2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Endogenous Metabolite
  4. Antibacterial agent 218

Antibacterial agent 218 (compound d28) is an orally active sterol 24-C-Methyltransferase inhibitor with the IC50 of 0.273 μM. Antibacterial agent 218 shows antifungal activity against the C.albicans SC5314 with the IC50 of 0.25 μg/mL.

For research use only. We do not sell to patients.

Antibacterial agent 218

Antibacterial agent 218 Chemical Structure

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Antibacterial agent 218 Related Antibodies

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Description

Antibacterial agent 218 (compound d28) is an orally active sterol 24-C-Methyltransferase inhibitor with the IC50 of 0.273 μM. Antibacterial agent 218 shows antifungal activity against the C.albicans SC5314 with the IC50 of 0.25 μg/mL[1].

Cellular Effect
Cell Line Type Value Description References
BEAS-2B EC50
> 50 μg/mL
Compound: d28
Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by CCK-8 method
Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by CCK-8 method
[PMID: 38764175]
HUVEC EC50
> 50 μg/mL
Compound: d28
Cytotoxicity against human HUVEC cells incubated for 48 hrs by CCK-8 method
Cytotoxicity against human HUVEC cells incubated for 48 hrs by CCK-8 method
[PMID: 38764175]
Molecular Weight

488.60

Formula

C30H24N4OS
SMILES

CN1C(C)=C(C(N1C2=CC=CC=C2)=O)N3/C(SC=C3C4=CC5=C(C=C4)C=CC=C5)=N/C6=CC=CC=C6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antibacterial agent 218 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 218Antibacterial agent218Antibacterial agent-218FungalEndogenous Metabolitemurine skin infection modelC. albicans infectionsbiofilm formationInhibitorinhibitorinhibit

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Antibacterial agent 218
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