C-type Lectin-like Receptors (CTLRs) Inhibitor

Vadalentamig is a human-derived bispecific antibody targeting NKG2D/CD314&ERBB1/EGFR/HER1.

IPH4301 is a monoclonal antibody targeting MICA/B, with dual activities of cytotoxicity and immunoregulation. IPH4301 blocks the interaction between MICA/B and NKG2D, inhibits their hydrolysis into soluble sMICA/B, and mediates antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis against tumor cells expressing MICA/MICB. IPH4301 restores the expression and function of NKG2D on primary NK cells and T cells, reverses the immunosuppression induced by M2 macrophages, and enhances NK cell-mediated tumor cell apoptosis. IPH4301 can be used in research related to cancer and triple-negative breast cancer.

Litifilimab (BIIB059) is a humanized IgG1 monoclonal antibody targeting BDCA2. Litifilimab induces internalization of BDCA2 receptors on the membrane of plasmacytoid dendritic cells, inhibits the TLR7/TLR9 signaling pathway, and suppresses the production of type I interferons. Litifilimab can be used in the research of systemic and cutaneous lupus erythematosus.

Anti-Dectin-1 Antibody (2M24) is a humanized IgG1 monoclonal antibody that targets Dectin-1. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

NKG2D-IN-1 (compound 21) is a natural killer group 2D receptor (NKG2D) inhibitor. NKG2D-IN-1 inhibits the protein-protein interaction between NKG2D and its ligands MICA and ULBP6, with IC₅₀ values of 0.3 μM and 0.7 μM. NKG2D-IN-1 can be used in the research of autoimmune diseases.

Anti-Mouse NKG2A/C/E Antibody (20D5) is an anti-mouse NKG2A/C/E IgG2a monoclonal antibody. Anti-Mouse NKG2A/C/E Antibody (20D5) can activate natural killer (NK) and CD8⁺ T cells. Anti-Mouse NKG2A/C/E Antibody (20D5) can exacerbate liver pathological damage by enhancing the activation of iNKT cells. Anti-Mouse NKG2A/C/E Antibody (20D5) can be used for researches on cancer and immunology such as lymphoma.

Anti-Mouse CLEC9A/CD370 Antibody (7H11) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse CLEC9A/CD370. Anti-Mouse CLEC9A/CD370 Antibody (7H11) reacts with mouse CLEC9A (C-type lectin domain family member 9A) and blocks CLEC9A. Anti-Mouse CLEC9A/CD370 Antibody (7H11) can be used for the researches of cancer and immunology, such as B16.F10-OVA tumor.

7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC₅₀ of 4.66 mM. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells.

Anti-CD371/CLEC12A Antibody (H6e7) is a human monoclonal antibody (mAb) targeting CD371/CLEC12A. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

Anti-Mouse CD209b Antibody (22D1) is an anti-mouse CD209b IgG1 antibody inhibitor derived from the host Armenian Hamster. Anti-Mouse CD209b Antibody (22D1) can block SIGN-R1. Anti-Mouse CD209b Antibody (22D1) can be used for the researches of infection, inflammation and immunology, such as toxoplasma infection and pneumonia.

NKG2D-IN-2 (compound 47) is a natural killer group 2D receptor (NKG2D) inhibitor with IC₅₀s of 0.1 µM and 0.2 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively.

Anti-Mouse/Human KLRG-1 Antibody (2F1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse/human KLRG-1. Anti-Mouse/Human KLRG-1 Antibody (2F1) neutralizes KLRG1. Anti-Mouse/Human KLRG-1 Antibody (2F1) reduces T-cell receptor signals and regulatory T-cell accumulation. Anti-Mouse/Human KLRG-1 Antibody (2F1) can be used for the researches of immunology.

Anti-NKG2D/CD314 Antibody (1D11) is a kind of mouse IgG1 κ chimeric antibody, targeting to human NKG2D/CD314. Anti-NKG2D/CD314 Antibody (1D11) can block the binding of NKG2D to its ligands. Anti-NKG2D/CD314 Antibody (1D11) can be used for the research of infection, such as HIV (human immunodeficiency virus).

Anti-Mouse CD370 Antibody (1F6) reacts with the mouse CD370 (also known as CLEC9A or DNGR1). CD370 is a type II membrane protein with a single extracellular C-type lectin domain. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979).

ISIS 329993 (ISIS-CRPRx) is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis

ABC-015 is a human monoclonal antibody (mAb) targeting KLRG1. ABC-015 can be used in multiple myeloma research.

Anti-Mouse NKG2D Antibody (MI6) is an antibody targeting mouse NKG2D. Anti-Mouse NKG2D Antibody (MI6) can be used in arthritis-related research. For the isotype control of Anti-Mouse NKG2D Antibody (MI6), please refer to Rat IgG1 kappa, Isotype Control (HY-P99979).

ISIS 329993 sodium scrambled negative control is the sequence scrambled negative control of ISIS 329993 sodium.

Anti-Mouse Ly49C Antibody (4LO3311) reacts with the mouse Ly49C. Anti-Mouse Ly49C Antibody (4LO3311) recognizes an epitope located in a 32-amino acid segment of the stalk region immediately adjacent to the carbohydrate recognition domain. Recommend Isotype Controls: Mouse IgG3 kappa, Isotype Control (HY-P99985).

CLT030 Antibody is a human monoclonal antibody targeting CLL1/CLEC12A/CD371, with a K_d value of 7.32 nM against human targets. CLT030 Antibody can be used to synthesize the ADC CLT030. It is applicable to research related to acute myeloid leukemia.