2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Monocarboxylate Transporter
  5. MCT4 Isoform

MCT4

Monocarboxylate transporter 4 (MCT4), encoded by SLC16A3, is a proton-coupled monocarboxylate transporter that mediates lactate transport and contributes to intracellular pH regulation and metabolic homeostasis[1][2]. As a key component of glycolytic metabolism, MCT4 supports the export of lactate generated during high glycolytic flux, thereby facilitating maintenance of the acidic extracellular microenvironment associated with metabolic adaptation[2][3]. Mechanistically, MCT4 expression is strongly induced by hypoxia through a HIF-1α-dependent transcriptional program, linking lactate transport directly to cellular hypoxic responses and metabolic reprogramming[4][5]. In cancer models, elevated MCT4 expression is associated with enhanced glycolytic phenotypes and increased lactate handling, highlighting its relevance in tumor metabolism and disease progression[3][6]. Compared with related isoforms, MCT4 displays distinct functional specialization as a predominantly lactate-exporting transporter, whereas MCT1 is broadly involved in bidirectional monocarboxylate transport and MCT2 exhibits substantially higher substrate affinity[2]. This isoform-specific role makes MCT4 particularly important in highly glycolytic and hypoxic cellular environments where efficient lactate efflux is required[2][5]. For experimental applications, pharmacological inhibition and genetic knockdown of MCT4 reduce lactate transport activity in cancer cell models, supporting its utility as a target for investigating metabolic adaptation, tumor bioenergetics, and lactate-dependent signaling pathways[7].

MCT4 관련 제품 (7):

Cat. No. 상품명 효과 Purity
  • HY-139665
    VB124
    		Inhibitor 99.86%
    VB124 is an orally active, potent, and selective MCT4 inhibitor. VB124 can specifically inhibit lactate efflux with IC50s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism.
  • HY-N4115
    Syrosingopine
    		Inhibitor 99.52%
    Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine.
  • HY-148517
    AZD0095
    		Inhibitor 99.42%
    AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib (HY-10205).
  • HY-132301
    MSC-4381
    		Inhibitor 98.89%
    MSC-4381 (MCT4-IN-1), a chemical probe, is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MSC-4381 targets to the cytosolic domain of MCT4. MSC-4381 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MSC-4381 has the potential for MCT4 transporter inhibition research. MSC-4381 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • HY-150314
    MCT-IN-1
    		Inhibitor 99.74%
    MCT-IN-1 (Compound 2) is a potent MCT inhibitor, with IC50 values of 9 nM and 14 nM against MCT1 and MCT4, respectively. MCT-IN-1 can be used in research related to solid tumors.
  • HY-182416
    slCeMM1
    		Inhibitor
    slCeMM1 is a selective SLC16A3 (MCT4) inhibitor. slCeMM1 inhibits lactate transport, induces intracellular lactate accumulation, reduces viability of SLC16A3-dependent cells, and inhibits growth of SLC16A3-dependent cells. slCeMM1 can be used for the research of rheumatoid arthritis and cancer.
  • HY-75625
    2-Hydroxy-4-methoxybenzoic acid
    		Inhibitor 99.64%
    2-Hydroxy-4-methoxybenzoic acid is an orally active inhibitor of MCT-1 and MCT-4, as well as a plant biomarker. 2-Hydroxy-4-methoxybenzoic acid can be isolated from roots. 2-Hydroxy-4-methoxybenzoic acid induces Apoptosis and loss of mitochondrial membrane potential. 2-Hydroxy-4-methoxybenzoic acid exhibits anticancer activity against breast cancer. 2-Hydroxy-4-methoxybenzoic acid normalizes lactic acid levels. 2-Hydroxy-4-methoxybenzoic acid neutralizes viper venom and attenuates its lethal, hemorrhagic, coagulant and anticoagulant activities in male albino mice. 2-Hydroxy-4-methoxybenzoic acid possesses antihyperlipidemic, antidiabetic and hepatoprotective activities.