1. Signaling Pathways
  2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. PAR2 Isoform
  5. PAR2 Antagonist

PAR2 Antagonist

PAR2 Antagonists (5):

Cat. No. Product Name Effect Purity
  • HY-112558
    Antagonist 99.60%
    AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC50 of 23 nM.
  • HY-117793
    Antagonist 99.38%
    I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist.
  • HY-123617
    Antagonist 98.87%
    AZ8838 is a potent, competitive, allosteric, orally active non-peptide small molecule antagonist of PAR2 with a pKi of 6.4 for hPAR2.
  • HY-124748A
    ENMD-1068 hydrochloride
    Antagonist 98.56%
    ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis.
  • HY-124061
    GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons.