		Inhibitor
    Epelmycin A has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.
    Epelmycin A
  • HY-B0614AR
    Mafenide Acetate (Standard)
    		Inhibitor
    Mafenide (Acetate) (Standard) is the analytical standard of Mafenide Acetate (HY-B0614A). This product is intended for research and analytical applications. Mafenide Acetate is a potent sulfonamide antimicrobial agent. Mafenide Acetate exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Mafenide Acetate also exhibits antifungal activity against filamentous fungi (e.g., Lichtheimia and Aspergillus flavus). Mafenide Acetate can be used in the research of skin grafts on burn wounds, post-traumatic invasive fungal infections, and bacterially contaminated wounds.
    Mafenide Acetate (Standard)
  • HY-161457
    (Gly0.8Nap0.2)20
    		Inhibitor
    (Gly0.8Nap0.2)20 is a compound that dual targets fungal membranes and DNA. (Gly0.8Nap0.2)20 has antibacterial activity.
    (Gly0.8Nap0.2)20
  • HY-173342
    Neocryptolepine-Cl
    		Inhibitor
    Neocryptolepine-Cl (compound Z24) is an inhibitor of Bcthi4 and exhibits excellent antifungal activity against B. cinerea with EC50 value of 0.56 μg/mL.
    Neocryptolepine-Cl
  • HY-178457
    SDH-IN-34
    		Inhibitor
    SDH-IN-34 is a Succinate Dehydrogenase inhibitor with antifungal activity. SDH-IN-34 can be used for the research of infection.
    SDH-IN-34
  • HY-N12497
    Moracin B
    		Inhibitor
    Moracin B is a phytoalexin with antifungal activity. Moracin B can be isolated from the cortex and phloem tissues of mulberry (Morus alba Linne) infected with Fusarium solani f. sp. mori. Moracin B can be used to study plant disease resistance mechanisms against microbial infections, particularly showing potential application value in the field of plant disease control.
    Moracin B
  • HY-174353S
    CYP51-IN-23-d3
    		Inhibitor
    CYP51-IN-23-d3 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum. CYP51-IN-23-d3 can prevent fungal phase transformation and biofilm formation. CYP51-IN-23-d3 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-23-d3 can be used for the study of invasive fungal infections (IFIs).
    CYP51-IN-23-d<sub>3</sub>
  • HY-138194
    Destomycin B
    		Inhibitor
    Destomycin B (A-16316-C) is an antibiotic, and is active against fungi. Destomycin B also has anthelmintic activity.
    Destomycin B
  • HY-118451
    Lanomycin
    		Inhibitor
    Lanomycin is an antifungal compound with activity against Candida and dermatophytes.
    Lanomycin
  • HY-N13025
    8-Acetylverrucarin L
    		Inhibitor
    8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candida albicans and Geotrichum candidum.
    8-Acetylverrucarin L
Cat. No. Product Name / Synonyms Application Reactivity