Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Related Products (1734):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W010893

Fmoc-2-Nal-OH		99.59%
Fmoc-2-Nal-OH is an alanine derivative.

HY-W007655

Fmoc-D-Lys(Boc)-OH		99.87%
Fmoc-D-Lys (Boc)-OH is an Fmoc- and Boc-protected D-lysine derivative. Fmoc-D-Lys (Boc)-OH ensures the precise incorporation of D-lysine into peptide chains, maintaining the specific conformation and biological activity of peptides. Fmoc-D-Lys (Boc)-OH can be used in research on the synthesis of peptides containing unnatural amino acids.

HY-W008475

Fmoc-Glu-OAll		98.92%
Fmoc-Glu-OAll is a glutamic acid derivative.

HY-W009124

Fmoc-D-Pro-OH		99.93%
Fmoc-D-Pro-OH is a proline derivative.

HY-W007720

Fmoc-Ser-OH		99.43%
Fmoc-Ser-OH is a serine derivative.

HY-W048704

N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-((4-methoxyphenyl)diphenylmethyl)-L-lysine		98.07%
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-((4-methoxyphenyl)diphenylmethyl)-L-lysine is a lysine derivative.

HY-128676

N-ε-propargyloxycarbonyl-L-lysine hydrochloride		99.80%
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) hydrochloride is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals. N-ε-propargyloxycarbonyl-L-lysine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-Y1844

Fmoc-D-Glu(OtBu)-OH		99.96%
Fmoc-D-Glu(OtBu)-OH is a glutamic acid derivative.

HY-W048918

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-trityl-L-homocysteine		99.78%
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-trityl-L-homocysteine is a cysteine derivative.

HY-W010838

Fmoc-D-Bip(4,4’)-OH		99.88%
Fmoc-D-Bip(4,4’)-OH is an alanine derivative.

HY-W010943

Fmoc-Tyr(Me)-OH		99.91%
Fmoc-Tyr(Me)-OH is a tyrosine derivative.

HY-W036333

N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-N2-methyl-L-lysine		99.73%
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-N2-methyl-L-lysine is a lysine derivative.

HY-W105804

Selenocystamine dihydrochloride		99.63%
Selenocystamine dihydrochloride is a selenocysteine derivative that can be used in the synthesis of other active compounds. Selenocystamine dihydrochloride can also induce the aggregation of amphiphilic p-sulfonatocalixarene to form supramolecular nanoparticles.

HY-22297

Fmoc-Ser-OtBu		99.94%
Fmoc-Ser-OtBu is a serine derivative.

HY-W009088

Fmoc-Tle-OH		99.76%
Fmoc-Tle-OH is a leucine derivative.

HY-112716

N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride		99.0%
N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.

HY-W008021

Fmoc-D-Leu-OH		99.99%
Fmoc-D-Leu-OH is a leucine derivative.

HY-113286

4-Guanidinobutanoic acid		98.0%
4-Guanidinobutanoic acid is a common urinary metabolite and arginine metabolite. 4-Guanidinobutanoic acid can be used in the research of fibromyalgia.

HY-W008971

Fmoc-Phe(4-Cl)-OH		99.81%
Fmoc-Phe(4-Cl)-OH is a phenylalanine derivative.

HY-20897A

5-Bromo-L-tryptophan		99.78%
5-Bromo-L-tryptophan is an α-amino acid derivative that can be found in Semenospongia sp.. 5-Bromo-L-tryptophan can be used to synthesize 5-bromoindole (HY-30236).

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