Anti-Mouse NKG2AB6 Antibody (16A11)
Anti-Mouse NKG2AB6 Antibody (16A11) is an anti-mouse NKG2AB6 IgG2b monoclonal antibody. Anti-Mouse NKG2AB6 Antibody (16A11) reduces depletion of antigen-specific CD8 T cells. Anti-Mouse NKG2AB6 Antibody (16A11) can be used for research on cancer such as lung cancer and colon cancer.
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Isotype
Mouse IgG2b kappa
Recommend Isotype Controls
Species Reactivity
Mouse
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:1×105 TC-1 or 2×105 MC-38 cells injected female C57BL/6J mice (6-8 weeks)[1]
-
Dosage:200 μg
-
Administration:Intravenous injection (i.v.), twice a week, for 2 weeks
-
Result:Significantly increased the complete remission rate to 57 %.
Extended survival by 28 days.
Reduced CD8 T cell exhaustion within tumors without increasing functional markers.
Inhibited the number and effector memory differentiation of peripheral antigen-specific CD8 T cells.
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Product Image
Application
Flow cytometry
Chemical Information
-
Molecular Weight 150 kDa
-
SMILES
[Anti-Mouse NKG2AB6 Antibody (16A11)]
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Riva E, et al. Bimodal Effect of NKG2A Blockade on Intratumoral and Systemic CD8 T Cell Response Induced by Cancer Vaccine. Cancers (Basel). 2024 May 27;16(11):2036. [Content Brief]
[2]. Paul S, et al. Intratumoral natural killer cells show reduced effector and cytolytic properties and control the differentiation of effector Th1 cells. Oncoimmunology. 2016 Sep 20;5(12):e1235106. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse NKG2AB6 Antibody (16A11) Related Classifications
HY-P990179 Related Classifications
Powered by Bioz