2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3822):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-178978
    α,δ-NAG
    α,δ-NAG is an orally active glutaminase-resistant less-hydrolyzable L-Glutamine derivative. α,δ-NAG is a G protein-coupled receptor (GPCR) allosteric modulator. α,δ-NAG suppresses neutrophilic airway inflammation by activating the GPCR/ERK/MKP-1 pathway. α,δ-NAG can be used for the researches of inflammation and immunology, such as asthma.
    α,δ-NAG
  • HY-N16947
    Benzyl [5-O-benzoyl-β-D-apiofuranosyl(1→2)]-β-D-glucopyranoside
    Benzyl [5-O-benzoyl-β-D-apiofuranosyl(1→2)]-β-D-glucopyranoside is a natural phenolic compound.
    Benzyl [5-O-benzoyl-β-D-apiofuranosyl(1→2)]-β-D-glucopyranoside
  • HY-N17041
    Zedoalactone E
    Zedoalactone E is a natural sesquiterpene.
    Zedoalactone E
  • HY-N17516
    18-Hydroxy-labda-8(17),13(E)-dien-15-oic acid
    18-Hydroxy-labda-8(17),13(E)-dien-15-oic acid is a natural product that can be found in Forsythia suspensa?(Thunb.) Vahl.
    18-Hydroxy-labda-8(17),13(E)-dien-15-oic acid
  • HY-N1374A
    (±)-Magnolin
    (±)-Magnolin is a natural lignan.
    (±)-Magnolin
  • HY-123690
    Etoposide toniribate
    Etoposide toniribate is an active compound.
    Etoposide toniribate
  • HY-175128
    8-(2-Aminoethylthio)guanosine-5'-O-triphosphate sodium
    8-(2-Aminoethylthio)guanosine-5'-O-triphosphate (8-AET-GTP) is a GTP (HY-113225) derivative. GTP is the energy substrate for protein synthesis and gluconeogenesis.
    8-(2-Aminoethylthio)guanosine-5'-O-triphosphate sodium
  • HY-N9718
    Euglobal Ia1
    Euglobal Ia1 is a natural terpenoid.
    Euglobal Ia1
  • HY-119700
    Isocil
    Isocil is an active compound.
    Isocil
  • HY-175981
    Paclitaxel-bromothiophene
    Paclitaxel-bromothiophene is a semisynthetic taxane analogue of Paclitaxel (HY-B0015). Paclitaxel-bromothiophene exhibits potent antiproliferative activity against 4-T1 breast cancer cells, with an IC50 value of 15.18 nM. Paclitaxel-bromothiophene shows high binding affinity to C5aR1 (Kd = 19.4 μM). Paclitaxel-bromothiophene demonstrates excellent anti-tumor efficacy in 4-T1 breast cancer-bearing mice. Paclitaxel-bromothiophene can be used for the study of breast cancer.
    Paclitaxel-bromothiophene
  • HY-N9706
    6′-O-Galloyl desbenzoylpaeoniflorin
    6′-O-Galloyl desbenzoylpaeoniflorin is a natural terpenoid.
    6′-O-Galloyl desbenzoylpaeoniflorin
  • HY-182746
    RG7388-PEG3-Click-F
    RG7388-PEG3-Click-F is a fluorinated analog of the MDM2 inhibitor RG7388 (HY-15676), with an IC50 of 16.8 nM against MDM2. [18F]RG7388-PEG3-Click-F exhibits high uptake and specificity in MDM2-expressing myeloma cells, and can be used for non-invasive assessment of MDM2 protein expression levels in tumors.
    RG7388-PEG3-Click-F
  • HY-N17558
    Schisantherin K
    Schisantherin K is a natural product that can be found in Schisandra chinensis?(Turcz.) Baill..
    Schisantherin K
  • HY-106480
    Butantrone
    Butantrone is a derivative of Dithranol (HY-B0738) with antipsoriatic activity.
    Butantrone
  • HY-204504
    42-O-(2-Aminoethyl)-rapamycin
    42-O-(2-Aminoethyl)-rapamycin (compound 2.3) is a derivative of the mTOR inhibitor rapamycin. 42-O-(2-Aminoethyl)-rapamycin can be used in pharmaceutical research for developing conjugates.
    42-O-(2-Aminoethyl)-rapamycin
  • HY-N17976
    Scrophenoside A
    Scrophenoside A (compound 1) is a phenyl glycoside found in the stems of Picrorhiza scrophulariiflora.Scrophenoside A exhibits anti-asthma activity.Scrophenoside A can be used for the research of asthma.
    Scrophenoside A
  • HY-W700448
    Muraglitazar glucuronide
    Muraglitazar glucuronide is an active compound.
    Muraglitazar glucuronide
  • HY-122511
    Darcanolide
    Darcanolide is an active compound.
    Darcanolide
  • HY-114461A
    (16R,17S)-FD-895
    (16R,17S)-FD-895, a similar compound to FD-895 (HY-114461), is a potent in vivo splice regulatory agent. (16R,17S)-FD-895 retains the similar anti-proliferative activity as FD-895. (16R,17S)-FD-895 can be used for research on colon cancer.
    (16R,17S)-FD-895
  • HY-101608
    Ambasilide
    Ambasilide is an active compound.
    Ambasilide