C-type Lectin-like Receptors (CTLRs) Inhibitor

C-type Lectin-like Receptors (CTLRs) Inhibitors (28):

Cat. No.	Product Name	Effect	Purity

HY-P9990

Litifilimab	Inhibitor	99.51%
Litifilimab (BIIB059) is a humanized anti-BDCA2 IgG1 monoclonal antibody administered subcutaneously. Litifilimab can inhibit the production of type I interferons, cytokines and chemokines. Litifilimab can be used in the research of diseases such as systemic lupus erythematosus.

HY-P991818

Anti-Mouse CD370 Antibody (1F6)	Inhibitor
Anti-Mouse CD370 Antibody (1F6) reacts with the mouse CD370 (also known as CLEC9A or DNGR1). CD370 is a type II membrane protein with a single extracellular C-type lectin domain. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979).

HY-P992391

IPH4301	Inhibitor
IPH4301 is a monoclonal antibody targeting MICA/B, with dual activities of cytotoxicity and immunoregulation. IPH4301 blocks the interaction between MICA/B and NKG2D, inhibits their hydrolysis into soluble sMICA/B, and mediates antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis against tumor cells expressing MICA/MICB. IPH4301 restores the expression and function of NKG2D on primary NK cells and T cells, reverses the immunosuppression induced by M2 macrophages, and enhances NK cell-mediated tumor cell apoptosis. IPH4301 can be used in research related to cancer and triple-negative breast cancer.

HY-155311

NKG2D-IN-1	Inhibitor	99.84%
NKG2D-IN-1 (compound 21) is a natural killer group 2D receptor (NKG2D) inhibitor. NKG2D-IN-1 inhibits the protein-protein interaction between NKG2D and its ligands MICA and ULBP6, with IC₅₀ values of 0.3 μM and 0.7 μM. NKG2D-IN-1 can be used in the research of autoimmune diseases.

HY-P990258

Anti-Mouse CLEC9A/CD370 Antibody (7H11)	Inhibitor
Anti-Mouse CLEC9A/CD370 Antibody (7H11) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse CLEC9A/CD370. Anti-Mouse CLEC9A/CD370 Antibody (7H11) reacts with mouse CLEC9A (C-type lectin domain family member 9A) and blocks CLEC9A. Anti-Mouse CLEC9A/CD370 Antibody (7H11) can be used for the researches of cancer and immunology, such as B16.F10-OVA tumor.

HY-P990180

Anti-Mouse NKG2A/C/E Antibody (20D5)	Inhibitor
Anti-Mouse NKG2A/C/E Antibody (20D5) is an anti-mouse NKG2A/C/E IgG2a monoclonal antibody. Anti-Mouse NKG2A/C/E Antibody (20D5) can activate natural killer (NK) and CD8⁺ T cells. Anti-Mouse NKG2A/C/E Antibody (20D5) can exacerbate liver pathological damage by enhancing the activation of iNKT cells. Anti-Mouse NKG2A/C/E Antibody (20D5) can be used for researches on cancer and immunology such as lymphoma.

HY-W159303

7-Hydroxy-2,2-dimethyl-4-chromanone	Inhibitor
7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC₅₀ of 4.66 mM. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells.

HY-P991453

Anti-CD371/CLEC12A Antibody (H6e7)	Inhibitor
Anti-CD371/CLEC12A Antibody (H6e7) is a human monoclonal antibody (mAb) targeting CD371/CLEC12A. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99122

Anti-Mouse CD209b Antibody (22D1)	Inhibitor	99.00%
Anti-Mouse CD209b Antibody (22D1) is an anti-mouse CD209b IgG1 antibody inhibitor derived from the host Armenian Hamster. Anti-Mouse CD209b Antibody (22D1) can block SIGN-R1. Anti-Mouse CD209b Antibody (22D1) can be used for the researches of infection, inflammation and immunology, such as toxoplasma infection and pneumonia.

HY-155312

NKG2D-IN-2	Inhibitor
NKG2D-IN-2 (compound 47) is a natural killer group 2D receptor (NKG2D) inhibitor with IC₅₀s of 0.1 µM and 0.2 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively.

HY-P990205

Anti-Mouse/Human KLRG-1 Antibody (2F1)	Inhibitor
Anti-Mouse/Human KLRG-1 Antibody (2F1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse/human KLRG-1. Anti-Mouse/Human KLRG-1 Antibody (2F1) neutralizes KLRG1. Anti-Mouse/Human KLRG-1 Antibody (2F1) reduces T-cell receptor signals and regulatory T-cell accumulation. Anti-Mouse/Human KLRG-1 Antibody (2F1) can be used for the researches of immunology.

HY-P990829

Anti-NKG2D/CD314 Antibody (1D11)	Inhibitor
Anti-NKG2D/CD314 Antibody (1D11) is a kind of mouse IgG1 κ chimeric antibody, targeting to human NKG2D/CD314. Anti-NKG2D/CD314 Antibody (1D11) can block the binding of NKG2D to its ligands. Anti-NKG2D/CD314 Antibody (1D11) can be used for the research of infection, such as HIV (human immunodeficiency virus).

HY-153489

ISIS 329993	Inhibitor
ISIS 329993 (ISIS-CRPRx) is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis

HY-P991295

ABC-015	Inhibitor
ABC-015 is a human monoclonal antibody (mAb) targeting KLRG1. ABC-015 can be used in multiple myeloma research.

HY-P992071

Anti-Mouse NKG2D Antibody (MI6)	Inhibitor
Anti-Mouse NKG2D Antibody (MI6) is an antibody targeting mouse NKG2D. Anti-Mouse NKG2D Antibody (MI6) can be used in arthritis-related research. For the isotype control of Anti-Mouse NKG2D Antibody (MI6), please refer to Rat IgG1 kappa, Isotype Control (HY-P99979).

HY-153489C

ISIS 329993 sodium scrambled negative control	Inhibitor
ISIS 329993 sodium scrambled negative control is the sequence scrambled negative control of ISIS 329993 sodium.

HY-P991813

Anti-Mouse Ly49C Antibody (4LO3311)	Inhibitor
Anti-Mouse Ly49C Antibody (4LO3311) reacts with the mouse Ly49C. Anti-Mouse Ly49C Antibody (4LO3311) recognizes an epitope located in a 32-amino acid segment of the stalk region immediately adjacent to the carbohydrate recognition domain. Recommend Isotype Controls: Mouse IgG3 kappa, Isotype Control (HY-P99985).

HY-P992333

CLT030 Antibody	Inhibitor
CLT030 Antibody is a human monoclonal antibody targeting CLL1/CLEC12A/CD371, with a K_d value of 7.32 nM against human targets. CLT030 Antibody can be used to synthesize the ADC CLT030. It is applicable to research related to acute myeloid leukemia.

HY-P992138

Vadalentamig	Inhibitor
Vadalentamig is a human-derived bispecific antibody targeting NKG2D/CD314&ERBB1/EGFR/HER1.

HY-P992067

Anti-Human/Monkey NKG2D Antibody (16F16)	Inhibitor
Anti-Human/Monkey NKG2D Antibody (16F16) is an antibody targeting human/monkey NKG2D. The isotype control for Anti-Human/Monkey NKG2D Antibody (16F16) can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).

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