2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Imlunestrant

Imlunestrant  (Synonyms: LY-3484356)

Cat. No.: HY-145572 Purity: 99.02%
COA Handling Instructions

Imlunestrant (LY-3484356) is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC).

For research use only. We do not sell to patients.

Imlunestrant Chemical Structure

Imlunestrant Chemical Structure

CAS No. : 2408840-26-4

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1 mg USD 450 In-stock
5 mg USD 1150 In-stock
10 mg USD 1900 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Imlunestrant:

Imlunestrant Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Imlunestrant (LY-3484356) is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC)[1][2].

In Vitro

LY3484356 shows favorable pharmacokinetic (PK) properties, including antitumor activity in ESR1 mutants[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Imlunestrant Related Antibodies
Clinical Trial
Molecular Weight

524.51

Appearance

Solid

Formula

C29H24F4N2O3
CAS No.
SMILES

OC1=CC2=NC=C(C3=CC=C(C(F)(F)F)C=C3O[C@]4([H])C5=CC=C(C=C5)OCCN6CC(C6)CF)C4=C2C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (476.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9065 mL 9.5327 mL 19.0654 mL
5 mM 0.3813 mL 1.9065 mL 3.8131 mL
10 mM 0.1907 mL 0.9533 mL 1.9065 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Imlunestrant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Imlunestrant2408840-26-4LY-3484356LY3484356LY 3484356Estrogen Receptor/ERRSERDER+HER2breast cancerInhibitorinhibitorinhibit

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