Drug Isomer Control

Drug Isomer Controls (29):

Cat. No.	Product Name	Effect	Purity

HY-N0521

(-)-Gallocatechin	Control	99.98%
(-)-Gallocatechin, an epimer of (-)-Epigallocatechin (EGC) (HY-N0225), is contained in various tea products. (-)-Gallocatechin demonstrates antioxidant activity in vitro, including inhibition of LDL oxidation and DPPH radical scavenging.

HY-100218C

(1R,3R)-RSL3	Control	99.05%
(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.

HY-N7199

(Rac)-Hydnocarpin	Control
(Rac)-Hydnocarpin is a flavonoid isolated from Hydnocarpus anthelminthica, and exhibits moderate cytotoxic on cancer cells.

HY-110258B

(R,S,R)-ML334	Control	98.57%
(R,S,R)-ML334 is the isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K_d of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity.

HY-145388B

AU-16235	Control	99.54%
AU-16235 is an inactive epimer of AU-15330. AU-16235 has no effect on cancer cell survival and growth

HY-107842

(Z)-JIB-04	Control
(Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis.

HY-124883

R-(–)-Flecainide	Control	99.90%
R-(–)-Flecainide is an orally active antiarrhythmic agent, which inhibits ventricular ectopic activity.

HY-139534A

(S)-ARI-1	Control	99.80%
(S)-ARI-1 is an S-enantiomer of ARI-1. ARI-1 is a ROR1 inhibitor and apoptosis inducer, used in NSCLC research.

HY-100540C

Golgicide A-1	Control	99.94%
Golgicide A-1 (GCA-1) is a less active cis-diastereomer of Golgicide A (GCA). Golgicide A-1 weakly inhibits mosquito reproduction.

HY-76542B

(R)-Vitamin D2	Control	98.67%
(R)-Vitamin D2 is the isomer of Vitamin D2 (HY-76542), and can be used as an experimental control. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D.

HY-100218CR

(1R,3R)-RSL3 (Standard)	Control
(1R,3R)-RSL3 (Standard) is the analytical standard of (1R,3R)-RSL3 (HY-100218C). This product is intended for research and analytical applications. (1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.

HY-145572B

(S)-Imlunestrant tosylate	Control	98.74%
(S)-Imlunestrant ((S)-LY-3484356) tosylate is an (S)-enantiomer of Imlunestrant (HY-145572). (S)-Imlunestrant tosylate can be used in research of cancer.

HY-126069

15(R)-Iloprost	Control
15(R)-Iloprost is the unnatural or inverted C-15 epimer of lloprost (HY-A0096).

HY-166480S

(22R)-Budesonide-d₈	Control
(22R)-Budesonide-d₈ ((22R)-BUD-d₈) is the deuterium labeled (22R)-Budesonide. (22R)-Budesonide ((22R)-BUD) is the (22R)-enantiomer of Budesonide (HY-13580). (22R)-Budesonide is a non-halogenated glucocorticoid with high local anti-inflammatory activity.

HY-76542BR

(R)-Vitamin D2 (Standard)	Control
Desmethylmirtazapine (Standard) is the analytical standard of Desmethylmirtazapine. This product is intended for research and analytical applications. Desmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects.

HY-N6008A

7β-O-Methylmorroniside	Control
7β-O-Methylmorroniside (7R-O-methylmorroniside) is a R-isomer of 7-O-Methyl morroniside.

HY-15954A

NVP-CGM097 (stereoisomer)	Control
NVP-CGM097 (stereoisomer) is a stereoisomer of NVP-CGM097, with no special bioactivity. NVP-CGM097 is a potent and selective MDM2 inhibitor.

HY-15344A

(S,S)-Ketone monoester	Control
(S,S)-Ketone monoester is a (S,S)-enantiomer of Ketone monoester (HY-15344). Ketone monoester elevates the AcAc and acetone levels, thereby produces sustained ketosis and significantly delays central nervous system oxygen toxicity (CNS-OT) seizures.

HY-113887A

11β-Prostaglandin F1β	Control
11β-Prostaglandin F1β (11β-PGF1β) is a stereoisomer of PGF1α with inverted C-9 and C-11 hydroxyl groups.

HY-139553A

(R)-Zunsemetinib	Control
(R)-Zunsemetinib is the isomer of Zunsemetinib (HY-139553), and can be used as an experimental control. Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases.

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