2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3818):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W338346
    Salicylate choline
    Salicylate choline is an orally active derivative of Aspirin (acetylsalicylic acid) (HY-14654). Salicylate choline significantly reduces IL-1β, IL-6, TNF-α and IL-10 levels in cells. Salicylate choline enhances the anti-tumor activity of the CRM1 inhibitor Selinexor (KPT-330) (HY-17536) through inducing S-phase cell cycle arrest and impairing DNA damage repair. Salicylate choline combined with Selinexor demonstrates excellent anti-tumor efficacy in mice xenograft model harboring JeKo-1 cells. Salicylate choline can be used for the study of rheumatic diseases, inflammation and cancer.
    Salicylate choline
  • HY-N17743
    Deltoin
    Deltoin is a Coumarine derivative. Deltoin can be isolated from Seseli resinosum. Deltoin shows inhibitory activity on NO. Deltoin causes a significant inhibition against paw oedema. Deltoin shows anti-inflammatory activity.
    Deltoin
  • HY-N17429
    Olean-12-ene-23
    Olean-12-ene-23 is a natural product that can be found in olives.
    Olean-12-ene-23
  • HY-133644
    Tribromoacetonitrile
    Tribromoacetonitrile is a nitrogen-containing disinfection byproduct.
    Tribromoacetonitrile
  • HY-164568
    7β,16α-Dihydroxybufalin
    7β,16α-Dihydroxybufalin is a dihydroxylated derivative of bufalin, which exhibits cytotoxicities against cancer cell lines.
    7β,16α-Dihydroxybufalin
  • HY-N19281
    Puberulin
    Puberulin is a coumarin compound and an orally effective analgesic. Puberulin is present in Choisya ternata var. Sundance. Puberulin exerts analgesic activity against chemical and heat-induced pain agents in mouse models, and this activity does not involve opioid receptors or muscarinic receptors. Puberulin can be used in the research of neuropathic pain.
    Puberulin
  • HY-W009640
    Mofebutazone
    		98.42%
    Mofebutazone, a monophenyl analogue of Phenylbutazone (HY-B0230), is an orally active anti-inflammatory agent. Mofebutazone can be used for research of asthma.
    Mofebutazone
  • HY-N16801
    Genkwanol B
    Genkwanol B is a natural flavonoid.
    Genkwanol B
  • HY-N3412
    Kuwanol C
    Kuwanol C is a natural flavonoid.
    Kuwanol C
  • HY-180143
    VU6052254
    VU6052254, a derivative of VU0467319 (HY-173396), is a selective, potent, orally active and brain-penetrant muscarinic M1 acetylcholine receptor (mAChR1) positive allosteric modulator with an EC50 of 59 nM. VU6052254 has no activity on the M2-5 receptor (EC50 > 30 μM). VU6052254 can improve memory recognition ability and reverse the cognitive impairment induced by Scopolamine (HY-N0296) with minimum effective dose both of 1 mg/kg. VU6052254 can be used for the research of neurological disease, such as Alzheimer's disease.
    VU6052254
  • HY-120618
    Triazoledione
    Triazoledione (BMS-180492) is a phenylpiperazine compound and the major metabolite of Nefazodone (HY-119209). Triazoledione is used in the research of depression.
    Triazoledione
  • HY-N17170
    22-Hydroxyhopan-2-one
    22-Hydroxyhopan-2-one (2-Oxodiplopterol) is a natural triterpene.
    22-Hydroxyhopan-2-one
  • HY-N17410
    Umbellatolide A
    Umbellatolide A is an 11-noriridoid found in the aerial parts of Morinda umbellata. Umbellatolide A shows no significant cytotoxic activity against human cancer cells.
    Umbellatolide A
  • HY-N16830
    Sanggenol H
    Sanggenol H is a natural phenolic compound.
    Sanggenol H
  • HY-121985
    Protheobromine
    Protheobromine is a cardiotonic and bronchodilator
    Protheobromine
  • HY-N17204
    Homoesperetin-7-O-rutinoside
    Homoesperetin-7-O-rutinoside is a natural flavonoid.
    Homoesperetin-7-O-rutinoside
  • HY-125548
    Antradion
    Antradion is a Phenylbutazone (HY-B0230) analogue.
    Antradion
  • HY-W742156
    N-(9-Fluorenylmethoxycarbonyl) doxorubicin
    N-(9-Fluorenylmethoxycarbonyl) doxorubicin is a derivative of Doxorubicin (HY-15142A).
    N-(9-Fluorenylmethoxycarbonyl) doxorubicin
  • HY-133933
    Maleylsulfathiazole
    Maleylsulfathiazole is an N4-dibasic acid-substituted sulfonamides.
    Maleylsulfathiazole
  • HY-N16910
    3,6-Dimethoxy-8,8-dimethyl-2-phenyl-4H,8H-pyrano[2,3-f]chromen-4-one
    3,6-Dimethoxy-8,8-dimethyl-2-phenyl-4H,8H-pyrano[2,3-f]chromen-4-one is a natural flavonoid.
    3,6-Dimethoxy-8,8-dimethyl-2-phenyl-4H,8H-pyrano[2,3-f]chromen-4-one