2. Signaling Pathways
  3. Immunology/Inflammation
  4. C-type Lectin-like Receptors (CTLRs)
  5. C-type Lectin-like Receptors (CTLRs) Agonist

C-type Lectin-like Receptors (CTLRs) Agonist

C-type Lectin-like Receptors (CTLRs) Agonists (7):

Cat. No. Product Name Effect Purity
  • HY-147295
    Odetiglucan
    		Agonist
    Odetiglucan is a novel β-glucan that is a potent immunostimulant and a Dectin-1 (CLEC7A) agonist. Odetiglucan activates innate immune effector cells and triggers a coordinated anti-cancer immune response.
  • HY-134816
    D-Glucan
    		Agonist
    D-Glucan is an orally effective Dectin-1 receptor immune activator with antioxidant properties (reducing TNF-α). D-Glucan activates macrophages and neutrophils to scavenge free radicals, inhibit oxidative stress and inflammatory responses, and improve insulin sensitivity. D-Glucan promotes glycolysis by enhancing the activity of the antioxidant enzyme glutathione, inhibiting gluconeogenesis and activating GK. D-Glucan can be used in the research of liver damage protection (antagonizing Acetaminophen (HY-66005) toxicity), radiation protection (synergistic with vitamin E) and diabetes (improving glucose metabolism).
  • HY-159114
    Whole Glucan Particles
    		Agonist
    Whole Glucan Particles is a Dectin-1a agonist. Whole Glucan Particles activates the innate immune system to improve the function of macrophages, monocytes and other immune cells.
  • HY-W145481A
    D-Galacto-D-mannan
    		Agonist
    D-Galacto-D-mannan (Carob galactomannan) is an orally active Dectin-2 agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates Dectin-2 to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease.
  • HY-N15934A
    (R)-MMG-1
    		Agonist
    (R)-MMG-1 is the R-enantiomer of MMG-1. MMG-1, a monomycoloyl glycerol, is a C-type lectin receptor agonist. MMG-1, a lipid membrane stabilizer, is an immunopotentiator in liposomes. MMG-1 can be used to prepare lipid nanoparticles for drug delivery.
  • HY-163674
    Mincle agonist 1
    		Agonist
    Mincle agonist 1 (compound 1c) is a Mincle agonist. Mincle agonist 1 can promote IL-1β expression in BMDM cells. Mincle agonist 1 can be used in immune and inflammation related research.
  • HY-P991733
    BDC-3042
    		Agonist
    BDC-3042 is a Dectin-2 agonistic antibody. BDC-3042 can be used for the research of cancer .