VU6052254
VU6052254, a derivative of VU0467319 (HY-173396), is a selective, potent, orally active and brain-penetrant muscarinic M1 acetylcholine receptor (mAChR1) positive allosteric modulator with an EC50 of 59 nM. VU6052254 has no activity on the M2-5 receptor (EC50 > 30 μM). VU6052254 can improve memory recognition ability and reverse the cognitive impairment induced by Scopolamine (HY-N0296) with minimum effective dose both of 1 mg/kg. VU6052254 can be used for the research of neurological disease, such as Alzheimer's disease.
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- CAS. Nr.: 3035701-02-8
- Formel: C25H22F2N4O2
- Molecular Weight:448.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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mAChR1 59 nM (EC50) |
Chemical Information
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CAS. Nr. 3035701-02-8
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Molecular Weight 448.46
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Formel C25H22F2N4O2
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SMILES
FC1=CC(C2=CC=C(C(C)(O)C)C3=NN(C)C=C32)=CC(F)=C1CN4C(C5=CC=CN=C5C4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
VU6052254 Related Classifications
HY-180143 Related Classifications
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