Histamine Receptor

Histamine Receptor Related Products (512):

By Type:	Pan (3) Selective (1)
By Effects:	Inhibitors (139) Agonists (37) Antagonists (261) Activators (5) Modulators (8) Controls (7) Ligand (1)

Cat. No.	Product Name	Effect	Purity

HY-A0149

Phenindamine	Inhibitor
Phenindamine (Nu 1504) is an antihistamine.

HY-B1090S

Cinnarizine-d₈	Inhibitor	98.24%
Cinnarizine-d₈ is a deuterium labeled Cinnarizine. Cinnarizine is an antihistamine and a calcium channel blocker.

HY-123432

AHR-13268D	Inhibitor
AHR-13268D is an oral active antiallergic and antihistaminic agent, with bioavailable approximately 88%. AHR-13268D is a potent inhibitor of histamine release from rat peritoneal mast cells, with the IC₅₀ of 0.51 nM.

HY-121215

Chloracyzine	Inhibitor
Chloracyzine is an antianginal agent with spasmolytic properties and prevent or relieve spasms of the coronary vessels. Chloracyzine shows a moderate antihistaminic effect.

HY-155616

KSK94	Antagonist
KSK94 is a high-affinity histamine H3 receptor antagonist, with K_is of 7.9, 2958, 75.2 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. KSK94 can be used for research of nociceptive and neuropathic pain.

HY-N3114

Panaxydiol	Antagonist
Panaxydiol exhibits histamine-release inhibition activity. Panaxydiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-19007

Mifentidine	Inhibitor
Mifentidine (DA 4577) is a potent and selective H2 Receptor antagonist. Mifentidine has an anti-secretion effect and can antagonize the acid-promoting activity of histamine with EC₅₀ 3.28 μM.

HY-107554

Methimepip dihydrobromide	Agonist
Methimepip dihydrobromide is a potent and selective histamine H3 receptor agonist with an EC₅₀ of 0.316nM.

HY-136587R

Oxomemazine (Standard)	Antagonist
Oxomemazine (Standard) is the analytical standard of Oxomemazine (HY-136587). This product is intended for research and analytical applications. Oxomemazine is a phenothiazine-based histamine H1-receptor blocker. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (K_i= 84 nM, M1 receptor) and low (K_i= 1.65 μM, M2 receptor) affinity sites. Oxomemazine is an antihistamine and anticholinergic agent used for the study of cough treatment. Oxomemazine is protective against anaphylactic microshock in guinea pigs.

HY-124515

Dihexyverine hydrochloride	Inhibitor
Dihexyverine hydrochloride is a compound belonging to the amino alcohol ester class. Dihexyverine hydrochloride possesses anticholinergic, smooth muscle relaxant, antihistaminic, and antiemetic effects. Dihexyverine hydrochloride can also shorten the duration of labor. Dihexyverine hydrochloride can be used in research related to gastrointestinal spasms, obstetrics, and other fields.

HY-B1895S

Levodropropizine-d₈	Inhibitor
Levodropropizine-d₈ is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.

HY-106993B

Cipralisant (enantiomer)	Antagonist
Cipralisant (GT-2331) enantiomer is the enantiomer of Cipralisant (HY-106993), Cipralisant is an orally active, potent, selective, and high affinity histamine H₃ receptor antagonist (rat K_i=0.47 nM). Cipralisant (enantiomer) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0520AS1

Benztropine-d₃ mesylate
Benztropine-d₃ (mesylate) is the deuterium labeled Benztropine mesylate. Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects.

HY-B0377G

Famotidine (GMP)	Agonist
Famotidine GMP (MK-208 GMP) is Famotidine (HY-B0377) produced in GMP guideline. Famotidine GMP is a competitive histamine H2-receptor antagonist, inhibits gastric secretion, activates the gastric mucosal defensive mechanisms. Famotidine GMP ameliorates peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD) in rats model.

HY-B0352S3

Mirtazapine-d₄ hydrochloride	Antagonist
Mirtazapine-d₄ hydrochloride is deuterated labeled Mirtazapine (HY-B0352). Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT₂, 5-HT₃, histamine H1 receptor and α2-adrenoceptor antagonist with pK_i values of 8.05, 8.1, 9.3 and 6.95, respectively.

HY-B0971R

Pheniramine maleate (Standard)	Inhibitor
Pheniramine (maleate) (Standard) is the analytical standard of Pheniramine (maleate). This product is intended for research and analytical applications. Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects.

HY-N15704

Cassiaside C2	Inhibitor
Cassiaside C2 is a naphthopyrone with a strong antiallergic activity. Cassiaside C2 inhibits the histamine release from rat peritoneal exudate mast cells induced by antigen-antibody reaction.

HY-B1690AR

Methdilazine hydrochloride (Standard)	Antagonist
Thioridazine (Standard) is the analytical standard of Thioridazine. This product is intended for research and analytical applications. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs).

HY-182627

Clofenetamine hydrochloride	Antagonist
Clofenetamine hydrochloride is a histamine antagonist. Clofenetamine hydrochloride can be used for the research of allergic diseases.

HY-148156

Hydroxydione	Inhibitor
Hydroxydione has an effect of general anesthetic. Hydroxydione is a neuroactive steroid it can be used for anaesthesia related research.

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