2. シグナル伝達
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

製品番号 製品名 製品効果 純度 構造式
  • HY-106541R
    Neticonazole (Standard) Inhibitor
    Neticonazole (Standard) is the analytical standard of Neticonazole. This product is intended for research and analytical applications. Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects.
    Neticonazole (Standard)
  • HY-N15600
    Merulidial Inhibitor
    Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively .
    Merulidial
  • HY-183872
    FTR1335 Inhibitor
    FTR1335 is an Antifungal agent as well as a selective, substrate peptide-competitive, and myristoyl-CoA non-competitive inhibitor of N-myristoyltransferase CaNmt, with an IC50 of 0.49 nM against Candida albicans CaNmt. FTR1335 exhibits fungicidal activity against Candida albicans and inhibits the growth of Candida tropicalis. FTR1335 can be used in research related to Candida albicans infections.
    FTR1335
  • HY-117092
    BE-31405 Inhibitor
    BE-31405 is an antifungal antibiotic. BE-31405 can be isolated from the culture broth of the fungal strains such as Penicillium minioluteum F31405, Talaromyces siamensis FKA-61, and Phomopsis sp. FKA-62. BE-31405 exhibits potent growth inhibitory activity against pathogenic fungal strains including Candida albicans, Candida glabrata, and Cryptococcus neoformans. BE-31405 shows no cytotoxicity against mammalian cells.
    BE-31405
  • HY-136355R
    Picoxystrobin (Standard) Inhibitor
    Picoxystrobin (Standard) is the analytical standard of Picoxystrobin (HY-136355). This product is intended for research and analytical applications. Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity.
    Picoxystrobin (Standard)
  • HY-12638R
    Dichlorophen (Standard) Inhibitor
    Dichlorophen (Standard) is the analytical standard of Dichlorophen (HY-12638). This product is intended for research and analytical applications. Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections.
    Dichlorophen (Standard)
  • HY-N8432R
    Dipyrithione (Standard) Inhibitor
    Dipyrithione (Standard) is the analytical standard of Dipyrithione (HY-N8432). This product is intended for research and analytical applications. Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis.
    Dipyrithione (Standard)
  • HY-N14679
    Pinselin Inhibitor
    Pinselin is a nitrogen-containing heterocyclic antibiotic. Pinselin has anti-yeast activity.
    Pinselin
  • HY-136425R
    Fosetyl-aluminum (Standard) Inhibitor
    Fosetyl-aluminum (Standard) is the analytical standard of Fosetyl-aluminum. This product is intended for research and analytical applications. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops.
    Fosetyl-aluminum (Standard)
  • HY-N14956
    Fulvoferruginin Inhibitor
    Fulvoferruginin showed cytotoxicity and antifungal activity, especially to Paecilomyces varioti.
    Fulvoferruginin
  • HY-N14192
    Maltophilin Inhibitor
    Maltophilin is a broad-spectrum antifungal antibiotic that has no antibacterial effect against Gram-positive and Gram-negative bacteria.
    Maltophilin
  • HY-122480
    Fenaminstrobin Inhibitor
    Fenaminstrobin (SYP-1620) is a strobilurin Fungicide. Fenaminstrobin binds to cytochrome bc1 in the mitochondrial respiratory chain, thereby inhibiting ATP production. Fenaminstrobin exhibits acute toxicity to Daphnia magna. Fenaminstrobin effectively controls diseases such as Fusarium ear rot, downy mildew, rice blast and pear scab.
    Fenaminstrobin
  • HY-N15091
    Formamicin Inhibitor
    Formamicin has broad spectrum and strong anti-plant pathogenic fungi activity.
    Formamicin
  • HY-N3006R
    Sakuranetin (Standard) Inhibitor
    Sakuranetin is a cherry flavonoid phytoalexin, shows strong antifungal activity. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury.
    Sakuranetin (Standard)
  • HY-N14441
    Haliangicin A Inhibitor
    Haliangicin A has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
    Haliangicin A
  • HY-N17348
    5,6,7,8-Tetramethoxyflavone Inhibitor
    5,6,7,8-Tetramethoxyflavone is a flavonoid with antifungal and antibacterial activities, capable of inhibiting the growth of *Staphylococcus aureus* and *Candida albicans*. 5,6,7,8-Tetramethoxyflavone can be utilized in research related to infections [1].
    5,6,7,8-Tetramethoxyflavone
  • HY-N6805A
    (E)-Isoeugenol acetate Inhibitor
    (E)-Isoeugenol acetate, a Eugenol derivative, possesses antifungal activity.
    (E)-Isoeugenol acetate
  • HY-N6013R
    Aloin (mixture of A&B) (Standard) Inhibitor
    Aloin (mixture of A&B) (Standard) is the analytical standard of Aloin (mixture of A&B) (HY-N6013). This product is intended for research and analytical applications. Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma.
    Aloin (mixture of A&B) (Standard)
  • HY-178108
    Anti-MRSA agent 35 Inhibitor
    Anti-MRSA agent 35 (Compound 6b) is an anti-MRSA agent. Anti-MRSA agent 35 significantly inhibits MRSA biofilm formation, suppresses penicillin-binding protein (PBP2a) expression and induces mecA virulence gene mutation. Anti-MRSA agent 35 has potent bactericidal and fungicidal activities with MIC50s of 7.8-31.25 μg/mL for gram positive bacteria, gram-negative bacteria and Fungi. .
    Anti-MRSA agent 35
  • HY-W744966R
    Mandipropamid (Standard) Inhibitor
    Mandipropamid (Standard) is the analytical standard of Mandipropamid. This product is intended for research and analytical applications. Mandipropamid displays outstanding activity against late blight diseases of potato and tomato, combined with excellent efficacy on downy mildew diseases of grape and cucumber.
    Mandipropamid (Standard)
製品番号 製品名 / Synonyms Application Reactivity