Anti-Mouse CD209b Antibody (22D1) 

Anti-Mouse CD209b Antibody (22D1) is an anti-mouse CD209b IgG1 antibody inhibitor derived from the host Armenian Hamster. Anti-Mouse CD209b Antibody (22D1) can block SIGN-R1. Anti-Mouse CD209b Antibody (22D1) can be used for the researches of infection, inflammation and immunology, such as toxoplasma infection and pneumonia^[1][2][3].

Armenian Hamster IgG

Polyclonal Armenian hamster IgG, Isotype Control

Mouse

CD209b

Anti-Mouse CD209b Antibody (22D1) (5 μg, 30 mins) completely abolishes the uptake of the polysaccharide CPS14 of S. pneumoniae in microglia cells^[2].
Anti-Mouse CD209b Antibody (22D1) (60 mins) blocks pullulan nanogel binding to SIGN-R1 in HeLa cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD209b Antibody (22D1) (50 μg, i.p., each day from days 0 to 1 of infection) decreases parasite burden in the liver and blood and alleviates liver damage in toxoplasma infected mice^[1].
Anti-Mouse CD209b Antibody (22D1) (subcutaneously injection, 60 mins prior to the injection of PNG) blocks pullulan nanogel (PNG) engulfed by medullary macrophages in the draining lymph node^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

69165  [NCBI]

Q8CJ91

in vivo SIGN-R1 blockade; Immunohistochemistry (frozen); Western blot; Flow cytometry

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse CD209b Antibody (22D1)]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

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• [1]. Njiri OA, et al. CD209 C-Type Lectins Promote Host Invasion, Dissemination, and Infection of Toxoplasma gondii. Front Immunol. 2020 Apr 23;11:656.  [Content Brief]

  [2]. Park JY, et al. The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumoniae. Neurosci Lett. 2009 Feb 6;450(3):246-51.  [Content Brief]

  [3]. Muraoka D, et al. Low-frequency CD8+T cells induced by SIGN-R1+ macrophage-targeted vaccine confer SARS-CoV-2 clearance in mice. NPJ Vaccines. 2024 Sep 18;9(1):173.  [Content Brief]