Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives 관련 제품 (1734):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	상품명	효과	Purity	Chemical Structure

HY-W008995

Fmoc-Phe(4-F)-OH		99.88%
Fmoc-Phe(4-F)-OH is a phenylalanine derivative.

HY-W007618

Boc-Lys-OH		99.56%
Boc-Lys-OH is an amino acid derivative. Boc-Lys-OH plays a key role in peptide synthesis and redox activity research.

HY-W007108

Fmoc-Asp(ODMAB)-OH		98.53%
Fmoc-Asp(ODMAB)-OH is an aspartic acid derivative.

HY-W013749

Fmoc-N-Me-Ser(tBu)-OH		99.84%
Fmoc-N-Me-Ser(tBu)-OH is a serine derivative.

HY-W097054

Fmoc-L-cysteic acid		99.57%
Fmoc-L-cysteic acid is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize triarylsulfonium compounds for radiolabeling of peptides.

HY-W039102

N-Fmoc-N,O-dimethyl-L-serine		98.25%
N-Fmoc-N,O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells.

HY-134669

CypK
CypK (N-Cyclopropene-L-Lysine), a cyclopropene derivative of lysine, is efficiently incorporated into antibodies through genetic-code expansion. CypK is a minimal bioorthogonal handle for the creation of stable therapeutic protein conjugates.

HY-W011000

Fmoc-Cha-OH		99.50%
Fmoc-Cha-OH is an alanine derivative.

HY-W008558

Fmoc-N-Me-Leu-OH		99.72%
Fmoc-N-Me-Leu-OH is an N-Fmoc-N-methyl amino acid that can be used in peptide coupling reactions. Fmoc-N-Me-Leu-OH is primarily used as a standard building block in solid-phase peptide synthesis (SPPS) to introduce N-methylleucine residues into peptide chains, thereby enhancing the enzymatic stability, altering conformational flexibility, and modifying the biological activity of the target peptide.

HY-W010895

Fmoc-1-Nal-OH		99.89%
Fmoc-1-Nal-OH is an alanine derivative.

HY-W013143

Fmoc-Cys(Acm)-OH		99.77%
Fmoc-Cys(Acm)-OH is a cysteine derivative.

HY-W008064

Fmoc-Cit-OH		99.71%
Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif.

HY-W019676

Boc-Tyr-OtBu		99.84%
Boc-Tyr-OtBu is a tyrosine derivative.

HY-P1845

PACAP-38 (31-38), human, mouse, rat		98.80%
PACAP-38 (31-38), human, mouse, rat is a fragment containing the C-terminal 31-38 fragment of PACAP (1-38), human, ovine, rat (HY-P0221). PACAP-38 (31-38), human, mouse, rat does not bind to the PACAP receptor.

HY-W048825

Fmoc-Ala-Ala-OH		99.64%
Fmoc-Ala-Ala-OH is a self-assembling fluorenylmethoxycarbonyl dipeptide, a small amphiphilic building block composed of a dipeptide linked to a fluorenylmethoxycarbonyl (Fmoc) group. Under conditions of pH < 4, Fmoc-Ala-Ala-OH spontaneously assembles to form a nanofiber network, constructing a hydrogel scaffold with a water content exceeding 99% (w/w). The fibers have a diameter of approximately 22 nm, matching the size of extracellular matrix (ECM) components. Fmoc-Ala-Ala-OH supports cell adhesion, proliferation, and maintains of cell phenotype. Fmoc-Ala-Ala-OH's function is to mimic the ECM, providing a 3D growth microenvironment for cells, and Fmoc-Ala-Ala-OH is primarily used in tissue engineering and 3D cell culture, particularly suitable for in vitro culture studies of cells such as chondrocytes[1].

HY-101404A

L-Homocysteine thiolactone hydrochloride		99.99%
L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of Homocysteine. Homocysteine thiolactone hydrochloride prevents translational incorporation of homocysteine into proteins. L-Homocysteine thiolactone hydrochloride can induce elevated HHcy (hyperhomocysteinemia) in mice.

HY-W048693

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyldimethylsilyl)-L-serine		98.54%
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyldimethylsilyl)-L-serine is a serine derivative.

HY-W015231

Boc-β-Ala-OH		98.0%
Boc-β-Ala-OH is an alanine derivative.

HY-W008386

Fmoc-Lys(Fmoc)-OH		98.97%
Fmoc-Lys(Fmoc)-OH is a lysine derivative.

HY-P2237

Boc-Leu-Gly-Arg-AMC		98.66%
Boc-Leu-Gly-Arg-AMC is a fluorogenic AMC substrate for the convertases. Boc-Leu-Gly-Arg-AMC can be used in enzymatic assays.

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