RG7388-PEG3-Click-F 

RG7388-PEG3-Click-F is a fluorinated analog of the MDM2 inhibitor RG7388 (HY-15676), with an IC₅₀ of 16.8 nM against MDM2. [¹⁸F]RG7388-PEG3-Click-F exhibits high uptake and specificity in MDM2-expressing myeloma cells, and can be used for non-invasive assessment of MDM2 protein expression levels in tumors^[1].

[¹⁸F]RG7388-PEG3-Click-F (18.5 kBq; 0.5-2 h) exhibits MDM2-specific uptake in U2OS osteosarcoma cells, and its uptake levels at incubation time points of 0.5 h, 1 h and 2 h are comparable to those in SJSA-1 cells^[1].
[¹⁸F]RG7388-PEG3-Click-F binds specifically to SJSA-1 osteosarcoma cells, with an equilibrium dissociation constant (K_D) of 100.9 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

¹⁸F]RG7388-PEG₃-click-F (1.48 MBq; i.v.; single dose) exhibits hepatobiliary and renal clearance in healthy athymic mice, with minimal normal tissue retention by 3 h post-injection and no significant in vivo defluorination^[1].
¹⁸F]RG7388-PEG₃-click-F (7.03 MBq; i.v.; single dose) shows specific, time-stable uptake in SJSA-1 osteosarcoma xenografts in athymic mice, with measurable tumor-to-muscle contrast at 30 and 60 min post-injection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

874.78

C₄₂H₄₈Cl₂F₃N₇O₆

COC1=C(C=CC(C(NCCOCCOCCOCC2=CN(N=N2)CCF)=O)=C1)NC([C@@H]3N[C@H]([C@](C4=CC=C(C=C4F)Cl)([C@H]3C5=CC=CC(Cl)=C5F)C#N)CC(C)(C)C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Siriki A, et al. Synthesis and evaluation of RG7388-based fluorinated MDM2 inhibitors for developing ¹⁸F-labeled probes for PET imaging. Eur J Med Chem. Published online March 29, 2026.