2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-126602
    Kinamycin B
    		Inhibitor
    Kinamycin B is an antibiotic found in Streptomyces murayamaensis of the genus Streptomyces that exhibits antifungal activity.
    Kinamycin B
  • HY-N14435
    Pradimicin Q
    		Inhibitor
    Pradimicin Q is an antibiotic. The cytotoxicity (IC50) to human colon HCT-116 cells and murine melanoma B16-F10 cells are 75 and 100 μg/mL, respectively.
    Pradimicin Q
  • HY-B0277R
    Vidarabine (Standard)
    		Inhibitor
    Vidarabine (Ara-A) (Standard) is the analytical standard of Vidarabine. This product is intended for research and analytical applications. Vidarabine is a nucleoside antibiotic isolated from Streptomyces, and a metabolite of Vidarabine phosphate (HY-B0277A). Vidarabine selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis.
    Vidarabine (Standard)
  • HY-14283S1
    Luliconazole-d3
    		Inhibitor
    Luliconazole-d3 (NND 502-d3) is deuterium labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al.
    Luliconazole-d<sub>3</sub>
  • HY-59097
    (E/Z)-Tapinarof
    		Inhibitor
    (E/Z)-Tapinarof ((E/Z)-WBI-1001; 3,5-dihydroxy-4-isopropylstilbene) is a broad-spectrum antibiotic. (E/Z)-Tapinarof has anti-bacterial, anti-fungal and anti-nematode activities.
    (E/Z)-Tapinarof
  • HY-N14044
    Crocacin D
    		Inhibitor
    Crocacin D has anti-yeast and filamentous fungal activity. Crocacin D can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin D can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum.
    Crocacin D
  • HY-N14269
    Ezomycin A2
    		Inhibitor
    Ezomycin A2 is an antifungal antibiotic. Ezomycin A2 is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on Sclerotinia, Botrytis and Candidiasis of crops.
    Ezomycin A2
  • HY-N15056
    Chainin
    		Inhibitor
    Chainin has anti-yeast and Aspergillus Niger fungal activity.
    Chainin
  • HY-163891
    Antifungal agent 107
    		Inhibitor
    Antifungal agent 107 (compound b24) is an OSBP inhibitor with antifungal activity. Antifungal agent 107 can be used to control cucumber downy mildew and potato late blight in greenhouse.
    Antifungal agent 107
  • HY-113863
    Rilopirox
    		Inhibitor
    Rilopirox (HOE 351) is a hydroxy-pyridone compound with antimycotic properties. Rilopirox, a chelating agent, can inhibit catalase. Rilopirox inhibits the respiratory chain. Rilopirox inhibits growth of yeast isolates with a MIC50 of 4 μg/mL. Rilopirox has the potential for vaginal candidosis and oropharyngeal Candida infections research.
    Rilopirox
  • HY-N15288
    Cavipetin C
    		Inhibitor
    Cavipetin C is a diterpene that can be isolated from B. cavipes. Cavipetin C exhibits antifungal activity that blocks the Cladosporium cucumericum spore formation.
    Cavipetin C
  • HY-W093399S
    Ammonium bicarbonate-15N
    		Inhibitor
    Ammonium bicarbonate-15N is the 15N labeled isotope of Ammonium bicarbonate,AR,99% (HY-W093399). Ammonium bicarbonate,AR,99% is an analytical reagent-grade ammonium bicarbonate. Ammonium bicarbonate has antifungal activity. Ammonium bicarbonate is widely used in laboratory analysis, food processing, agricultural fertilization and other fields.
    Ammonium bicarbonate-<sup>15</sup>N
  • HY-N14212
    Polyoxin G
    		Inhibitor
    Polyoxin G is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin G
  • HY-N14737
    Dunaimycin A1
    		Inhibitor
    Dunaimycin A1 is a 24-membered macrolide compound with immunosuppressive activity and antifungal activity against Aspergillus niger. Dunaimycin A1 is promising for research of autoimmune diseases.
    Dunaimycin A1
  • HY-N14436
    Pradimicin Tl
    		Inhibitor
    Pradimicin T1 is an antibiotic. Pradimicin Tl has activity against filamentous fungi and yeast-like fungi.
    Pradimicin Tl
  • HY-N14604
    Chandrananimycin B
    		Inhibitor
    Chandrananimycin B has anti-mucor activity, as well as anti-tumor cell activity such as CCL HT29, MFXF 529L, MACL McF-7.
    Chandrananimycin B
  • HY-122448A
    (Rac)-Sativan
    		Inhibitor
    (Rac)-Sativan is an isoflavanoid with a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi. (Rac)-Sativan exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 µg/mL.
    (Rac)-Sativan
  • HY-139161R
    Penflufen (Standard)
    		Inhibitor
    Penflufen (Standard) is the analytical standard of Penflufen. This product is intended for research and analytical applications. Penflufen is a highly efficient, broad-spectrum succinate dehydrogenase inhibitor (SDHI). Penflufen can be used as a fungicide and has broad bioactivity against many fungal diseases, including potato black scurf, wheat sharp eyespot, rice sheath blight, and root rot in peanut and other similar fungal diseases.
    Penflufen (Standard)
  • HY-107772
    NC-1175 hydrochloride
    		Inhibitor
    NC-1175 hydrochloride is an antifungal agent targeting cell membrane H+-ATPase. NC-1175 hydrochloride can be used for the research of infection.
    NC-1175 hydrochloride
  • HY-W104752
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol
    		Inhibitor 99.34%
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol (Compound 3n) is an antimicrobial and antioxidant agent, that inhibits Escherichia coli and Staphylococcus epidermidis, with MIC of 8 and 4 μg/mL. 5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol exhibits antioxidant activity with IC50 of 17.47 μM using DPPH free radical-scavenging method.
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol
Cat. No. Product Name / Synonyms Application Reactivity