RG7388-PEG3-Click-F
RG7388-PEG3-Click-F is a fluorinated analog of the MDM2 inhibitor RG7388 (HY-15676), with an IC50 of 16.8 nM against MDM2. [18F]RG7388-PEG3-Click-F exhibits high uptake and specificity in MDM2-expressing myeloma cells, and can be used for non-invasive assessment of MDM2 protein expression levels in tumors.
For research use only. We do not sell to patients.
- Formula: C42H48Cl2F3N7O6
- Molecular Weight:874.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
[18F]RG7388-PEG3-Click-F (18.5 kBq; 0.5-2 h) exhibits MDM2-specific uptake in U2OS osteosarcoma cells, and its uptake levels at incubation time points of 0.5 h, 1 h and 2 h are comparable to those in SJSA-1 cells[1].
[18F]RG7388-PEG3-Click-F binds specifically to SJSA-1 osteosarcoma cells, with an equilibrium dissociation constant (KD) of 100.9 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
18F]RG7388-PEG3-click-F (7.03 MBq; i.v.; single dose) shows specific, time-stable uptake in SJSA-1 osteosarcoma xenografts in athymic mice, with measurable tumor-to-muscle contrast at 30 and 60 min post-injection[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 874.78
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Formula C42H48Cl2F3N7O6
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SMILES
COC1=C(C=CC(C(NCCOCCOCCOCC2=CN(N=N2)CCF)=O)=C1)NC([C@@H]3N[C@H]([C@](C4=CC=C(C=C4F)Cl)([C@H]3C5=CC=CC(Cl)=C5F)C#N)CC(C)(C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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