Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds 관련 제품 (10878):

Cat. No.	상품명	효과	Purity	Chemical Structure

HY-W722016

1-(2,3-Dichloro-4-hydroxyphenyl)butan-1-one-d₇
1-(2,3-Dichloro-4-hydroxyphenyl)butan-1-one-d₇ is the deuterium labeled 1-(2,3-Dichloro-4-hydroxyphenyl)butan-1-one (HY-W716899).

HY-113216S

Asymmetric dimethylarginine-d₇ hydrochloride hydrate
Asymmetric dimethylarginine-d₇ (hydrochloride hydrate) is the deuterium labeled Asymmetric dimethylarginine. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a num

HY-138642S

Vepdegestrant-d₅
Vepdegestrant-d₅ (ARV-471-d₅) is the deuterium labeled Vepdegestrant (HY-138642). Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a DC₅₀ of about 2 nM.

HY-150092S

(2S,3R)-8(9)-EET-d₁₁
(2S,3R)-8(9)-EET-d₁₁ is deuterium-labeled (2S,3R)-8(9)-EET (HY-150092).

HY-W088426S2

Heptylbenzene-d₂₀
Heptylbenzene-d₂₀ is the deuterium labeled Heptylbenzene.

HY-W011474S

Geranylgeraniol-d₅
Geranylgeraniol-d₅ is the deuterium labeled Geranylgeraniol (HY-W011474). Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model.

HY-20128S

Piperazin-2-one-d₆		99.3%
Piperazin-2-one-d₆ is the deuterium labeled Piperazin-2-one (HY-20128). Piperazin-2-one is a piperazine ring derivative containing amide and ester carbonyl groups. As an important intermediate, Piperazin-2-one can be used for the synthesis of various active compounds.

HY-W740163

Methyl ergonovine-d₅ maleate salt
Methyl ergonovine-d₅ maleate salt is the deuterium labeled Methyl ergonovine maleate salt.

HY-W777067

3-Methyl-2-buten-1-yl Thiolacetate-d₆
3-Methyl-2-buten-1-yl Thiolacetate-d₆ is the deuterium labeled 3-Methyl-2-buten-1-yl Thiolacetate(3-Methyl-2-buten-1-thiol precursor) (HY-W777066).

HY-121467AS

Acotiamide-d₆ hydrochloride
Acotiamide-d₆ (hydrochloride) is deuterium labeled Acotiamide (hydrochloride).

HY-W142175S

1-Butynylbenzene-d₅		98.6%
1-Butynylbenzene-d₅ is the deuterium labeled 1-Butynylbenzene. 1-Butynylbenzene-d5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W709448

Oxaprozin-d10
Oxaprozin-d₁₀ (Oxaprozinum-d₁₀; Wy21743-d₁₀) is the deuterium labeled Oxaprozin (HY-B0808). Oxaprozin is an orally active and potent COX inhibitor, with IC₅₀ values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties.

HY-W127656S2

Choline-d₉ bromide
Choline-d₉ (bromide) is the deuterium labeled Choline bromide.

HY-14956S3

Nemonoxacin-¹³C,d₃
Nemonoxacin-¹³C,d₃ (TG-873870-¹³C,d₃) is the deuterium and ¹³C-labeled Nemonoxacin (HY-14956). Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia.

HY-W738271

Veratryl alcohol-¹³C
Veratryl alcohol-¹³C (3,4-Dimethoxybenzyl alcohol-¹³C) is the ¹³C-labeled Veratryl alcohol (HY-107858). Veratryl alcohol (3,4-Dimethoxybenzyl alcohol) is a secondary metabolite of lignin-degrading fungi, commonly used as a substrate for lignin peroxidase (LiP) to measure lignin degradation activity. Veratryl alcohol protects LiP from inactivation by H2O2 and prevents the accumulation of LiP III compounds. Veratryl alcohol also acts as a stabilizer for manganese-dependent peroxidases (MnP). Veratryl alcohol is a quorum-sensing inhibitor (QSI) and exhibits antibacterial efficacy.

HY-W745890

5b-Dihydrocortisol 21-O-(1-ethoxy ethyl) ether-d₆
5b-Dihydrocortisol 21-O-(1-ethoxy ethyl) ether-d₆ is the deuterium labeled 5b-Dihydrocortisol 21-O-(1-ethoxy ethyl) ether.

HY-W704952

rac 2-(tert-Butyldimethylsilyloxy) Ibuprofen-d₆
rac 2-(tert-Butyldimethylsilyloxy) Ibuprofen-d₆ is the deuterium labeled rac 2-(tert-Butyldimethylsilyloxy) Ibuprofen.

HY-N0545S

Taurocholic acid-¹³C₂,¹⁵N sodium
Taurocholic acid-¹³C₂,¹⁵N (sodium) is the ¹³C- and ¹⁵N- labeled Taurocholic acid (sodium).

HY-113455S1

9(S)-HODE-¹³C₁₈
9(S)-HODE-¹³C₁₈ ((+)-α-Dimophecolic acid-¹³C₁₈) is ¹³C labeled 9S-HODE. 9S-HODE (Alpha-dimorphecolic acid) is an octadecadienoic acid and the main active derivative of linoleic acid, which can reduce the viability of HL-60 cells and induce apoptosis. 9S-HODE is rich in lipid peroxidation (LPO) products and is almost an ideal marker for LPO.

HY-W759947

24-Nor ursodeoxycholic acid acyl-b-D-glucuronide-d₅
24-Nor ursodeoxycholic acid-d5 acyl-b-D-glucuronide is the deuterium labeled 24-Nor ursodeoxycholic acid-d5 acyl-b-D-glucuronide (HY-W759947).

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