Fungal

Related Products

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (2637)
Antibodies (1)
Related Compound Screening Libraries (1)

By Effects:	Inhibitors (2349)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-116034

Arasertaconazole	Inhibitor
Arasertaconazole is a potent 14α-lanosterol demethylase inhibitor. Arasertaconazole has antifungal and antibacterial activity.

HY-N14979

Dermostatin A	Inhibitor
Dermostatin A is a polyene antibiotic with antifungal activity that can be used in the study of fungal infections.

HY-P5591

PAF26	Inhibitor	98.89%
PAF26 is an antimicrobial peptide against phytopathogenic fungi Penicillium digitatum, Penicillium italicum and Botrytis cinerea.

HY-102025R

Antifungal agent 1 (Standard)	Inhibitor
Antifungal agent 1 (Standard) is the analytical standard of Antifungal agent 1 (HY-102025). This product is intended for research and analytical applications. Antifungal agent 1 is a potent antifungal agent.

HY-121109R

Benalaxyl (Standard)	Inhibitor
Benalaxyl (Standard) is the analytical standard of Benalaxyl (HY-121109). This product is intended for research and analytical applications. Benalaxyl is a fungicide. Benalaxyl has good control of blue mould (Peronospora tubacina).

HY-N14486

Neihumicin	Inhibitor
Neihumicin is resistant to beer Saccharomyces yeast ATCC 9763 and Penicillium italium Wehmer, but not to bacteria.

HY-105110

SCH 39304	Inhibitor
SM-8668 is an effective orally active antifungal agent, with median effective doses (ED₅₀) of 0.18, 3.7, and 5.9 mg/kg for systemic candidiasis, aspergillosis, and cryptococcosis in mice, respectively. Pharmacokinetic studies in mice and rats indicate that SM-8668 has a long half-life and a high total exposure. SM-8668 can be used in anti-infective research.

HY-131051

Antimicrobial agent-41	Inhibitor
Antimicrobial agent-41 (Compound 19) is a thiazolidinedione derivative. Antimicrobial agent-41 exhibits excellent antioxidant activity (IC₅₀ = 27.66 μg/mL). Antimicrobial agent-41 also exhibits antidiabetic activity (IC₅₀ = 40.01 μg/mL). Antimicrobial agent-41 has antimicrobial activity again both bacterial and fungi.

HY-W032878

N,N-Bis(3-aminopropyl)dodecylamine	Inhibitor	98.80%
N,N-Bis(3-aminopropyl)dodecylamine is a potent fungicidal agent with remarkable activity against Aspergillus niger. N,N-Bis(3-aminopropyl)dodecylamine induces oxidative stress and regulates the activities of multiple antioxidant and mitochondrial enzymes in a concentration‑ and duration‑dependent manner. N,N-Bis(3-aminopropyl)dodecylamine disrupts fungal organelles, remodels mitochondrial morphology and impairs mitochondria‑related cellular functions. N,N-Bis(3-aminopropyl)dodecylamine can be used for the research of fungicidal mechanisms and oxidative stress in Aspergillus niger.

HY-167879A

NPD6433	Inhibitor
NPD6433 is a triazenyl indole with broad-spectrum activity against all screening fungal strains. NPD6433 targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH-oxidation activity and arresting essential fatty acid biosynthesis.

HY-W715389

Coumoxystrobin	Inhibitor
Coumoxystrobin is a methoxyacrylate strobilurin fungicide with anti-fungal activity. Coumoxystrobin exhibits inhibitory activity against mycelial growth of Magnaporthe oryzae, increases cell membrane permeability, and reduces respiration. Coumoxystrobin shows protective activity against Magnaporthe oryzae in detached barley leaves. Coumoxystrobin reduces ATP activity of Chlorella vulgaris, thereby causing algal death. Coumoxystrobin can be used in studies related to rice blast disease.

HY-130772

Filipin II	Inhibitor
Filipin II is an antibiotic, which exhibits antifungal efficacy. Filipin II interacts with membrane sterols, leads to changes in membrane structure, inhibits Candida utilis and Saccharomyces cerevisiae with the MIC of 0.03 mg/L and 0.2 μg/L.

HY-N14487

Nemotin	Inhibitor
Nemotin has the activity against Gram-positive bacteria, mycobacterium and fungus, and also against Gram-negative bacteria, but the activity is weak.

HY-N15350

Demethylblasticidin S	Inhibitor
Demethylblasticidin S is an antifungal antibiotic that can be synthesized by Streptomyces griseochromogenes.

HY-N14985

Dictyopanine A	Inhibitor
Dictyopanine A is found in the strain of Dictylpanus sp. Hki 0181. The antibacterial spectrum is narrow, and it has moderate antibacterial activity only against some filamentous fungi and Gram-positive bacteria.

HY-N14685

Heptaibin	Inhibitor
Heptaibin is a peptaibol antifungal antibiotic. Heptaibin has the activity against Gram-positive bacteria (MIC is 8 μg/mL) such as Staphylococcus aureus and fungi (MIC is 13-32 μg/mL) such as Aspergillus, Candida albicans and cryptococcus neofordii, and it has moderate anti-Rhabditella pseudoelongata activity (MIC is 50 μg/mL).

HY-N14122

Cladosporide B	Inhibitor
Cladosporide B is found in the strain of Cladosporium sp. IFM 49189. Cladosporide B has slightly stronger anti-Aspergillus fumigatus activity than Cladosporide A.

HY-N15048

Phellinsin	Inhibitor
Phellinsin selectively inhibits the activity of the chitin synthase I and II with IC₅₀s (μg/mL) of 76 and 28, respectively. Phellinsin has the antifungal activity on Colletotrichum lagenarium, Pyricularia oryzae, Aspergillus fumigatus and Trichophyton mentagrophytes and so on (MIC is 12.5-50 μg/mL).

HY-N14172

Epicorazine B	Inhibitor
Epicorazine B has activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE), MICs of 12.5-25 μg/mL. Epicorazine B also has effect on Candida albicans with a MIC of 25 μg/mL.