Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2736)
Related Products (2736)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Pipercroside A
0 ImagesCat. No.: HY-N15528CAS No.: 3053945-91-5Pipercroside A is found in Piper crocatum Ruiz & Pav. Pipercroside A is a CYP51 inhibitor. Pipercroside A has antifungal activity.
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Dehydrogriseofulvin
0 ImagesCat. No.: HY-W741556CAS No.: 3573-90-8Dehydrogriseofulvin can be isolated from Penicillium sp. Dehydrogriseofulvin inhibits Colletotrichum musae with MIC > 1 µg/scrip.
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Climbazole (Standard)
0 ImagesCat. No.: HY-B1151RCAS No.: 38083-17-9Synonyms: BAY-e 6975 (Standard)Climbazole (Standard) is the analytical standard of Climbazole. This product is intended for research and analytical applications. Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450.
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Cystothiazole A
0 ImagesCat. No.: HY-N14135CAS No.: 207399-36-8Cystothiazole A has antifungal activity. Cystothiazole A can inhibit candida albicans, saccharomyces cerevisiae and aspergillus smoke with MIC values of 0.4 μg/mL, 0.1 μg/mL and 1.6 μg/mL, respectively. Cystothiazole A also inhibits human tumor cell, such as HPT-116 and K562 cells with MIC values of 130 ng/mL and 110 ng/mL, respectively. Cystothiazole A has no anti-bacterial effect.
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Acetylgliotoxin
0 ImagesCat. No.: HY-183421CAS No.: 146016-64-0Synonyms: Gliotoxin monoacetateAcetylgliotoxin (Gliotoxin monoacetate) is a farnesyltransferase (FTase) inhibitor with an IC50 of 4.4 μM against human targets. Acetylgliotoxin inhibits the growth of fungal, bacterial, and viral pathogens; it binds to free protein thiols and induces ROS production. Acetylgliotoxin increases the survival rate of Caenorhabditis elegans infected with Candida albicans, but exhibits toxicity at higher concentrations. Acetylgliotoxin is applicable to research related to Candida albicans infections.
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(Rac)-Lateritin
0 ImagesCat. No.: HY-121407ACAS No.: 2180287-51-6(Rac)-Lateritin is an acyl-CoA:cholesterol acyltransferase (ACAT/SOAT) inhibitor, with IC50 values of 5.7 μM and 5.6 μM in rat liver, respectively. (Rac)-Lateritin exerts time-dependent irreversible enzyme inhibition that persists even after microsomal washing. (Rac)-Lateritin inhibits cholesterol ester formation in macrophages without altering triglyceride synthesis or other steps in oxidized low-density lipoprotein metabolism. (Rac)-Lateritin inhibits the growth of cancer cells, Gram-positive bacteria, and Candida albicans. (Rac)-Lateritin can be used in studies related to atherosclerosis, human solid tumors, mouse lymphocytic leukemia, as well as fungal and bacterial infections.
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4-Isopropylbenzoic acid (Standard)
0 ImagesCat. No.: HY-W013571RCAS No.: 536-66-3Synonyms: Cuminic acid (Standard); p-Isopropyl benzoic acid (Standard)4-Isopropylbenzoic acid (Cuminic acid; p-Isopropyl benzoic acid) an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid exhibits antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive inhibitor of mushroom tyrosinase.
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Prolylrapamycin
0 ImagesCat. No.: HY-135445CAS No.: 156223-31-3Synonyms: 21-NorrapamycinProlylrapamycin (21-Norrapamycin) is the derivative of Rapamycin (HY-10219). Prolylrapamycin exhibits antifungal activity, that inhibits Candida albicans, Saccharomyces cerevisiae, and Fusarium oxysporum with MIC of 0.125-2 μg/mL.
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Candicidin (≥50%)
0 ImagesCat. No.: HY-108874ACAS No.: 1403-17-4Synonyms: Levorin (≥50%); Vanobid (≥50%); Candimon (≥50%)Candicidin (≥50%) (Levorin (≥50%)) is an Antifungal antibiotic. Candicidin (≥50%) exhibits potent antifungal activity against yeasts and yeast-like fungi, such as Candida albicans and Saccharomyces cerevisiae. Low concentrations of Candicidin (≥50%) do not adversely affect pea seed germination.
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Antifungal agent 133
0 ImagesCat. No.: HY-176483Antifungal agent 133 (compound D2) is an orally active antifungal agent with a MIC80 of 0.13 ug/mL against C.neoformans H99. Antifungal agent 133 can be used for study of cryptococcal meningitis.
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Fosfluconazole (Standard)
0 ImagesCat. No.: HY-100666RCAS No.: 194798-83-9Fosfluconazole (Standard) is the analytical standard of Fosfluconazole. This product is intended for research and analytical applications. Fosfluconazole is a proagent of Fluconazole that is widely used as an antifungal agent.
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Hyalodendrin
0 ImagesCat. No.: HY-138100CAS No.: 51920-94-6Synonyms: (+)-HyalodendrinHyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice.
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Procymidone (Standard)
0 ImagesCat. No.: HY-B1884RCAS No.: 32809-16-8Procymidone (Standard) is the analytical standard of Procymidone. This product is intended for research and analytical applications. Procymidone, a pesticide, is an immunogen hapten that can be combined with cOVA (carrier protein) to produce polyclonal antibodies. Procymidone has antifungal activity.
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Iodiconazole
0 ImagesCat. No.: HY-111201CAS No.: 887138-63-8Synonyms: ADKZIodiconazole (ADKZ) is a new antifungal compound.
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Halofantrine hydrochloride (Standard)
0 ImagesCat. No.: HY-A0148ARCAS No.: 36167-63-2Synonyms: SKF-102886 (Standard); WR-171669 hydrochloride (Standard)Halofantrine hydrochloride (Standard) is the analytical standard of Halofantrine hydrochloride. This product is intended for research and analytical applications. Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent. Halofantrine hydrochloride inhibits the Cap1-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.
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Graveoline (Standard)
0 ImagesGraveoline (Standard) is the analytical standard of Graveoline (HY-12538). This product is intended for research and analytical applications. Graveoline (Rutamine) is an orally active alkaloid with various activities such as antifungal, antiparasitic, anti-inflammatory, and antitumor effects. Graveoline can induce tumor cell apoptosis and autophagy through a reactive oxygen species-mediated pathway. Graveoline has an MIC of 500 μg/mL for Candida albicans. Graveoline can be used in the research of various diseases such as tumors and liver injury.
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Quindecamine acetate
0 ImagesCat. No.: HY-163688CAS No.: 19146-62-4Quindecamine acetate is a derivative of Quinaldine. Quindecamine acetate has antifungal activity.
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Amycolatopsin B
0 ImagesCat. No.: HY-N13156CAS No.: 2209112-97-8Amycolatopsin B (compound 2) is a glycosylated polyketide macrolide with antifungal activity that was isolated from the soil isolate Amycolatopsis sp. MST-108494.
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Neoenactin A
0 ImagesCat. No.: HY-N14838CAS No.: 88231-85-0Neoenactin A has strong anti-yeastlike and filamentous fungal effects.
