2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123474
    PF-1163B
    		Inhibitor
    PF-1163B is an antifungal antibiotic.
    PF-1163B
  • HY-W103773
    2-Phenylphenol sodium
    		Inhibitor 99.67%
    2-Phenylphenol sodium is a phenolic disinfectant and toxic agent with bactericidal, fungicidal and growth-inhibiting activities. 2-Phenylphenol sodium serves as a post-harvest agricultural fungicide and food preservative. At specific concentrations, 2-Phenylphenol sodium inhibits the growth of E. coli strains, while at high concentrations, 2-Phenylphenol sodium completely blocks their proliferation. 2-Phenylphenol sodium acts as a substrate for biocatalytic conversion, and is converted to 3-phenylcatechol by 2-hydroxybiphenyl 3-monooxygenase in recombinant E. coli. 2-Phenylphenol sodium also undergoes electrochemical oxidation in phosphate buffer solution.
    2-Phenylphenol sodium
  • HY-162953
    Laccase-IN-4
    		Inhibitor
    Laccase-IN-4 (compund 5g) exhibits significant Laccase inhibitory activity.
    Laccase-IN-4
  • HY-164643
    Antifungal agent 113
    		Inhibitor
    Antifungal agent 113 (compound 9a) is a potent antifungal and antibacterial agent. Antifungal agent 113 shows good antibacterial activity against S. aureus and methicillin-resistant S. aureus.
    Antifungal agent 113
  • HY-155167
    Anticancer agent 151
    		Inhibitor
    Anticancer agent 151 (compound 6C) is an anticancer agent. Anticancer agent 151 exhibits excellent in vitro cytotoxic activity against MCF-7 cells with an IC50 value of 6.3 μM.
    Anticancer agent 151
  • HY-N14066
    Ascochitine
    		Inhibitor
    Ascochitine, a polyketide-derived secondary metabolite, is a selective antifungal agent. Ascochitine exhibits broad-spectrum phytotoxicity and antimicrobial activities.
    Ascochitine
  • HY-136757
    CYP51-IN-7
    		Inhibitor
    CYP51-IN-2 (compound 1g), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 250 ng/mL for Microsporum gypseum and Candida albicans, respectively.
    CYP51-IN-7
  • HY-121633
    Kayahope
    		Inhibitor
    Kayahope is a fungal inhibitor.
    Kayahope
  • HY-100373R
    Isavuconazonium sulfate (Standard)
    		Inhibitor
    Isavuconazonium (sulfate) (Standard) is the analytical standard of Isavuconazonium (sulfate) (HY-100373). This product is intended for research and analytical applications. Isavuconazonium sulfate (BAL8557-002) is an orally active broad-spectrum antifungal molecule. Isavuconazonium sulfate is a precursor of the triazole antifungal active molecule Isavuconazole. Isavuconazonium sulfate can be used in the study of invasive aspergillosis, mucormycosis, blastomycosis, and Acanthamoeba keratitis.
    Isavuconazonium sulfate (Standard)
  • HY-121395
    Lepiochlorin
    		Inhibitor
    Lepiochlorin is an antibiotic metabolite produced by a fungus (Lepiota species) that is cultivated by ants, which can prevent fungal contamination.
    Lepiochlorin
  • HY-N14216
    Polyoxin L
    		Inhibitor
    Polyoxin L is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin L
  • HY-17520R
    Penthiopyrad (Standard)
    		Inhibitor
    Penthiopyrad (Standard) is the analytical standard of Penthiopyrad. This product is intended for research and analytical applications. Penthiopyrad (MTF-753) is a chiral carboxamide antifungal agent with a broad spectrum of fungicidal activity. Penthiopyrad can be used for controlling foliar and soil-borne plants diseases on a broad range of agricultural crops and turfgrass.
    Penthiopyrad (Standard)
  • HY-14272S
    Ravuconazole-d4
    		Inhibitor
    Ravuconazole-d4 is the deuterium labeled Ravuconazole. Ravuconazole (BMS-207147) is an orally available triazoleantifungle agent that potently inhibits a wide range of fungi.
    Ravuconazole-d<sub>4</sub>
  • HY-N14318
    Feigrisolide B
    		Inhibitor
    Feigrisolide B is a lactone found in Streptomyces griseus. Feigrisolide B has the activity of resisting Sporobolomyces ochreata and inhibiting CoxsacKie virus B3. Feigrisolide B also has moderate inhibitory activity of 3α-hydroxysterol dehydrogenase.
    Feigrisolide B
  • HY-N8511
    Acremine I
    		Inhibitor
    Acremine I is a fungi inhibitor and also a metabolite of the endophytic fungus Acremonium byssoides. Acremine I can effectively inhibit Plasmopara viticola. Acremine I can be used for research on plant diseases, such as grape downy mildew.
    Acremine I
  • HY-105751
    Kalafungin
    		Inhibitor
    Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria.
    Kalafungin
  • HY-119683R
    Epoxiconazole (Standard)
    		Inhibitor
    Epoxiconazole (Standard) is the analytical standard of Epoxiconazole. This product is intended for research and analytical applications. Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases.
    Epoxiconazole (Standard)
  • HY-N15107
    Polyoxin M
    		Inhibitor
    Polyoxin M is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin M
  • HY-138210
    N,O-Diacetyltyramine
    		Inhibitor
    N,O-Diacetyltyramine is a compound with antibacterial activity and cytotoxicity that can be isolated from the actinomycete Pseudonocardia endophytica VUK-10. N,O-Diacetyltyramine has antibacterial activity against Gram-positive and Gram-negative bacteria and fungi. N,O-Diacetyltyramine is cytotoxic to MDA-MB-231, HeLa, MCF-7 and OAW-42 cells.
    N,O-Diacetyltyramine
  • HY-179287
    SDH-IN-42
    		Inhibitor
    SDH-IN-42 (Compound D28) is a SDH (IC50: 5.38 μg/mL) inhibitor and antifungal agent. SDH-IN-42 exerts antifungal activity against R. solani by disrupting mycelial morphology, increasing cell membrane permeability, inducing the production and accumulation of ROS, and impairing mitochondrial function.
    SDH-IN-42
Cat. No. Product Name / Synonyms Application Reactivity