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(Z)-JIB-04 (Synonyms: NSC693627)

Cat. No.: HY-107842 Purity: 98.39%
Handling Instructions

(Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis.

For research use only. We do not sell to patients.

(Z)-JIB-04 Chemical Structure

(Z)-JIB-04 Chemical Structure

CAS No. : 199596-24-2

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Based on 1 publication(s) in Google Scholar

Other Forms of (Z)-JIB-04:

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Description

(Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis[1].

In Vitro

JIB-04 inhibits the demethylase activity of Jumonji enzymes in vitro and in cells, without affecting other α-ketoglutarate dependent hydroxylases or histone modifying enzymes [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

308.76

Formula

C₁₇H₁₃ClN₄

CAS No.

199596-24-2

SMILES

ClC1=CN=C(N/N=C(C2=CC=CC=C2)\C3=NC=CC=C3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6 mg/mL (19.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2388 mL 16.1938 mL 32.3876 mL
5 mM 0.6478 mL 3.2388 mL 6.4775 mL
10 mM 0.3239 mL 1.6194 mL 3.2388 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.6 mg/mL (1.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.6 mg/mL (1.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.6 mg/mL (1.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(Z)-JIB-04NSC693627NSC 693627NSC-693627OthersJIB-04ZisomerJumonjifamily histonedemethylasesInhibitorinhibitorinhibit

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Product Name:
(Z)-JIB-04
Cat. No.:
HY-107842
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