Paclitaxel-bromothiophene
Paclitaxel-bromothiophene is a semisynthetic taxane analogue of Paclitaxel (HY-B0015). Paclitaxel-bromothiophene exhibits potent antiproliferative activity against 4-T1 breast cancer cells, with an IC50 value of 15.18 nM. Paclitaxel-bromothiophene shows high binding affinity to C5aR1 (Kd = 19.4 μM). Paclitaxel-bromothiophene demonstrates excellent anti-tumor efficacy in 4-T1 breast cancer-bearing mice. Paclitaxel-bromothiophene can be used for the study of breast cancer.
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- Formule: C45H48BrNO14S
- Masse moléculaire:938.83
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
In Vitro
Paclitaxel-bromothiophene (Compound 6v) (48-72 h) exhibits potent antiproliferative activity against 4-T1 breast cancer cells, with an IC50 value of 15.18 nM[1].
Paclitaxel-bromothiophene shows a higher binding affinity to C5aR1 compared to paclitaxel, with a Kd value of 19.4 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4-T1 breast cancer cells were implanted into mice[1]
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Dosage:10, 15, 20 mg/kg
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Administration:i.p., 21 days
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Result:Achieved tumor growth inhibition.
Showed no significant changes in body weight.
Reduced the Ki67 expression.
Chemical Information
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Masse moléculaire 938.83
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Formule C45H48BrNO14S
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SMILES
O=C1[C@H](OC(C)=O)C(C2(C)C)=C(C)[C@@H](OC([C@H](O)[C@@H](NC(C3=CC=CC=C3)=O)C4=CC=C(Br)S4)=O)C[C@@]2(O)[C@@H](OC(C5=CC=CC=C5)=O)C6[C@@]1(C)[C@@H](O)C[C@@]7([H])OC[C@]76OC(C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Paclitaxel-bromothiophene Related Classifications
HY-175981 Related Classifications
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