851075-79-1
Chemical Structure
FTR1335
- CAS No.: 851075-79-1
- Formula:C31H34N4O2S
- Molecular Weight:526.69
InChIKey: DJBPAGGSUSAEKT-RPBOFIJWSA-N
SMILES: O=C(C1CCCC1)NC(SC2=C3)=NC2=CC=C3NC([C@H]4C[C@H](CCC4)NCC5=CC6=C(C=CC=C6)C=C5)=O
Biological Activity: FTR1335 is an Antifungal agent as well as a selective, substrate peptide-competitive, and myristoyl-CoA non-competitive inhibitor of N-myristoyltransferase CaNmt, with an IC50 of 0.49 nM against Candida albicans CaNmt. FTR1335 exhibits fungicidal activity against Candida albicans and inhibits the growth of Candida tropicalis. FTR1335 can be used in research related to Candida albicans infections[1][2][3].
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FTR1335 | FTR1335 is an Antifungal agent as well as a selective, substrate peptide-competitive, and myristoyl-CoA non-competitive inhibitor of N-myristoyltransferase CaNmt, with an IC50 of 0.49 nM against Candida albicans CaNmt. FTR1335 exhibits fungicidal activity against Candida albicans and inhibits the growth of Candida tropicalis. FTR1335 can be used in research related to Candida albicans infections. | |||||||||||||||||||||
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- [1]. Liu Y, et al. Novel benzothiazole derivatives with a broad antifungal spectrum: Design, synthesis and structure–activity relationships[J]. MedChemComm, 2013, 4(12): 1551-1561.
- [2]. Ebara S, et al. FTR1335 is a novel synthetic inhibitor of Candida albicans N-myristoyltransferase with fungicidal activity. Biol Pharm Bull. 2005;28(4):591-595. [Content Brief]
- [3]. Sheng C, et al. New lead structures in antifungal drug discovery. Curr Med Chem. 2011;18(5):733-766. [Content Brief]
Keywords
