Paclitaxel-bromothiophene
Paclitaxel-bromothiophene is a semisynthetic taxane analogue of Paclitaxel (HY-B0015). Paclitaxel-bromothiophene exhibits potent antiproliferative activity against 4-T1 breast cancer cells, with an IC50 value of 15.18 nM. Paclitaxel-bromothiophene shows high binding affinity to C5aR1 (Kd = 19.4 μM). Paclitaxel-bromothiophene demonstrates excellent anti-tumor efficacy in 4-T1 breast cancer-bearing mice. Paclitaxel-bromothiophene can be used for the study of breast cancer.
For research use only. We do not sell to patients.
- Formula: C45H48BrNO14S
- Molecular Weight:938.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Paclitaxel-bromothiophene (Compound 6v) (48-72 h) exhibits potent antiproliferative activity against 4-T1 breast cancer cells, with an IC50 value of 15.18 nM[1].
Paclitaxel-bromothiophene shows a higher binding affinity to C5aR1 compared to paclitaxel, with a Kd value of 19.4 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4-T1 breast cancer cells were implanted into mice[1]
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Dosage:10, 15, 20 mg/kg
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Administration:i.p., 21 days
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Result:Achieved tumor growth inhibition.
Showed no significant changes in body weight.
Reduced the Ki67 expression.
Chemical Information
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Molecular Weight 938.83
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Formula C45H48BrNO14S
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SMILES
O=C1[C@H](OC(C)=O)C(C2(C)C)=C(C)[C@@H](OC([C@H](O)[C@@H](NC(C3=CC=CC=C3)=O)C4=CC=C(Br)S4)=O)C[C@@]2(O)[C@@H](OC(C5=CC=CC=C5)=O)C6[C@@]1(C)[C@@H](O)C[C@@]7([H])OC[C@]76OC(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Paclitaxel-bromothiophene Related Classifications
HY-175981 Related Classifications
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