2. Signaling Pathways
  3. Immunology/Inflammation
  4. C-type Lectin-like Receptors (CTLRs)

C-type Lectin-like Receptors (CTLRs)

C-type Lectin-like Receptors (CTLRs)

C-type Lectin-like Receptors (CTLRs) are a class of protein receptors that contain a C-type lectin-like domain but do not necessarily rely on calcium ions to recognize ligands. They are usually classified as activating or inhibitory receptors, based on their intracellular signaling motifs. CTLRs are capable of recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), and play important roles in innate and adaptive immunity. After binding to ligands, CLRs act as antigen-uptake receptors, internalize antigens and present them to T cells, and activate multiple signaling pathways such as NF-κB, IFN, and inflammasomes to regulate the functions of immune cells. Abnormal expression or function of CLRs is closely related to cancer, infectious diseases, autoimmune diseases, and others[1][2].

C-type Lectin-like Receptors (CTLRs) Related Products (47):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P990026A
    Ulviprubart (FUT8-KO)
    		Inhibitor
    Ulviprubart (FUT8-KO) is a humanized anti-KLRG1 monoclonal antibody lacking fucosyltransferase 8 (FUT8). Ulviprubart (FUT8-KO) can be used for the research of diseases such as inclusion body myositis (IBM).
    Ulviprubart (FUT8-KO)
  • HY-P991309
    ZM-008
    		Inhibitor
    ZM-008 is an anti-LLT1 monoclonal antibody. ZM-008 blocks the interaction between LLT1 and CD161 on the surface of NK cells and T cells. ZM-008 restores anti-tumor immune activity, shifts the tumor microenvironment to an immune-responsive state, and recovers NK cell-mediated cytotoxicity against tumor cells, thereby reversing immunosuppression in immune-resistant "cold" tumors. ZM-008 is applicable to the research of immune-resistant solid tumors.
    ZM-008
  • HY-P991931
    Anti-CD72 Antibody
    Anti-CD72 Antibody is an antibody against human CD72. Recommend Isotype Controls:?Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CD72 Antibody
  • HY-P991733
    BDC-3042
    		Agonist
    BDC-3042 is a Dectin-2 agonistic antibody. BDC-3042 can be used for the research of cancer .
    BDC-3042
  • HY-P990179
    Anti-Mouse NKG2AB6 Antibody (16A11)
    		Inhibitor
    Anti-Mouse NKG2AB6 Antibody (16A11) is an anti-mouse NKG2AB6 IgG2b monoclonal antibody. Anti-Mouse NKG2AB6 Antibody (16A11) reduces depletion of antigen-specific CD8 T cells. Anti-Mouse NKG2AB6 Antibody (16A11) can be used for research on cancer such as lung cancer and colon cancer.
    Anti-Mouse NKG2AB6 Antibody (16A11)
  • HY-P991610
    S-095029
    		Inhibitor
    S-095029 is a humanized IgG1 monoclonal antibody inhibitor targeting NKG2A. S-095029 significantly attenuates Fc-effector functions, inhibits the interaction with its ligand HLA-E, and increases the antibody-dependent cellular cytotoxicity mediated by other Fc-competent mAbs. S-095029 has a potent antitumor activity with enhancement of killing activity and cytokine secretion (IFNγ, TNF-α and CXCL9) of NK and γδ T-cells in co-culture with cancer cells.
    S-095029
  • HY-N0434R
    Astragaloside III (Standard)
    		Activator
    Astragaloside III (Standard) is the analytical standard of Astragaloside III (HY-N0434). This product is intended for research and analytical applications. Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces TACE phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer.
    Astragaloside III (Standard)