199596-24-2
199596-24-2
Chemical Structure
(Z)-JIB-04
Synonym(s): NSC693627
- CAS 番号: 199596-24-2
- Formula:C17H13ClN4
- Molecular Weight:308.76
IUPAC Name: (Z)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine
InChIKey: YHHFKWKMXWRVTJ-XLNRJJMWSA-N
SMILES: ClC1=CN=C(N/N=C(C2=CC=CC=C2)\C3=NC=CC=C3)C=C1
Biological Activity: (Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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(Z)-JIB-04 | 98.89% | (Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis. | ||||||||||||||||||||
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(Z)-JIB-04 (Standard) | ≥98% | (Z)-JIB-04 (Standard) is the analytical standard of (Z)-JIB-04 (HY-107842). This product is intended for research and analytical applications. (Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis. | ||||||||||||||||||||
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Dp2mT | Dp2mT is a non-cytotoxic control compound, with an IC50 of >3 μM for HIV-1 transcription inhibition and an IC50 of >10 μM for cytotoxicity. Dp2mT does not bind to intracellular iron pools. Dp2mT does not inhibit CDK9 activity. | |||||||||||||||||||||
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JIB-04 | 98.84% | JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50s of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. | ||||||||||||||||||||
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WZ811 | 99.80% | WZ811 is an orally active, highly potent competitive antagonist of CXCR4. WZ811 efficiently inhibits CXCR4/SDF-1 (or CXCL12)-mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion in cells (EC50=5.2 nM). | ||||||||||||||||||||
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hRIO2 kinase ligand-1 | 99.95% | hRIO2 kinase ligand-1 (compound 9) is a ligand of hRIO2 kinase, with a Kd value of 520 nM. | ||||||||||||||||||||
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HDM-IN-1 | HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model. | |||||||||||||||||||||
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Dp44mT | 98.0% | Dp44mT is an iron chelator with selective anticancer activity. | ||||||||||||||||||||
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Actionpolymorphol D | Actionpolymorphol D is a pyrazine alkaloid with weak anti-tuberculosis activity against Mycobacterium bovis, with a MIC of 100 μg/mL. | |||||||||||||||||||||
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N1,N3-Di(pyridin-2-yl)benzene-1,3-diamine | N1,N3-Di(pyridin-2-yl)benzene-1,3-diamine is a metal-organic framework (MOF). | |||||||||||||||||||||
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Tri(pyridin-2-yl)amine | Tri(pyridin-2-yl)amine (N,N-Dipyridin-2-ylpyridin-2-amine) is a metal-organic framework (MOF). | |||||||||||||||||||||
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G6Pase catalytic enzyme-IN-1 | G6Pase catalytic enzyme-IN-1 is a competitive inhibitor of glucose-6-phosphatase catalytic enzyme. G6Pase catalytic enzyme-IN-1 has an IC50 of 10 μM in pig liver microsomes. G6Pase catalytic enzyme-IN-1 can be used in studies related to type 2 diabetes. | |||||||||||||||||||||
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