Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (557)
Related Products (557)
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(E)-DIDS monohydrate sodium
0 ImagesCat. No.: HY-123066ACAS No.: 1263143-51-6(E)-DIDS monohydrate sodium is the E-isomer of DIDS monohydrate sodium (HY-123066). DIDS is a hRAD51 inhibitor with an IC50 value of 90 μM. DIDS exhibits significant inhibitory activity against HIV-1 integrase with an IC50 value of 5 μM.
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Zidapamide
0 ImagesCat. No.: HY-128543CAS No.: 75820-08-5Zidapamide (Compound 4a) is an isomer of indapamide (HY-B0259). Zidapamide has diuretic and natriuretic activities. Zidapamide is used in the study of hypertension.
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KI-MS2-008b
0 ImagesCat. No.: HY-159756KI-MS2-008b is the enantiomer of KI-MS2-008 (HY-159756B). KI-MS2-008 is a selective Max binder. KI-MS2-008 exhibits anticancer activity against Myc-dependent cancers.
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trans-Psoralenoside
0 ImagesCat. No.: HY-N18387trans-Psoralenoside is the trans isomer of Psoralenoside (HY-N7503). trans-Psoralenoside is present in the aerial parts of Ficus palmata. trans-Psoralenoside can be used in studies of liver diseases, kidney diseases and peptic ulcers.
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(S)-NH2-NODAGA hydrochloride
0 ImagesCat. No.: HY-164575CPurity: 99.91%(S)-NH2-NODAGA hydrochloride is the S isomer of NH2-NODAGA hydrochloride (HY-164575B). NH2-NODAGA hydrochloride is an amino-modified NODAGA-type bifunctional chelator, specifically designed for amidation coupling with targeting ligands via squaric acid (SA), followed by coordination with radionuclides (e.g., 68Ga, 177Lu). NH2-NODAGA hydrochloride can be coupled with diethyl squarate to form a PSMA inhibitor conjugate, which is used in prostate cancer research.
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(S)-BI 2536
0 ImagesCat. No.: HY-50698ACAS No.: 1241725-90-5(S)-BI 2536 is the enantiomer of BI 2536 (HY-50698). (S)-BI 2536 acts as an inhibitor of the BRD4 bromodomain and PLK1 kinase, with a Ki value of 54 nM against BRD4 and a Ki value of 0.42 nM against PLK1 kinase. (S)-BI 2536 exhibits anticancer activity against acute myeloid leukemia. (S)-BI 2536 can be used for the research of acute myeloid leukemia.
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trans-Flupentixol
0 ImagesCat. No.: HY-15856DCAS No.: 53772-85-3Synonyms: trans-Flupenthixoltrans-Flupentixol (trans-Flupenthixol) is an isomer of the orally active cis-flupenthixol (HY-184837) and Flupenthixol (HY-15856A) that modulates NMDA receptor subunits. trans-Flupentixol regulates the mRNA expression levels of NMDAR1 and NMDAR2A-D. trans-Flupentixol is used in schizophrenia-related research.
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(±)-Methotrexate-13C,d3 disodium
0 ImagesCat. No.: HY-121151S2Synonyms: (±)-Amethopterin-13C,d3 disodium; (±)-CL14377-13C,d3 disodium; (±)-WR19039-13C,d3 disodium(±)-Methotrexate-13C,d3 disodium ((±)-Amethopterin-13C,d3 disodium; (±)-CL14377-13C,d3 disodium; (±)-WR19039-13C,d3 disodium) is the deuterated, 13C-labeled (±)-Methotrexate (HY-121151). (±)-Methotrexate is the racemate of Methotrexate (HY-14519). Methotrexate is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer.
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(E)-SI-2
0 ImagesCat. No.: HY-121582CAS No.: 380537-35-9Synonyms: (E)-EPH 116(E)-SI-2 is an isomer of SI-2, an inhibitor of the steroid receptor coactivator SRC-3. SI-2 has anticancer activity and increases the number of cytotoxic immune cells in mice with breast cancer.
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Brigimadlin enantiomer
0 ImagesSynonyms: BI 907828 enantiomerBrigimadlin (BI 907828) enantiomer is the Brigimadlin (HY-152859) enantiomer. Brigimadlin is an MDM2 inhibitor with anti-cancer activity.
