FTR1335 

FTR1335 is an Antifungal agent as well as a selective, substrate peptide-competitive, and myristoyl-CoA non-competitive inhibitor of N-myristoyltransferase CaNmt, with an IC₅₀ of 0.49 nM against Candida albicans CaNmt. FTR1335 exhibits fungicidal activity against Candida albicans and inhibits the growth of Candida tropicalis. FTR1335 can be used in research related to Candida albicans infections^[1][2][3].

FTR1335 (24 h) potently inhibits growth of Candida albicans and Candida tropicalis, but has a narrow antifungal spectrum with no activity against other tested fungal species^[1].
FTR1335 is a highly potent, selective inhibitor of fungal N-myristoyltransferase^[1].
FTR1335 (0-1.5 nM; 10 min) potently and selectively inhibits purified Candida albicans N-myristoyltransferase (CaNmt) with an IC₅₀ of 0.49 nM, acting as a competitive inhibitor for the peptide substrate and non-competitive inhibitor for myristoyl-CoA, while showing minimal activity against human N-myristoyltransferase 1 (HsNmt1) (IC₅₀ = 5400 nM)^[2].
FTR1335 (variable concentrations; 48-72 h) exhibits fungicidal activity against Candida albicans ATCC 90028 (MFC = 0.78 μM) and inhibits growth of most C. albicans isolates (including fluconazole-resistant strains) and Candida tropicalis in vitro, but shows no activity against other tested non-albicans Candida, Aspergillus, Trichophyton, or Cryptococcus species^[2].
FTR1335 potently inhibits Candida albicans N-myristoyltransferase with an IC₅₀ of 0.49 nM and inhibits Candida albicans growth with an MIC of 0.78 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

526.69

C₃₁H₃₄N₄O₂S

851075-79-1

O=C(C1CCCC1)NC(SC2=C3)=NC2=CC=C3NC([C@H]4C[C@H](CCC4)NCC5=CC6=C(C=CC=C6)C=C5)=O

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• [1]. Liu Y, et al. Novel benzothiazole derivatives with a broad antifungal spectrum: Design, synthesis and structure–activity relationships[J]. MedChemComm, 2013, 4(12): 1551-1561.

  [2]. Ebara S, et al. FTR1335 is a novel synthetic inhibitor of Candida albicans N-myristoyltransferase with fungicidal activity. Biol Pharm Bull. 2005;28(4):591-595.

  [3]. Sheng C, et al. New lead structures in antifungal drug discovery. Curr Med Chem. 2011;18(5):733-766.