1. Cell Cycle/DNA Damage
  2. G-quadruplex
    Telomerase
  3. 360A

360A 

Cat. No.: HY-15595
Handling Instructions

360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.

For research use only. We do not sell to patients.

360A Chemical Structure

360A Chemical Structure

CAS No. : 794458-56-3

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Description

360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.

IC50 & Target

IC50: 300 nM (Telomerase)[1]
G-quadruplex[1]

In Vitro

360A inhibits telomerase activity and stabilizes G-quadruplex, with an IC50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC50s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively[1]. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions[2].

Molecular Weight

449.50

Formula

C₂₇H₂₃N₅O₂

CAS No.

794458-56-3

SMILES

O=C(C1=CC=CC(C(NC2=C[N+](C)=C3C=CC=CC3=C2)=O)=N1)NC4=C[N+](C)=C5C=CC=CC5=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[1]

The cell proliferation reagent WST-1 assay is performed. In brief, cells are seeded at various densities, depending on cell type (0.25-4 × 103 cells/well in 100 μL complete medium), in 96-well culture plates and treated with various concentrations (0.1-20 μM) of 360A or the corresponding concentrations of DMSO (control wells) for 3 or 7 days at 37°C in an atmosphere containing 5% CO2. For 7-day assays, the medium is changed on day 3. Experiments are performed in triplicate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

360AG-quadruplexTelomeraseInhibitorinhibitorinhibit

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360A
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