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(S)-Viloxazine hydrochloride
0 ImagesSynonyms: (S)-Viloxazin hydrochloride; (S)-Emovit hydrochloride(S)-Viloxazine hydrochloride is the isomer of Viloxazine hydrochloride (HY-125784). Viloxazine hydrochloride is the hydrochloride salt form of Viloxazine (HY-W380450). Viloxazine (Viloxazin) hydrochloride is a norepinephrine reuptake inhibitor and a potent 5-HT2C agonist agent and 5-HT2B antagonist，EC50 for 5-HT2C b> is 32 μM，and the IC50 for 5-HT2B is 27 μM. Viloxazine hydrochloride's mechanism of action primarily involves serotonergic and noradrenergic pathways. Viloxazine hydrochloride is used in antidepressant research.
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(rac)-K20
0 ImagesCat. No.: HY-115907ACAS No.: 2915618-92-5(rac)-K20 is the racemate of K20, a KRas G12C inhibitor with an IC50 of 1.16 μM. K20 has antitumor activity.
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(R)-PVTX-405
0 ImagesCat. No.: HY-172930BCAS No.: 2991023-13-1(R)-PVTX-405 is a IKZF2 molecular glue degrader with a DC50 of 4.1 nM. (R)-PVTX-405 is the (R)-enantiomer of PVTX-405 (HY-172930). PVTX-405 is an orally active IKZF2 molecular glue degrader that significantly inhibits MC38 tumor growth in mouse tumor xenograft models. (R)-PVTX-405 can be used in cancer-related research.
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(±)-LY-426965 dihydrochloride
0 ImagesCat. No.: HY-117799CCAS No.: 228418-81-3
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(R)-5-OH-DPAT
0 ImagesCat. No.: HY-131531BCAS No.: 69367-51-7Synonyms: (R)-5-Hydroxy-DPAT(R)-5-OH-DPAT ((R)-5-Hydroxy-DPAT) is the R-enantiomer of 5-OH-DPAT (HY-131531A). 5-OH-DPAT is a weak antagonist of the dopamine D2 receptor (dopamine D2-receptor). 5-OH-DPAT moderately promotes sexual behavior in male rats.
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ent-Rhizocarpic acid
0 ImagesCat. No.: HY-177540CAS No.: 3061155-24-3ent-Rhizocarpic acid is an enantiomer of Rhizocarpic acid. ent-Rhizocarpic acid has more potent antibacterial and antiparasitic activity against Staphylococcus aureus (ATCC 25923) and Giardiaduodenalis 713 compared to Rhizocarpic acid. ent-Rhizocarpic acid also has a weak but selective antitumor activity against NS-1 cells.
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D-Lysine-d4 monohydrochloride
0 ImagesCat. No.: HY-Y1804SCAS No.: 2714413-18-8D-Lysine-d4 monohydrochloride is the d4 D-Lysine monohydrochloride (HY-Y1804). D-Lysine monohydrochloride is the D-enantiomer of L-Lysine (HY-N0469). D-Lysine monohydrochloride is metabolically inert and not utilized for protein synthesis by mammalian ribosomes. D-Lysine monohydrochloride blocks renal uptake of 111In/90Y-Octreotide (HY-P0036)-based probes without inhibiting uptake by tumor/receptor tissues, and thus acts as a renoprotective agent in diagnostic imaging and peptide receptor radionuclide therapy (PRRT). D-Lysine monohydrochloride specifically inhibits the early steps of non-enzymatic glycation by competing with glucose via its free amino group, theoretically, it can serve as a glycation competitor that "does not interfere with protein synthesis" under chronic hyperglycemia in diabetes. D-Lysine monohydrochloride can be used in research related to cancer and diabetes.
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(E/Z)-Sulfosuccinimidyl oleate sodium
0 ImagesCat. No.: HY-112847BCAS No.: 1212012-37-7Synonyms: (E/Z)-Sulfo-N-succinimidyl oleate sodium(E/Z)-Sulfosuccinimidyl oleate sodium is the racemate of (E)-Sulfosuccinimidyl oleate sodium and (Z)-Sulfosuccinimidyl oleate sodium. Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long-chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of the mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to the CD36 receptor on the surface of microglial cells. Sulfosuccinimidyl oleate sodium exhibits anti-inflammatory effects.
