2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Telomerase

Telomerase

Telomerase

Related Products

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Telomerase is a DNA polymerase that extends the 3' ends of chromosomes by processively synthesizing multiple telomeric repeats. It is a unique ribonucleoprotein (RNP) containing a specialized telomerase reverse transcriptase (TERT) and telomerase RNA (TER) with its own template and other elements required with TERT for activity (catalytic core), as well as species-specific TER-binding proteins important for biogenesis and assembly (core RNP); other proteins bind telomerase transiently or constitutively to allow association of telomerase and other proteins with telomere ends for regulation of DNA synthesis.

Telomerase activity is responsible for the maintenance of chromosome end structures (telomeres) and cancer cell immortality in most human malignancies, making telomerase an attractive therapeutic target. Indeed, a telomerase inhibitor is expected to provide a therapeutic benefit in most cancers while having little side-effects. The adult stem cells that express telomerase in normal tissues divide slowly and have long telomeres, therefore they should be less impacted by telomerase inhibition than the cancer cells which divide rapidly and usually possess short telomeres.

Telomerase Related Products (51):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-162688
    Anticancer agent 239
    Anticancer agent 239 (Compound 5) is a ligand of hTERT promoter G-quadruplex DNA structures (hTERT G4) (Kd = 1.1 μM), and downregulates hTERT expression. Anticancer agent 239 decreases telomerase activity, shortens telomere length, and induces DNA damage, acute cellular senescence, and apoptosis. Anticancer agent 239 causes mitochondrial dysfunction, disrupts iron metabolism and activates ferroptosis in cancer cells. Anticancer agent 239 inhibits tumor growth in MDA-MB-231 xenograft mouse model.
    Anticancer agent 239
  • HY-176718
    VEGFR-2-IN-69
    		Inhibitor
    VEGFR-2-IN-69 (Compound 5A) is a dual inhibitor of VEGFR-2 and Telomerase, which upregulates the expression of caspase 3, caspase 8 and caspase 9, while downregulating CDK-2, CDK-4 and CDK-6. VEGFR-2-IN-69 exhibits an IC50 of 15.46 µM against HCT116 cells.
    VEGFR-2-IN-69
  • HY-175103
    Guanine-2'-deoxy-β-L-ribofuranosyl-5'-O-triphosphate sodium
    		Inhibitor
    Guanine-2'-deoxy-β-L-ribofuranosyl-5'-O-triphosphate (sodium) is an isomer of dGTP and an inhibitor of telomerase with a Ki of 15 μM for human enzyme.
    Guanine-2'-deoxy-β-L-ribofuranosyl-5'-O-triphosphate sodium
  • HY-17423R
    Abacavir (Standard)
    		Inhibitor
    Abacavir (Standard) is the analytical standard of Abacavir. This product is intended for research and analytical applications. Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity.
    Abacavir (Standard)
  • HY-N14945
    Diazaphilonic acid
    		Inhibitor
    Diazaphilonic acid is found in the strain of Talaramuces flavus PF1195. Diazaphilonic acid has no antibacterial activity, but inhibits the ability of DNA amplification and telomerase.
    Diazaphilonic acid
  • HY-171573
    3′-Azido-2′,3′-dideoxy-GTP
    		Inhibitor
    3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective telomerase inhibitor with a Ki value of 1.5 μM. 3′-Azido-2′,3′-dideoxy-GTP can be incorporated into the 3′-terminus of DNA by telomerase. 3′-Azido-2′,3′-dideoxy-GTP inhibits telomerase activity in HeLa cells in vitro.
    3′-Azido-2′,3′-dideoxy-GTP
  • HY-129334
    Macrocalin B
    		Inhibitor
    Macrocalin B is a diterpenoid, which can be isolated from Isodon xerophilus. Macrocalin B inhibits the proliferation of cancer cells K562, HL-60, A549, MKN, CA and HCT with IC50 of 2.81-171 μM. Macrocalin B inhibits the telomerase in K562 with an IC50 in nanomolar level.
    Macrocalin B
  • HY-17423I
    (R,R)-Abacavir
    		Control
    (R,R)-Abacavir is the (R,R)-enantiomer of Abacavir (HY-17423). Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity.
    (R,R)-Abacavir
  • HY-101089R
    RHPS4 (Standard)
    		Inhibitor
    RHPS4 (Standard) is the analytical standard of RHPS4 (HY-101089). This product is intended for research and analytical applications. RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 μM). RHPS4 is a DNA damage inducer.
    RHPS4 (Standard)
  • HY-15595
    360A
    		Inhibitor
    360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.
    360A
  • HY-48625
    L2H2-6OTD intermediate-2
    		Inhibitor 99.72%
    L2H2-6OTD intermediate-2 is an intermediate of telomerase inhibitor, which can be used in the synthesis of ADC.
    L2H2-6OTD intermediate-2