2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-136758
    CYP51-IN-8
    		Inhibitor
    CYP51-IN-2 (compound 1h), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 15.6 and 62.5 ng/mL for Microsporum gypseum and Candida albicans, respectively.
    CYP51-IN-8
  • HY-163631
    Antibacterial agent 218
    		Inhibitor
    Antibacterial agent 218 (compound d28) is an orally active sterol 24-C-Methyltransferase inhibitor with the IC50 of 0.273 μM. Antibacterial agent 218 shows antifungal activity against the C.albicans SC5314 with the IC50 of 0.25 μg/mL.
    Antibacterial agent 218
  • HY-N13151
    3-GlcA-28-AraRhaxyl-medicagenate
    		Inhibitor
    3-GlcA-28-AraRhaxyl-medicagenate is an insect toxin belonging to the saponin family. 3-GlcA-28-AraRhaxyl-medicagenate exhibits antifungal activity and causes mortality in rice weevils at doses down to 0.1 mg/mL.
    3-GlcA-28-AraRhaxyl-medicagenate
  • HY-N14812
    Neobulgarone E
    		Inhibitor
    Neobulgarone E is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone E can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone E
  • HY-117424
    Inz-4
    		Inhibitor
    Inz-4 is a fungal-selective inhibitor of mitochondrial cytochrome bc1, with the IC50 of 0.026 μM.
    Inz-4
  • HY-B1843R
    Fuberidazole (Standard)
    		Inhibitor
    Fuberidazole (Standard) is the analytical standard of Fuberidazole. This product is intended for research and analytical applications. Fuberidazole (BAY 33172; Furidazole) is a fungicide. Fuberidazole shows a synergistic effect with cucurbituril (CB) macromolecules, such as CB7 and CB8. Studies have shown that, CB8 induces pKa shifts on Fuberidazole. Fuberidazole significantly inhibits the growth of B. cinerea.
    Fuberidazole (Standard)
  • HY-119683S1
    Epoxiconazole-d4
    		Inhibitor
    Epoxiconazole-d4 is the deuterium labeled Epoxiconazole (HY-119683). Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases.
    Epoxiconazole-d<sub>4</sub>
  • HY-114717
    Pterophyllin 2
    		Inhibitor
    Pterophyllin 2 is a fungicide against R. stolonifer with a MFC value of 250 μg/mL. Pterophyllin 2 also has antifungal activity against B. cinerea and M. fructicola.
    Pterophyllin 2
  • HY-N14488
    Nemotinic acid
    		Inhibitor
    Nemotinic acid has the activity against Gram-positive bacteria, mycobacterium and fungus, and also against Gram-negative bacteria, but the activity is weak.
    Nemotinic acid
  • HY-N1063R
    Xanthoxylin (Standard)
    		Inhibitor
    Xanthoxylin (Xanthoxyline) can be isolated from Zanthoxylum simulans. Xanthoxylin has antifungal and antioxidant effects. The MIC of Xanthoxylin against Toxoplasma neonatorum and Aspergillus fumigatus were 50 µg/mL and 75 µg/mL, respectively. Xanthoxylin can be used in the study of anti-epileptic diseases.
    Xanthoxylin (Standard)
  • HY-115441
    (Rac)-Luliconazole
    		Inhibitor
    (Rac)-Luliconazole ((Rac)-NND 502) is the racemic isomer of Luliconazole (HY-14283). Luliconazole is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity.
    (Rac)-Luliconazole
  • HY-B1211R
    Dehydroacetic acid (Standard)
    		Inhibitor
    Dehydroacetic acid (Standard) (Biocide 470F (Standard)) is the analytical standard of Dehydroacetic acid (HY-B1211). This product is intended for research and analytical applications. Dehydroacetic acid (Biocide 470F) is a pyrone derivative. Dehydroacetic acid has antibacterial, antifungal and phytotoxic activities. Dehydroacetic acid can be added to cosmetics, food and beverages for preservation and other purposes. Dehydroacetic acid can also be used to synthesize various heterocycles and cycloaddition products.
    Dehydroacetic acid (Standard)
  • HY-174394S
    CYP51-IN-25
    		Inhibitor
    CYP51-IN-25 is a orally active broad spectrum antifungal agent with the MIC80 of 0.00625-0.05 μg/mL. is a CYP51-IN-25 is a deuterated compound with antibiotic properties. CYP51-IN-25 can inhibit the fungal CYP51 enzyme, block ergosterol synthesis, and disrupt cell membrane integrity. CYP51-IN-25 can be used for research on fungal infections.
    CYP51-IN-25
  • HY-N4136R
    Lonicerin (Standard)
    		Inhibitor
    Lonicerin (Standard) (Veronicastroside (Standard)) is the analytical standard of Lonicerin (HY-N4136). This product is intended for research and analytical applications. Lonicerin is a flavonoid with multiple biological activities. Lonicerin inhibits xanthine oxidase with an IC50 of 37.4 µg/mL. Lonicerin inhibits alginate secretion protein (AlgE). Lonicerin inhibits P. aeruginosa and C. albicans. Lonicerin has anti-inflammatory, anti-arthritic, antioxidant, antifungal, anti-bacterial, and neuroprotective properties.
    Lonicerin (Standard)
  • HY-P10916
    Micafungin metabolite M1
    		Inhibitor
    Micafungin metabolite M1 is an active metabolite of Micafungin (HY-17579), which is metabolized by arylsulfatase and exhibits antifungal activity. Micafungin metabolite M1 can be used for research on deep fungal infections caused by Candida and Aspergillus species.
    Micafungin metabolite M1
  • HY-126200R
    Fenpropidin (Standard)
    		Inhibitor
    Fenpropidin (Standard) is the analytical standard of Fenpropidin (HY-126200). This product is intended for research and analytical applications. Fenpropidin, a piperidine, is a fungicide used to control a range of diseases in cereals. Fenpropidin shows antifungal activity against different human pathogenic yeasts and filamentous fungi.
    Fenpropidin (Standard)
  • HY-B1345R
    Piroctone olamine (Standard)
    		Inhibitor
    Piroctone olamine (Standard) is the analytical standard of Piroctone olamine. This product is intended for research and analytical applications. Piroctone olamine is a pyridine derivate. It is known to have a fungicidal effect.
    Piroctone olamine (Standard)
  • HY-163635
    Antifungal agent 102
    		Inhibitor
    Antifungal agent 102 (compound C20) is a antifungal agent aganist B. cinerea with the EC50 of 1.23 μg/mL.
    Antifungal agent 102
  • HY-B2026R
    Propamocarb (Standard)
    		Inhibitor
    Propamocarb (Standard) is the analytical standard of Propamocarb. This product is intended for research and analytical applications. Propamocarb is a systemic fungicide. Propamocarb is widely used to protect cucumbers, tomatoes and other plants from pathogens.
    Propamocarb (Standard)
  • HY-136926
    Candicidin A3
    		Inhibitor
    Candicidin A3 (FR-008I) is an antifungal antibiotic with significant biological activity. Candicidin A3 can effectively inhibit the growth of fungi through its unique three-dimensional structure and seven-membered ring geometry. The absolute configuration of Candicidin A3 is a specific arrangement of multiple chiral centers, which may affect its biological activity and interaction with targets. Candicidin A3 can be used as a potential drug to inhibit fungal infections.
    Candicidin A3
Cat. No. Product Name / Synonyms Application Reactivity