FTR1335

FTR1335 (24 h) potently inhibits growth of Candida albicans and Candida tropicalis, but has a narrow antifungal spectrum with no activity against other tested fungal species^[1].
FTR1335 is a highly potent, selective inhibitor of fungal N-myristoyltransferase^[1].
FTR1335 (0-1.5 nM; 10 min) potently and selectively inhibits purified Candida albicans N-myristoyltransferase (CaNmt) with an IC₅₀ of 0.49 nM, acting as a competitive inhibitor for the peptide substrate and non-competitive inhibitor for myristoyl-CoA, while showing minimal activity against human N-myristoyltransferase 1 (HsNmt1) (IC₅₀ = 5400 nM)^[2].
FTR1335 (variable concentrations; 48-72 h) exhibits fungicidal activity against Candida albicans ATCC 90028 (MFC = 0.78 μM) and inhibits growth of most C. albicans isolates (including fluconazole-resistant strains) and Candida tropicalis in vitro, but shows no activity against other tested non-albicans Candida, Aspergillus, Trichophyton, or Cryptococcus species^[2].
FTR1335 potently inhibits Candida albicans N-myristoyltransferase with an IC₅₀ of 0.49 nM and inhibits Candida albicans growth with an MIC of 0.78 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.